Assessment of Structural Intolerance and Durability
General Structure Information 2wfd LARS structure of the human cytosolic leucyl-trna synthetase editing domain 3.25Å AUTH E.SEIRADAKE,W.MAO,V.HERNANDEZ,S.J.BAKER,AUTH 2 J.J.PLATTNER,M.R.K.ALLEY,S.CUSACKTITL CRYSTAL STRUCTURES OF THE HUMAN AND FUNGALTITL 2 CYTOSOLIC LEUCYL-TRNA SYNTHETASE EDITING DOMAINS:TITL 3 A STRUCTURAL BASIS FOR THE RATIONAL DESIGN OFTITL 4 ANTIFUNGAL BENZOXABOROLES.REF J.MOL.BIOL. V. 390 196 2009REFN ISSN 0022-2836PMID 19426743DOI 10.1016/J.JMB.2009.04.073 Variant Set […]
General Structure Information 1t3g IL1RAPL1 crystal structure of the toll/interleukin-1 receptor (tir) domain of human il-1rapl 2.3Å AUTH J.A.KHAN,E.K.BRINT,L.A.J.ONEILL,L.TONGTITL CRYSTAL STRUCTURE OF THE TOLL/INTERLEUKIN-1TITL 2 RECEPTOR DOMAIN OF HUMAN IL-1RAPLREF J.BIOL.CHEM. V. 279 31664 2004REFN ISSN 0021-9258PMID 15123616DOI 10.1074/JBC.M403434200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3msx ARHGAP20 crystal structure of rhoa.gdp.mgf3 in complex with gap domain of arhgap20 1.65Å AUTH D.UTEPBERGENOV,D.R.COOPER,U.DEREWENDA,A.V.SOMLYO,AUTH 2 Z.S.DEREWENDATITL MECHANISM OF MOLECULAR SPECIFICITY OF RHOGAP DOMAINS TOWARDSTITL 2 SMALL GTPASES OF RHOA FAMILY.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3kqg CD207 trimeric structure of langerin 2.3Å AUTH H.FEINBERG,A.S.POWLESLAND,M.E.TAYLOR,W.I.WEISTITL TRIMERIC STRUCTURE OF LANGERIN.REF J.BIOL.CHEM. V. 285 13285 2010REFN ISSN 0021-9258PMID 20181944DOI 10.1074/JBC.M109.086058 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2i2r KCNIP1 crystal structure of the kchip1/kv4.3 t1 complex 3.35Å AUTH M.PIOLETTI,F.FINDEISEN,G.L.HURA,D.L.MINOR JR.TITL THREE-DIMENSIONAL STRUCTURE OF THE KCHIP1-KV4.3 T1 COMPLEXTITL 2 REVEALS A CROSS-SHAPED OCTAMERREF NAT.STRUCT.MOL.BIOL. V. 13 987 2006REFN ISSN 1545-9993PMID 17057713DOI 10.1038/NSMB1164 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3c5c RASL12 crystal structure of human ras-like, family 12 protein in complex with gdp 1.85Å AUTH L.SHEN,Y.TONG,W.TEMPEL,P.LOPPNAU,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,C.BOUNTRA,J.WEIGELT,A.BOCHKAREV,H.PARKTITL CRYSTAL STRUCTURE OF HUMAN RAS-LIKE, FAMILY 12TITL 2 PROTEIN IN COMPLEX WITH GDP.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2c6u CLEC1B crystal structure of human clec-2 (clec1b) 1.6Å AUTH A.A.WATSON,J.BROWN,K.HARLOS,J.A.EBLE,T.S.WALTER,AUTH 2 C.A.OCALLAGHANTITL THE CRYSTAL STRUCTURE AND MUTATIONAL BINDINGTITL 2 ANALYSIS OF THE EXTRACELLULAR DOMAIN OF THETITL 3 PLATELET-ACTIVATING RECEPTOR CLEC-2.REF J.BIOL.CHEM. V. 282 3165 2007REFN ISSN 0021-9258PMID 17132623DOI 10.1074/JBC.M610383200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2ydx MAT2B crystal structure of human s-adenosylmethionine synthetase 2, beta subunit 2.8Å AUTH N.SHAFQAT,J.R.C.MUNIZ,E.S.PILKA,E.PAPAGRIGORIOU,F.VON DELFT,AUTH 2 U.OPPERMANN,W.W.YUETITL INSIGHT INTO S-ADENOSYLMETHIONINE BIOSYNTHESIS FROM THETITL 2 CRYSTAL STRUCTURES OF THE HUMAN METHIONINETITL 3 ADENOSYLTRANSFERASE CATALYTIC AND REGULATORY SUBUNITS.REF BIOCHEM.J. V. 452 27 2013REFN ISSN 0264-6021PMID 23425511DOI 10.1042/BJ20121580 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4irq B4GALT7 crystal structure of catalytic domain of human beta1, 4galactosyltransferase 7 in closed conformation in complex with manganese and udp 2.3Å AUTH Y.TSUTSUI,B.RAMAKRISHNAN,P.K.QASBATITL CRYSTAL STRUCTURES OF BETA-1,4-GALACTOSYLTRANSFERASE 7TITL 2 ENZYME REVEAL CONFORMATIONAL CHANGES AND SUBSTRATE BINDING.REF J.BIOL.CHEM. V. 288 31963 2013REFN ISSN 0021-9258PMID 24052259DOI 10.1074/JBC.M113.509984 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2f57 PAK7 crystal structure of the human p21-activated kinase 5 1.8Å AUTH J.ESWARAN,W.H.LEE,J.E.DEBRECZENI,P.FILIPPAKOPOULOS,AUTH 2 A.TURNBULL,O.FEDOROV,S.W.DEACON,J.R.PETERSON,S.KNAPPTITL CRYSTAL STRUCTURES OF THE P21-ACTIVATED KINASES PAK4, PAK5,TITL 2 AND PAK6 REVEAL CATALYTIC DOMAIN PLASTICITY OF ACTIVE GROUPTITL 3 II PAKS.REF STRUCTURE V. 15 201 2007REFN ISSN 0969-2126PMID 17292838DOI 10.1016/J.STR.2007.01.001 Variant Set Distributions Ripley’s K Analysis Plots […]