Assessment of Structural Intolerance and Durability
General Structure Information 4fnw ALK crystal structure of the apo f1174l anaplastic lymphoma kinase catalytic domain 1.75Å AUTH L.F.EPSTEIN,H.CHEN,R.EMKEY,D.A.WHITTINGTONTITL THE R1275Q NEUROBLASTOMA MUTANT AND CERTAIN ATP-COMPETITIVETITL 2 INHIBITORS STABILIZE ALTERNATIVE ACTIVATION LOOPTITL 3 CONFORMATIONS OF ANAPLASTIC LYMPHOMA KINASE.REF J.BIOL.CHEM. V. 287 37447 2012REFN ISSN 0021-9258PMID 22932897DOI 10.1074/JBC.M112.391425 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 3wh2 CLEC4E human mincle in complex with citrate 1.3Å AUTH A.FURUKAWA,J.KAMISHIKIRYO,D.MORI,K.TOYONAGA,Y.OKABE,A.TOJI,AUTH 2 R.KANDA,Y.MIYAKE,T.OSE,S.YAMASAKI,K.MAENAKATITL STRUCTURAL ANALYSIS FOR GLYCOLIPID RECOGNITION BY THE C-TYPETITL 2 LECTINS MINCLE AND MCLREF PROC.NATL.ACAD.SCI.USA V. 110 17438 2013REFN ISSN 0027-8424PMID 24101491DOI 10.1073/PNAS.1312649110 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1j0w DOK5 crystal structure analysis of the dok-5 ptb domain 2.5Å AUTH N.SHI,Y.DING,B.Q.QIANG,J.G.YUAN,Z.H.RAOTITL CRYSTAL STRUCTURE ANALYSIS OF THE DOK-5 PTB DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ln3 PCTP structure of human phosphatidylcholine transfer protein in complex with palmitoyl-linoleoyl phosphatidylcholine (seleno-met protein) 2.9Å AUTH S.L.RODERICK,W.W.CHAN,D.S.AGATE,L.R.OLSEN,AUTH 2 M.W.VETTING,K.R.RAJASHANKAR,D.E.COHENTITL STRUCTURE OF HUMAN PHOSPHATIDYLCHOLINE TRANSFERTITL 2 PROTEIN IN COMPLEX WITH ITS LIGAND.REF NAT.STRUCT.BIOL. V. 9 507 2002REFN ISSN 1072-8368PMID 12055623 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4i2x SIRPG crystal structure of signal regulatory protein gamma (sirp-gamma) in complex with fabox117 2.48Å AUTH J.E.NETTLESHIP,J.REN,D.J.SCOTT,N.RAHMAN,D.HATHERLEY,Y.ZHAO,AUTH 2 D.I.STUART,A.N.BARCLAY,R.J.OWENSTITL CRYSTAL STRUCTURE OF SIGNAL REGULATORY PROTEIN GAMMA (SIRPTITL 2 GAMMA) IN COMPLEX WITH AN ANTIBODY FAB FRAGMENT.REF BMC STRUCT.BIOL. V. 13 13 2013REFN ESSN 1472-6807PMID 23826770DOI 10.1186/1472-6807-13-13 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2k40 HESX1 nmr structure of hesx-1 homeodomain double mutant r31l/e42l -1.0Å AUTH J.ASENSIO,M.TORRADO,C.GONZALEZ,A.BASTIDA,F.CORZANATITL THE ROLE OF CONSERVED SALT-BRIDGES ON HOMEODOMAINTITL 2 STABILITYREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2pkd CD84 crystal structure of cd84: insite into slam family function 2.04Å AUTH Q.YAN,V.N.MALASHKEVICH,A.FEDOROV,E.FEDOROV,E.CAO,AUTH 2 J.W.LARY,J.L.COLE,S.G.NATHENSON,S.C.ALMOTITL STRUCTURE OF CD84 PROVIDES INSIGHT INTO SLAMTITL 2 FAMILY FUNCTION.REF PROC.NATL.ACAD.SCI.USA V. 104 10583 2007REFN ISSN 0027-8424PMID 17563375DOI 10.1073/PNAS.0703893104 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2q87 CD300A the crystal structure of the human irp60 ectodomain 1.7Å AUTH N.DIMASI,J.A.MARQUEZTITL THE CRYSTAL STRUCTURE OF IRP60 ECTODOMAINREF TO BE PUBLISHED 2007REFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4lnz MYO5B crystal structure of human myosin 5b globular domain 3.11Å AUTH H.VELVARSKA,D.NIESSINGTITL STRUCTURAL INSIGHTS INTO THE GLOBULAR TAILS OF THE HUMANTITL 2 TYPE V MYOSINS MYO5A, MYO5B, AND MYO5C.REF PLOS ONE V. 8 82065 2013REFN ESSN 1932-6203PMID 24339992DOI 10.1371/JOURNAL.PONE.0082065 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3kjd PARP2 human poly(adp-ribose) polymerase 2, catalytic fragment in complex with an inhibitor abt-888 1.95Å AUTH T.KARLBERG,M.HAMMARSTROM,P.SCHUTZ,L.SVENSSON,H.SCHULERTITL CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PARP2 INTITL 2 COMPLEX WITH PARP INHIBITOR ABT-888.REF BIOCHEMISTRY V. 49 1056 2010REFN ISSN 0006-2960PMID 20092359DOI 10.1021/BI902079Y Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]