General Structure Information
| PDB ID | 3n5n |
| HGNC Gene Label(s) | MUTYH |
| Structure Name | crystal structure analysis of the catalytic domain and interdomain connector of human muty homologue |
| Resolution | 2.3Å |
| Reference | AUTH P.J.LUNCSFORD,D.Y.CHANG,G.SHI,J.BERNSTEIN,A.MADABUSHI,AUTH 2 D.N.PATTERSON,A.L.LU,E.A.TOTHTITL A STRUCTURAL HINGE IN EUKARYOTIC MUTY HOMOLOGUES MEDIATESTITL 2 CATALYTIC ACTIVITY AND RAD9-RAD1-HUS1 CHECKPOINT COMPLEXTITL 3 INTERACTIONS.REF J.MOL.BIOL. V. 403 351 2010REFN ISSN 0022-2836PMID 20816984DOI 10.1016/J.JMB.2010.08.045 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 271 |
| Number Of SNVs | 88 |
| Number Of Permutations | 40345 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.344 |
| p-value | 0.172 |
ClinVar
| Number Of Residues | 271 |
| Number Of SNVs | 10 |
| Number Of Permutations | 4023 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.244 |
| p-value | 0.055 |
COSMIC
| Number Of Residues | 271 |
| Number Of SNVs | 10 |
| Number Of Permutations | 14944 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.067 |
| p-value | 0.206 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 88 |
| Number Of ClinVar SNVs | 8 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.237 |
| p-value | 0.022 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 88 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.186 |
| p-value | 0.053 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
