General Structure Information
| PDB ID | 3gv7 |
| HGNC Gene Label(s) | POLI |
| Structure Name | human dna polymerase iota in complex with t template dna and incoming dttp |
| Resolution | 2.2Å |
| Reference | AUTH K.N.KIROUAC,H.LINGTITL STRUCTURAL BASIS OF ERROR-PRONE REPLICATION AND STALLING ATTITL 2 A THYMINE BASE BY HUMAN DNA POLYMERASE IOTAREF EMBO J. V. 28 1644 2009REFN ISSN 0261-4189PMID 19440206DOI 10.1038/EMBOJ.2009.122 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 377 |
| Number Of SNVs | 101 |
| Number Of Permutations | 28892 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.169 |
| p-value | 0.13 |
COSMIC
| Number Of Residues | 377 |
| Number Of SNVs | 4 |
| Number Of Permutations | 660 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.333 |
| p-value | 0.045 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 101 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 10.0 |
| K Statistic | 0.625 |
| p-value | 0.009 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
