Assessment of Structural Intolerance and Durability
General Structure Information 3ml5 CA7 crystal structure of the c183s/c217s mutant of human ca vii in complex with acetazolamide 2.05Å AUTH A.DI FIORE,E.TRUPPO,C.T.SUPURAN,V.ALTERIO,N.DATHAN,AUTH 2 F.BOOTORABI,S.PARKKILA,S.M.MONTI,G.DE SIMONETITL CRYSTAL STRUCTURE OF THE C183S/C217S MUTANT OF HUMAN CA VIITITL 2 IN COMPLEX WITH ACETAZOLAMIDEREF BIOORG.MED.CHEM.LETT. V. 20 5023 2010REFN ISSN 0960-894XPMID 20688517DOI 10.1016/J.BMCL.2010.07.051 Variant Set Distributions Mapped Variants
General Structure Information 3dof ARL2 complex of arl2 and bart, crystal form 2 3.3Å AUTH T.ZHANG,S.LI,Y.ZHANG,C.ZHONG,Z.LAI,J.DINGTITL CRYSTAL STRUCTURE OF THE ARL2-GTP-BART COMPLEXTITL 2 REVEALS A NOVEL RECOGNITION AND BINDING MODE OFTITL 3 SMALL GTPASE WITH EFFECTORREF STRUCTURE V. 17 602 2009REFN ISSN 0969-2126PMID 19368893DOI 10.1016/J.STR.2009.01.014 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1s9i MAP2K2 x-ray structure of the human mitogen-activated protein kinase kinase 2 (mek2)in a complex with ligand and mgatp 3.2Å AUTH J.F.OHREN,H.CHEN,A.PAVLOVSKY,C.WHITEHEAD,E.ZHANG,AUTH 2 P.KUFFA,C.YAN,P.MCCONNELL,C.SPESSARD,C.BANOTAI,AUTH 3 W.T.MUELLER,A.DELANEY,C.OMER,J.SEBOLT-LEOPOLD,AUTH 4 D.T.DUDLEY,I.K.LEUNG,C.FLAMME,J.WARMUS,M.KAUFMAN,AUTH 5 S.BARRETT,H.TECLE,C.A.HASEMANNTITL STRUCTURES OF HUMAN MAP KINASE KINASE 1 (MEK1) ANDTITL 2 MEK2 DESCRIBE NOVEL NONCOMPETITIVE KINASETITL 3 INHIBITION.REF NAT.STRUCT.MOL.BIOL. V. 11 1192 2004REFN […]
General Structure Information 4kzx EIF1 rabbit 40s ribosomal subunit in complex with eif1. 7.81Å AUTH I.B.LOMAKIN,T.A.STEITZTITL THE INITIATION OF MAMMALIAN PROTEIN SYNTHESIS AND MRNATITL 2 SCANNING MECHANISM.REF NATURE V. 500 307 2013REFN ISSN 0028-0836PMID 23873042DOI 10.1038/NATURE12355 Variant Set Distributions Mapped Variants
General Structure Information 3d42 PTPN7 crystal structure of heptp in complex with a monophosphorylated erk2 peptide 2.46Å AUTH D.A.CRITTON,A.TORTAJADA,G.STETSON,W.PETI,R.PAGETITL STRUCTURAL BASIS OF SUBSTRATE RECOGNITION BY HEMATOPOIETICTITL 2 TYROSINE PHOSPHATASE.REF BIOCHEMISTRY V. 47 13336 2008REFN ISSN 0006-2960PMID 19053285DOI 10.1021/BI801724N Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1am9 SREBF1 human srebp-1a bound to ldl receptor promoter 2.3Å AUTH A.PARRAGA,L.BELLSOLELL,A.R.FERRE-DAMARE,S.K.BURLEYTITL CO-CRYSTAL STRUCTURE OF STEROL REGULATORY ELEMENTTITL 2 BINDING PROTEIN 1A AT 2.3 A RESOLUTION.REF STRUCTURE V. 6 661 1998REFN ISSN 0969-2126PMID 9634703DOI 10.1016/S0969-2126(98)00067-7 Variant Set Distributions Mapped Variants
General Structure Information 4din PRKAR1B novel localization and quaternary structure of the pka ri beta holoenzyme 3.7Å AUTH R.ILOUZ,J.BUBIS,J.WU,Y.Y.YIM,M.S.DEAL,A.P.KORNEV,Y.MA,AUTH 2 D.K.BLUMENTHAL,S.S.TAYLORTITL LOCALIZATION AND QUATERNARY STRUCTURE OF THE PKA RI BETATITL 2 HOLOENZYMEREF PROC.NATL.ACAD.SCI.USA V. 109 12443 2012REFN ISSN 0027-8424PMID 22797896DOI 10.1073/PNAS.1209538109 Variant Set Distributions Mapped Variants
General Structure Information 3rjm CASP2 caspase2 in complex with chdi ligand 33c 2.55Å AUTH M.C.MAILLARD,F.A.BROOKFIELD,S.M.COURTNEY,F.M.EUSTACHE,AUTH 2 M.J.GEMKOW,R.K.HANDEL,L.C.JOHNSON,P.D.JOHNSON,M.A.KERRY,AUTH 3 F.KRIEGER,M.MENICONI,I.MUNOZ-SANJUAN,J.J.PALFREY,H.PARK,AUTH 4 S.SCHAERTL,M.G.TAYLOR,D.WEDDELL,C.DOMINGUEZTITL EXPLOITING DIFFERENCES IN CASPASE-2 AND -3 S(2) SUBSITES FORTITL 2 SELECTIVITY: STRUCTURE-BASED DESIGN, SOLID-PHASE SYNTHESISTITL 3 AND IN VITRO ACTIVITY OF NOVEL SUBSTRATE-BASED CASPASE-2TITL 4 INHIBITORS.REF BIOORG.MED.CHEM. V. 19 5833 2011REFN ISSN 0968-0896PMID 21903398DOI […]
General Structure Information 2no3 MAPK8 novel 4-anilinopyrimidines as potent jnk1 inhibitors 3.2Å AUTH M.LIU,S.WANG,J.E.CLAMPIT,R.J.GUM,D.L.HAASCH,AUTH 2 C.M.RONDINONE,J.M.TREVILLYAN,C.ABAD-ZAPATERO,AUTH 3 E.H.FRY,H.L.SHAM,G.LIUTITL DISCOVERY OF A NEW CLASS OF 4-ANILINOPYRIMIDINESTITL 2 AS POTENT C-JUN N-TERMINAL KINASE INHIBITORS:TITL 3 SYNTHESIS AND SAR STUDIES.REF BIOORG.MED.CHEM.LETT. V. 17 668 2007REFN ISSN 0960-894XPMID 17107797DOI 10.1016/J.BMCL.2006.10.093 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bcd PPP1CC x-ray crystal structure of protein phosphatase-1 with the marine toxin motuporin bound 2.1Å AUTH J.T.MAYNES,H.A.LUU,M.M.CHERNEY,R.J.ANDERSEN,D.WILLIAMS,AUTH 2 C.F.HOLMES,M.N.JAMESTITL CRYSTAL STRUCTURES OF PROTEIN PHOSPHATASE-1 BOUND TOTITL 2 MOTUPORIN AND DIHYDROMICROCYSTIN-LA: ELUCIDATION OF THETITL 3 MECHANISM OF ENZYME INHIBITION BY CYANOBACTERIAL TOXINS.REF J.MOL.BIOL. V. 356 111 2006REFN ISSN 0022-2836PMID 16343532DOI 10.1016/J.JMB.2005.11.019 Variant Set […]