General Structure Information
| PDB ID | 3rjm |
| HGNC Gene Label(s) | CASP2 |
| Structure Name | caspase2 in complex with chdi ligand 33c |
| Resolution | 2.55Å |
| Reference | AUTH M.C.MAILLARD,F.A.BROOKFIELD,S.M.COURTNEY,F.M.EUSTACHE,AUTH 2 M.J.GEMKOW,R.K.HANDEL,L.C.JOHNSON,P.D.JOHNSON,M.A.KERRY,AUTH 3 F.KRIEGER,M.MENICONI,I.MUNOZ-SANJUAN,J.J.PALFREY,H.PARK,AUTH 4 S.SCHAERTL,M.G.TAYLOR,D.WEDDELL,C.DOMINGUEZTITL EXPLOITING DIFFERENCES IN CASPASE-2 AND -3 S(2) SUBSITES FORTITL 2 SELECTIVITY: STRUCTURE-BASED DESIGN, SOLID-PHASE SYNTHESISTITL 3 AND IN VITRO ACTIVITY OF NOVEL SUBSTRATE-BASED CASPASE-2TITL 4 INHIBITORS.REF BIOORG.MED.CHEM. V. 19 5833 2011REFN ISSN 0968-0896PMID 21903398DOI 10.1016/J.BMC.2011.08.020 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 97 |
| Number Of SNVs | 26 |
| Number Of Permutations | 7042 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.052 |
| p-value | 0.746 |
COSMIC
| Number Of Residues | 97 |
| Number Of SNVs | 4 |
| Number Of Permutations | 650 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.909 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 26 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | -0.384 |
| p-value | 0.626 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
