Assessment of Structural Intolerance and Durability
General Structure Information 4ekc RGS2 structure of human regulator of g protein signaling 2 (rgs2) in complex with murine galpha-q(r183c) 7.4Å AUTH M.R.NANCE,B.KREUTZ,V.M.TESMER,R.STERNE-MARR,T.KOZASA,AUTH 2 J.J.TESMERTITL STRUCTURAL AND FUNCTIONAL ANALYSIS OF THE REGULATOR OF GTITL 2 PROTEIN SIGNALING 2-G ALPHA Q COMPLEX.REF STRUCTURE V. 21 438 2013REFN ISSN 0969-2126PMID 23434405DOI 10.1016/J.STR.2012.12.016 Variant Set Distributions Mapped Variants
General Structure Information 2z3r IL15 crystal structure of the il-15/il-15ra complex 2.0Å AUTH M.CHIRIFU,C.HAYASHI,T.NAKAMURA,S.TOMA,T.SHUTO,H.KAI,AUTH 2 Y.YAMAGATA,S.J.DAVIS,S.IKEMIZUTITL CRYSTAL STRUCTURE OF THE IL-15-IL-15RALPHA COMPLEX, ATITL 2 CYTOKINE-RECEPTOR UNIT PRESENTED IN TRANSREF NAT.IMMUNOL. V. 8 1001 2007REFN ISSN 1529-2908PMID 17643103DOI 10.1038/NI1492 Variant Set Distributions Mapped Variants
General Structure Information 4iqr HNF4A multi-domain organization of the hnf4alpha nuclear receptor complex on dna 2.9Å AUTH V.CHANDRA,P.HUANG,N.POTLURI,D.WU,Y.KIM,F.RASTINEJADTITL MULTIDOMAIN INTEGRATION IN THE STRUCTURE OF THE HNF-4 ALPHATITL 2 NUCLEAR RECEPTOR COMPLEX.REF NATURE V. 495 394 2013REFN ISSN 0028-0836PMID 23485969DOI 10.1038/NATURE11966 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1s5o CRAT structural and mutational characterization of l-carnitine binding to human carnitine acetyltransferase 1.8Å AUTH L.GOVINDASAMY,T.KUKAR,W.LIAN,B.PEDERSEN,Y.GU,AUTH 2 M.AGBANDJE-MCKENNA,S.JIN,R.MCKENNA,D.WUTITL STRUCTURAL AND MUTATIONAL CHARACTERIZATION OFTITL 2 L-CARNITINE BINDING TO HUMAN CARNITINETITL 3 ACETYLTRANSFERASE.REF J.STRUCT.BIOL. V. 146 416 2004REFN ISSN 1047-8477PMID 15099582DOI 10.1016/J.JSB.2004.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wwy RECQL structure of human recq-like helicase in complex with a dna substrate 2.9Å AUTH A.C.W.PIKE,Y.ZHANG,C.SCHNECKE,A.CHAIKUAD,T.KROJER,AUTH 2 C.D.O.COOPER,F.VON DELFT,C.H.ARROWSMITH,J.WEIGELT,AUTH 3 A.EDWARDS,C.BOUNTRA,O.GILEADITITL RECQ1 HELICASE-DRIVEN DNA UNWINDING, ANNEALING, AND BRANCHTITL 2 MIGRATION: INSIGHTS FROM DNA COMPLEX STRUCTURESREF PROC.NATL.ACAD.SCI.USA V. 112 4286 2015REFN ISSN 0027-8424PMID 25831490DOI 10.1073/PNAS.1417594112 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 4dg4 PRSS3 human mesotrypsin-s39y complexed with bovine pancreatic trypsin inhibitor (bpti) 1.4Å AUTH M.A.SALAMEH,A.S.SOARES,A.ALLOY,E.S.RADISKYTITL PRESENCE VERSUS ABSENCE OF HYDROGEN BOND DONOR TYR-39TITL 2 INFLUENCES INTERACTIONS OF CATIONIC TRYPSIN AND MESOTRYPSINTITL 3 WITH PROTEIN PROTEASE INHIBITORS.REF PROTEIN SCI. V. 21 1103 2012REFN ISSN 0961-8368PMID 22610453DOI 10.1002/PRO.2097 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3dzy PPARG intact ppar gamma – rxr alpha nuclear receptor complex on dna bound with rosiglitazone, 9-cis retinoic acid and ncoa2 peptide 3.1Å AUTH V.CHANDRA,P.HUANG,Y.HAMURO,S.RAGHURAM,Y.WANG,T.P.BURRIS,AUTH 2 F.RASTINEJADTITL STRUCTURE OF THE INTACT PPAR-GAMMA-RXR- NUCLEAR RECEPTORTITL 2 COMPLEX ON DNA.REF NATURE V. 456 350 2008REFN ISSN 0028-0836PMID 19043829DOI 10.1038/NATURE07413 Variant Set Distributions Ripley’s K […]
General Structure Information 3kfd TGFBR1 ternary complex of tgf-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily 3.0Å AUTH S.RADAEV,Z.ZOU,T.HUANG,E.M.LAFER,A.P.HINCK,P.D.SUNTITL TERNARY COMPLEX OF TRANSFORMING GROWTH FACTOR-BETA1 REVEALSTITL 2 ISOFORM-SPECIFIC LIGAND RECOGNITION AND RECEPTORTITL 3 RECRUITMENT IN THE SUPERFAMILY.REF J.BIOL.CHEM. V. 285 14806 2010REFN ISSN 0021-9258PMID 20207738DOI 10.1074/JBC.M109.079921 Variant Set Distributions Mapped Variants
General Structure Information 1ip0 BTC nmr structure of human betacellulin-2 -1.0Å AUTH K.MIURA,H.DOURA,T.AIZAWA,H.TADA,M.SENO,H.YAMADA,AUTH 2 K.KAWANOTITL SOLUTION STRUCTURE OF BETACELLULIN, A NEW MEMBERTITL 2 OF EGF-FAMILY LIGANDS.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 294 1040 2002REFN ISSN 0006-291XPMID 12074582DOI 10.1016/S0006-291X(02)00585-5 Variant Set Distributions Mapped Variants
General Structure Information 2obh CETN2 centrin-xpc peptide 1.8Å AUTH J.B.CHARBONNIER,E.RENAUD,S.MIRON,M.H.LE DU,Y.BLOUQUIT,AUTH 2 P.DUCHAMBON,P.CHRISTOVA,A.SHOSHEVA,T.ROSE,J.F.ANGULO,AUTH 3 C.T.CRAESCUTITL STRUCTURAL, THERMODYNAMIC, AND CELLULAR CHARACTERIZATION OFTITL 2 HUMAN CENTRIN 2 INTERACTION WITH XERODERMA PIGMENTOSUM GROUPTITL 3 C PROTEIN.REF J.MOL.BIOL. V. 373 1032 2007REFN ISSN 0022-2836PMID 17897675DOI 10.1016/J.JMB.2007.08.046 Variant Set Distributions Mapped Variants