General Structure Information
| PDB ID | 4dg4 |
| HGNC Gene Label(s) | PRSS3 |
| Structure Name | human mesotrypsin-s39y complexed with bovine pancreatic trypsin inhibitor (bpti) |
| Resolution | 1.4Å |
| Reference | AUTH M.A.SALAMEH,A.S.SOARES,A.ALLOY,E.S.RADISKYTITL PRESENCE VERSUS ABSENCE OF HYDROGEN BOND DONOR TYR-39TITL 2 INFLUENCES INTERACTIONS OF CATIONIC TRYPSIN AND MESOTRYPSINTITL 3 WITH PROTEIN PROTEASE INHIBITORS.REF PROTEIN SCI. V. 21 1103 2012REFN ISSN 0961-8368PMID 22610453DOI 10.1002/PRO.2097 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 221 |
| Number Of SNVs | 52 |
| Number Of Permutations | 14295 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.026 |
| p-value | 0.754 |
COSMIC
| Number Of Residues | 221 |
| Number Of SNVs | 24 |
| Number Of Permutations | 5462 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.025 |
| p-value | 0.084 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 52 |
| Number Of COSMIC SNVs | 22 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | -0.033 |
| p-value | 0.515 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
