Assessment of Structural Intolerance and Durability
General Structure Information 3whw NUDT1 mth1 in complex with ruthenium-based inhibitor 2.7Å AUTH M.STREIB,K.KRAELING,K.RICHTER,X.XIE,H.STEUBER,E.MEGGERSTITL AN ORGANOMETALLIC INHIBITOR FOR THE HUMAN REPAIR ENZYMETITL 2 7,8-DIHYDRO-8-OXOGUANOSINE TRIPHOSPHATASE.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 305 2014REFN ISSN 1433-7851PMID 24258965DOI 10.1002/ANIE.201307849 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4djh OPRK1 structure of the human kappa opioid receptor in complex with jdtic 2.9Å AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 4mxw LTBR structure of heterotrimeric lymphotoxin lta1b2 bound to lymphotoxin beta receptor ltbr and anti-lta fab 3.6Å AUTH J.SUDHAMSU,J.YIN,E.Y.CHIANG,M.A.STAROVASNIK,J.L.GROGAN,AUTH 2 S.G.HYMOWITZTITL DIMERIZATION OF LT BETA R BY LT ALPHA 1 BETA 2 IS NECESSARYTITL 2 AND SUFFICIENT FOR SIGNAL TRANSDUCTION.REF PROC.NATL.ACAD.SCI.USA V. 110 19896 2013REFN ISSN 0027-8424PMID 24248355DOI 10.1073/PNAS.1310838110 Variant Set Distributions […]
General Structure Information 2lp0 HOXC9 the solution structure of homeodomain-protein complex -1.0Å AUTH B.ZHOU,C.LIU,Z.XU,G.ZHUTITL STRUCTURAL BASIS FOR HOMEODOMAIN RECOGNITION BY THETITL 2 CELL-CYCLE REGULATOR GEMININREF PROC.NATL.ACAD.SCI.USA 2012REFN ESSN 1091-6490PMID 22615398DOI 10.1073/PNAS.1200874109 Variant Set Distributions Mapped Variants
General Structure Information 3e2u CLIP1 crystal structure of the zink-knuckle 2 domain of human clip-170 in complex with cap-gly domain of human dynactin-1 (p150-glued) 2.6Å AUTH A.WEISBRICH,S.HONNAPPA,R.JAUSSI,O.OKHRIMENKO,D.FREY,AUTH 2 I.JELESAROV,A.AKHMANOVA,M.O.STEINMETZTITL STRUCTURE-FUNCTION RELATIONSHIP OF CAP-GLY DOMAINSREF NAT.STRUCT.MOL.BIOL. V. 14 959 2007REFN ISSN 1545-9993PMID 17828277DOI 10.1038/NSMB1291 Variant Set Distributions Mapped Variants
General Structure Information 2jxc EPS15 structure of the eps15-eh2 stonin2 complex -1.0Å AUTH J.RUMPF,B.SIMON,N.JUNG,T.MARITZEN,V.HAUCKE,M.SATTLER,AUTH 2 Y.GROEMPINGTITL STRUCTURE OF THE EPS15-STONIN2 COMPLEX PROVIDES A MOLECULARTITL 2 EXPLANATION FOR EH-DOMAIN LIGAND SPECIFICITY.REF EMBO J. V. 27 558 2008REFN ISSN 0261-4189PMID 18200045DOI 10.1038/SJ.EMBOJ.7601980 Variant Set Distributions Mapped Variants
General Structure Information 3hr4 NOS2 human inos reductase and calmodulin complex 2.5Å AUTH C.XIA,I.MISRA,T.IYANAKI,J.J.K.KIMTITL REGULATION OF INTERDOMAIN INTERACTIONS BY CAM IN INDUCIBLETITL 2 NITRIC OXIDE SYNTHASEREF J.BIOL.CHEM. 2009REFN ESSN 1083-351X Variant Set Distributions Mapped Variants
General Structure Information 4mle GCK human glucokinase in complex with novel amino thiazole activator 2.6Å AUTH R.J.HINKLIN,S.A.BOYD,M.J.CHICARELLI,K.R.CONDROSKI,AUTH 2 W.E.DEWOLF,P.A.LEE,W.LEE,A.SINGH,L.THOMAS,W.C.VOEGTLI,AUTH 3 L.WILLIAMS,T.D.AICHERTITL IDENTIFICATION OF A NEW CLASS OF GLUCOKINASE ACTIVATORSTITL 2 THROUGH STRUCTURE-BASED DESIGN.REF J.MED.CHEM. V. 56 7669 2013REFN ISSN 0022-2623PMID 24015910DOI 10.1021/JM401116K Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 2gl7 CTNNB1 crystal structure of a beta-catenin/bcl9/tcf4 complex 2.6Å AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2jod ADCYAP1R1 pac1-rshort n-terminal ec domain pacap(6-38) complex -1.0Å AUTH C.SUN,D.SONG,R.A.DAVIS-TABER,L.W.BARRETT,V.E.SCOTT,AUTH 2 P.L.RICHARDSON,A.PEREDA-LOPEZ,M.E.UCHIC,AUTH 3 L.R.SOLOMON,M.R.LAKE,K.A.WALTER,P.J.HAJDUK,AUTH 4 E.T.OLEJNICZAKTITL SOLUTION STRUCTURE AND MUTATIONAL ANALYSIS OFTITL 2 PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDETITL 3 BINDING TO THE EXTRACELLULAR DOMAIN OF PAC1-RS.REF PROC.NATL.ACAD.SCI.USA V. 104 7875 2007REFN ISSN 0027-8424PMID 17470806DOI 10.1073/PNAS.0611397104 Variant Set Distributions Mapped Variants