Assessment of Structural Intolerance and Durability
General Structure Information 2o8b MSH2 human mutsalpha (msh2/msh6) bound to adp and a g t mispair 2.75Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v5e GDNF the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. 2.35Å AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 Variant Set […]
General Structure Information 2gwf USP8 structure of a usp8-nrdp1 complex 2.3Å AUTH G.V.AVVAKUMOV,J.R.WALKER,S.XUE,P.J.FINERTY JR.,F.MACKENZIE,AUTH 2 E.M.NEWMAN,S.DHE-PAGANONTITL AMINO-TERMINAL DIMERIZATION, NRDP1-RHODANESE INTERACTION,TITL 2 AND INHIBITED CATALYTIC DOMAIN CONFORMATION OF THETITL 3 UBIQUITIN-SPECIFIC PROTEASE 8 (USP8).REF J.BIOL.CHEM. V. 281 38061 2006REFN ISSN 0021-9258PMID 17035239DOI 10.1074/JBC.M606704200 Variant Set Distributions Mapped Variants
General Structure Information 3tje FAS crystal structure of fas receptor extracellular domain in complex with fab e09 1.93Å AUTH M.CHODORGE,S.ZUGER,C.STIRNIMANN,C.BRIAND,L.JERMUTUS,AUTH 2 M.G.GRUTTER,R.R.MINTERTITL A SERIES OF FAS RECEPTOR AGONIST ANTIBODIES THAT DEMONSTRATETITL 2 AN INVERSE CORRELATION BETWEEN AFFINITY AND POTENCY.REF CELL DEATH DIFFER. V. 19 1187 2012REFN ISSN 1350-9047PMID 22261618DOI 10.1038/CDD.2011.208 Variant Set Distributions Mapped Variants
General Structure Information 2adc PTBP1 solution structure of polypyrimidine tract binding protein rbd34 complexed with cucucu rna -1.0Å AUTH F.C.OBERSTRASS,S.D.AUWETER,M.ERAT,Y.HARGOUS,AUTH 2 A.HENNING,P.WENTER,L.REYMOND,B.AMIR-AHMADY,AUTH 3 S.PITSCH,D.L.BLACK,F.H.T.ALLAINTITL STRUCTURE OF PTB BOUND TO RNA: SPECIFIC BINDINGTITL 2 AND IMPLICATIONS FOR SPLICING REGULATIONREF SCIENCE V. 309 2054 2005REFN ISSN 0036-8075PMID 16179478DOI 10.1126/SCIENCE.1114066 Variant Set Distributions Mapped Variants
General Structure Information 3qwr IL12B crystal structure of il-23 in complex with an adnectin 3.25Å AUTH V.RAMAMURTHY,S.R.KRYSTEK,A.BUSH,A.WEI,S.L.EMANUEL,AUTH 2 R.DAS GUPTA,A.JANJUA,L.CHENG,M.MURDOCK,B.ABRAMCZYK,D.COHEN,AUTH 3 Z.LIN,P.MORIN,J.H.DAVIS,M.DABRITZ,D.C.MCLAUGHLIN,K.A.RUSSO,AUTH 4 G.CHAO,M.C.WRIGHT,V.A.JENNY,L.J.ENGLE,E.FURFINE,S.SHERIFFTITL STRUCTURES OF ADNECTIN/PROTEIN COMPLEXES REVEAL AN EXPANDEDTITL 2 BINDING FOOTPRINT.REF STRUCTURE V. 20 259 2012REFN ISSN 0969-2126PMID 22325775DOI 10.1016/J.STR.2011.11.016 Variant Set Distributions Mapped Variants
General Structure Information 1bnd BDNF structure of the brain-derived neurotrophic factor(slash)neurotrophin 3 heterodimer 2.3Å AUTH R.C.ROBINSON,C.RADZIEJEWSKI,D.I.STUART,E.Y.JONESTITL STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHICTITL 2 FACTOR/NEUROTROPHIN 3 HETERODIMER.REF BIOCHEMISTRY V. 34 4139 1995REFN ISSN 0006-2960PMID 7703225DOI 10.1021/BI00013A001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4nnr FKBP2 fkbp13-fk506 complex 1.98Å AUTH L.W.SCHULTZ,P.K.MARTIN,J.LIANG,S.L.SCHREIBER,J.CLARDYTITL ATOMIC STRUCTURE OF THE IMMUNOPHILIN FKBP13-FK506 COMPLEX:TITL 2 INSIGHTS INTO THE COMPOSITE BINDING SURFACE FOR CALCINEURINREF J.AM.CHEM.SOC. V. 116 3129 1994REFN ISSN 0002-7863DOI 10.1021/JA00086A055 Variant Set Distributions Mapped Variants
General Structure Information 1nt3 NTF3 human neurotrophin-3 2.4Å AUTH M.J.BUTTE,P.K.HWANG,W.C.MOBLEY,R.J.FLETTERICKTITL CRYSTAL STRUCTURE OF NEUROTROPHIN-3 HOMODIMER SHOWS DISTINCTTITL 2 REGIONS ARE USED TO BIND ITS RECEPTORS.REF BIOCHEMISTRY V. 37 16846 1998REFN ISSN 0006-2960PMID 9836577DOI 10.1021/BI981254O Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1iil FGFR2 crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 2.3Å AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]