General Structure Information
| PDB ID | 2v5e |
| HGNC Gene Label(s) | GDNF |
| Structure Name | the structure of the gdnf:coreceptor complex: insights into ret signalling and heparin binding. |
| Resolution | 2.35Å |
| Reference | AUTH V.PARKASH,V.-M.LEPPANEN,H.VIRTANEN,J.-M.JURVANSUU,AUTH 2 M.M.BESPALOV,Y.A.SIDOROVA,P.RUNEBERG-ROOS,M.SAARMA,AUTH 3 A.GOLDMANTITL THE STRUCTURE OF THE GLIAL CELL LINE-DERIVEDTITL 2 NEUROTROPHIC FACTOR-CORECEPTOR COMPLEX: INSIGHTSTITL 3 INTO RET SIGNALING AND HEPARIN BINDING.REF J.BIOL.CHEM. V. 283 35164 2008REFN ISSN 0021-9258PMID 18845535DOI 10.1074/JBC.M802543200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 101 |
| Number Of SNVs | 18 |
| Number Of Permutations | 3517 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.052 |
| p-value | 0.064 |
ClinVar
| Number Of Residues | 101 |
| Number Of SNVs | 3 |
| Number Of Permutations | 183 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 1.0 |
| p-value | 0.13 |
COSMIC
| Number Of Residues | 101 |
| Number Of SNVs | 4 |
| Number Of Permutations | 691 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.333 |
| p-value | 0.928 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of ClinVar SNVs | 3 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.83 |
| p-value | 0.115 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 18 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.281 |
| p-value | 0.934 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
