2O8B.A | MSH2 – ASTRID

2O8B.A | MSH2

General Structure Information

PDB ID	2o8b
HGNC Gene Label(s)	MSH2
Structure Name	human mutsalpha (msh2/msh6) bound to adp and a g t mispair
Resolution	2.75Å
Reference	AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018

Variant Set Distributions

ExAC Variants

Number Of Residues	831
Number Of SNVs	281
Number Of Permutations	76588
Optimal Distance Threshold	40.0
K Statistic	0.469
p-value	0.173

ClinVar

Number Of Residues	831
Number Of SNVs	42
Number Of Permutations	20447
Optimal Distance Threshold	12.0
K Statistic	0.093
p-value	0.0

COSMIC

Number Of Residues	831
Number Of SNVs	9
Number Of Permutations	2949
Optimal Distance Threshold	5.0
K Statistic	0.028
p-value	0.223

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs	281
Number Of ClinVar SNVs	56
Optimal Distance Threshold	13.0
K Statistic	0.03
p-value	0.183

Cosmic vs. ExAC

Number Of ExAC SNVs	281
Number Of COSMIC SNVs	6
Optimal Distance Threshold	20.0
K Statistic	0.212
p-value	0.236

Pathogenic Proximity Analysis

ClinVar PathProx Analysis

COSMIC PathProx Analysis

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:47630334	rs63750466	A>T	A:2	(-54.81, 31.99, 28.14)
2:47630341		Q>L	A:4	(-59.16, 34.51, 24.65)
2:47630346		K>E	A:6	(-57.56, 42.67, 21.38)
2:47630353	rs17217716	T>M	A:8	(-60.50, 39.54, 14.83)
2:47630374		A>G	A:15	(-58.52, 36.90, 0.93)
2:47630380		V>G	A:17	(-60.85, 31.97, -0.60)
2:47630385	rs141711342	F>L	A:19	(-55.01, 31.13, 3.82)
2:47630391		R>G	A:21	(-57.70, 26.10, -2.72)
2:47630397	rs372619120	F>L	A:23	(-53.58, 25.33, 4.84)
2:47630412	rs63751246 MMR_c.82G>T CM056002	E>K	A:28	(-47.64, 16.03, 3.11)
2:47630422		T>I	A:31	(-48.13, 14.78, 12.94)
2:47630425	rs552361923	T>S	A:32	(-44.39, 16.19, 14.53)
2:47630428		T>I	A:33	(-45.26, 19.75, 12.41)
2:47630444		D>E	A:38	(-46.96, 36.85, 10.84)
2:47630446		R>P	A:39	(-52.28, 36.88, 9.49)
2:47630448	rs63751260	G>S	A:40	(-48.65, 40.99, 12.61)
2:47630458	rs17217723	Y>C	A:43	(-48.31, 35.24, 15.45)
2:47630463		A>S	A:45	(-53.72, 28.67, 13.41)
2:47630468	rs33946261	H>Q	A:46	(-54.93, 27.91, 10.21)
2:47630469		G>R	A:47	(-56.33, 23.07, 11.30)
2:47630476	rs63750335	D>V	A:49	(-52.02, 23.10, 13.90)
2:47630477		D>E	A:49	(-52.02, 23.10, 13.90)
2:47630485		L>P	A:52	(-52.84, 21.41, 19.15)
2:47630487		A>S	A:53	(-54.14, 25.39, 20.03)
2:47630490		A>S	A:54	(-57.46, 25.00, 21.17)
2:47630491		A>V	A:54	(-57.46, 25.00, 21.17)
2:47630493	rs63750337 MMR_c.163delC CD032126	R>G	A:55	(-56.44, 20.30, 22.13)
2:47630494		R>Q	A:55	(-56.44, 20.30, 22.13)
2:47630505		K>E	A:59	(-57.33, 24.32, 27.84)
2:47630512		Q>P	A:61	(-63.25, 23.28, 20.38)
2:47630514		G>R	A:62	(-64.54, 28.46, 20.75)
2:47630529		M>V	A:67	(-61.65, 30.34, 6.84)
2:47635545		K>E	A:73	(-66.93, 29.06, 5.92)
2:47635548	rs150548839	N>H	A:74	(-64.80, 23.57, 6.05)
2:47635554	rs63750042 MMR_c.226C>T CM056650	Q>E	A:76	(-60.23, 24.32, 11.36)
2:47635556	COSM1021241	Q>H	A:76	(-60.23, 24.32, 11.36)
2:47635560		V>I	A:78	(-56.94, 29.88, 16.09)
2:47635584		E>Q	A:86	(-44.02, 34.20, 23.18)
2:47635588		S>C	A:87	(-46.62, 30.03, 25.30)
2:47635602		L>V	A:92	(-44.55, 22.93, 20.87)
2:47635615	rs63750002	R>H	A:96	(-46.26, 18.20, 23.18)
2:47635632	rs193922373 CM023955	V>I	A:102	(-43.17, 30.84, 11.09)
2:47635640	rs372972328	K>N	A:104	(-43.48, 36.52, 7.49)
2:47635645	rs41295286	R>K	A:106	(-43.63, 38.39, -0.21)
2:47635663		S>C	A:112	(-55.07, 44.32, -2.01)
2:47635673		N>K	A:115	(-51.96, 34.83, -0.18)
2:47635690		Y>C	A:121	(-38.64, 32.96, 11.57)
2:47637233		A>T	A:123	(-37.74, 25.16, 15.01)
2:47637234	rs63750210 MMR_c.368delC CD021431	A>V	A:123	(-37.74, 25.16, 15.01)
2:47637239		P>S	A:125	(-36.47, 20.17, 19.46)
2:47637242		G>S	A:126	(-32.40, 20.51, 18.49)
2:47637246	rs17217772	N>S	A:127	(-32.19, 23.72, 15.78)
2:47637248	rs145649774	L>V	A:128	(-33.83, 25.79, 20.00)
2:47637252		S>F	A:129	(-31.12, 28.71, 17.03)
2:47637257		F>V	A:131	(-37.57, 30.97, 18.18)
2:47637275	COSM575530	G>R	A:137	(-35.43, 31.64, 31.13)
2:47637279		N>S	A:138	(-35.24, 28.58, 32.39)
2:47637300		I>T	A:145	(-26.29, 17.83, 22.87)
2:47637301	rs63750124	I>M	A:145	(-26.29, 17.83, 22.87)
2:47637303		G>V	A:146	(-29.35, 17.97, 20.33)
2:47637305		V>I	A:147	(-29.04, 16.76, 16.92)
2:47637306		V>G	A:147	(-29.04, 16.76, 16.92)
2:47637324		S>C	A:153	(-24.12, -0.46, 6.88)
2:47637326		A>T	A:154	(-23.37, -3.59, 5.17)
2:47637336		G>A	A:157	(-20.59, -8.05, 8.80)
2:47637347	rs149511545	V>I	A:161	(-24.32, 1.85, 13.67)
2:47637354	rs63750214 MMR_c.488T>A CM023956 CM033406	V>G	A:163	(-23.47, 7.98, 15.63)
2:47637365	rs63750255	D>H	A:167	(-21.58, 19.45, 22.04)
2:47637367		D>E	A:167	(-21.58, 19.45, 22.04)
2:47637371	rs63750716	I>V	A:169	(-22.88, 23.76, 24.89)
2:47637373		I>M	A:169	(-22.88, 23.76, 24.89)
2:47637374	rs63750843 MMR_c.508C>T CM055994	Q>E	A:170	(-18.85, 21.77, 25.89)
2:47637378	rs63750902	R>K	A:171	(-15.96, 24.73, 21.52)
2:47637387	rs147346837	G>E	A:174	(-19.11, 13.84, 16.72)
2:47637410		D>Y	A:182	(-30.75, -8.42, 16.20)
2:47637422		N>D	A:186	(-25.07, -1.01, 21.51)
2:47637423	rs151129360	N>S	A:186	(-25.07, -1.01, 21.51)
2:47637425		L>V	A:187	(-28.25, 2.75, 19.39)
2:47637431	rs63750821 MMR_c.565G>T	A>T	A:189	(-26.53, 3.20, 25.33)
2:47637432	rs141021599	A>G	A:189	(-26.53, 3.20, 25.33)
2:47637434		L>V	A:190	(-24.89, 5.72, 22.54)
2:47637440	COSM1408246	I>F	A:192	(-29.38, 6.66, 27.38)
2:47637447		I>T	A:194	(-25.70, 11.36, 24.26)
2:47637453	rs63750682 MMR_c.587delC CD051761	P>L	A:196	(-30.49, 13.12, 22.42)
2:47637455	rs146543705	K>Q	A:197	(-34.38, 16.64, 22.57)
2:47637473		G>R	A:203	(-36.09, 7.53, 5.15)
2:47637477		G>E	A:204	(-36.33, 4.07, 4.45)
2:47637486		A>V	A:207	(-38.78, -5.16, 5.17)
2:47637491		D>Y	A:209	(-32.89, -3.62, 10.12)
2:47637496		M>I	A:210	(-34.68, 1.18, 8.59)
2:47637507		R>I	A:214	(-37.95, 4.18, 11.58)
2:47639553	rs63749936 MMR_c.646A>G CM015007	I>L	A:216	(-35.24, 1.57, 19.35)
2:47639556	COSM175285	I>V	A:217	(-34.92, 6.31, 18.03)
2:47639571	COSM330649	I>F	A:222	(-35.73, 10.79, 20.59)
2:47639586		R>G	A:227	(-33.12, 16.22, 6.41)
2:47639589	rs200313142	K>E	A:228	(-34.61, 13.41, 1.47)
2:47639605		S>C	A:233	(-18.89, 11.71, 2.63)
2:47639610		K>E	A:235	(-17.76, 16.40, 3.85)
2:47639632		N>S	A:242	(-14.59, 23.50, 11.27)
2:47639634	rs138857091	R>W	A:243	(-9.26, 23.53, 15.22)
2:47639635	rs63751455	R>Q	A:243	(-9.26, 23.53, 15.22)
2:47639649		K>E	A:248	(-2.82, 29.15, 14.42)
2:47639658	rs147389443	E>K	A:251	(-3.96, 23.46, 11.88)
2:47639662	rs370906735	Q>R	A:252	(-5.64, 23.72, 6.37)
2:47639663		Q>H	A:252	(-5.64, 23.72, 6.37)
2:47639671		S>N	A:255	(-8.35, 17.51, 7.72)
2:47639673	rs377403073	A>T	A:256	(-7.61, 14.01, 5.47)
2:47639682		P>S	A:259	(-7.15, 9.22, 13.25)
2:47639693		E>D	A:262	(-10.99, 4.24, 10.90)
2:47641418	rs563410947	S>L	A:268	(-21.80, 9.77, 6.89)
2:47641423		L>V	A:270	(-21.23, 14.42, 11.15)
2:47641430	rs34136999	A>V	A:272	(-26.57, 15.49, 8.33)
2:47641432	rs530814648 CP044533	V>I	A:273	(-25.78, 17.06, 11.82)
2:47641433	rs144288433	V>A	A:273	(-25.78, 17.06, 11.82)
2:47641435	rs371944271	I>V	A:274	(-22.75, 19.47, 9.09)
2:47641450	rs375351205	L>V	A:279	(-22.49, 24.51, 11.40)
2:47641456		S>P	A:281	(-23.83, 30.27, 7.75)
2:47641459		D>H	A:282	(-22.41, 31.79, 11.32)
2:47641463		D>V	A:283	(-19.10, 34.12, 8.44)
2:47641466		S>Y	A:284	(-15.85, 33.83, 11.92)
2:47641475		G>A	A:287	(-12.97, 27.17, 13.37)
2:47641489	rs104895022	T>S	A:292	(-13.28, 14.81, 21.08)
2:47641500	rs201334592	D>E	A:295	(-15.95, 4.17, 24.32)
2:47641528	rs63751454 MMR_c.913G>A CM970972	A>T	A:305	(-36.38, 0.00, 31.64)
2:47641529		A>E	A:305	(-36.38, 0.00, 31.64)
2:47641540		A>T	A:309	(-37.15, 1.91, 37.19)
2:47641543		L>V	A:310	(-33.90, 3.50, 38.41)
2:47641549	rs267607937 MMR_c.934delC COSM26126	L>V	A:312	(-32.94, 8.39, 36.04)
2:47641553		F>S	A:313	(-33.75, 12.03, 33.94)
2:47643456		G>S	A:322	(-45.24, 10.32, 43.12)
2:47643460	rs63750732 MMR_c.968C>G MMR_c.968C>A CM970973 CM015036	S>C	A:323	(-41.64, 9.52, 43.10)
2:47643466		S>F	A:325	(-36.50, 12.40, 39.88)
2:47643475		A>V	A:328	(-34.65, 16.25, 40.97)
2:47643483	rs267607938 MMR_c.991A>G	N>D	A:331	(-29.52, 18.67, 39.99)
2:47643484		N>S	A:331	(-29.52, 18.67, 39.99)
2:47643513		L>V	A:341	(-21.98, 18.33, 34.88)
2:47643524	rs375799148	Q>H	A:344	(-23.16, 14.59, 31.45)
2:47643535		Q>R	A:348	(-22.07, 9.76, 31.41)
2:47643537	rs267607939 MMR_c.1045C>G CM085559	P>A	A:349	(-22.39, 5.98, 34.90)
2:47643540		L>F	A:350	(-17.86, 6.67, 36.52)
2:47643543	rs138026880	M>V	A:351	(-16.92, 1.86, 34.61)
2:47643559		I>T	A:356	(-15.56, 6.57, 41.30)
2:47643568	rs63751604 MMR_c.1076G>T	R>K	A:359	(-16.65, 12.37, 41.00)
2:47656891	rs377345366	V>L	A:363	(-18.31, 14.82, 48.26)
2:47656904		V>A	A:367	(-20.16, 16.11, 53.87)
2:47656913	rs139652783	A>V	A:370	(-20.68, 22.68, 56.55)
2:47656916		E>G	A:371	(-18.50, 26.21, 58.04)
2:47656918		L>V	A:372	(-17.08, 25.11, 52.65)
2:47656925		Q>R	A:374	(-23.62, 27.07, 54.93)
2:47656926	rs370378607	Q>H	A:374	(-23.62, 27.07, 54.93)
2:47656928		T>I	A:375	(-20.44, 29.90, 52.16)
2:47656931		L>S	A:376	(-20.00, 28.02, 48.26)
2:47656933	rs63750267 MMR_c.1129C>T CM064122	Q>E	A:377	(-25.59, 26.18, 48.45)
2:47656934		Q>R	A:377	(-25.59, 26.18, 48.45)
2:47656939	COSM176654	D>Y	A:379	(-24.28, 32.92, 50.19)
2:47656948		R>C	A:382	(-26.63, 33.54, 44.85)
2:47656952	rs376934727	R>Q	A:383	(-23.21, 35.96, 44.42)
2:47656957		P>S	A:385	(-22.63, 33.87, 35.44)
2:47656963		L>F	A:387	(-19.46, 31.53, 31.76)
2:47656970		R>Q	A:389	(-26.20, 31.51, 28.93)
2:47656972	rs17224367	L>F	A:390	(-21.44, 35.40, 28.21)
2:47656979	rs61756465	K>M	A:392	(-22.03, 31.03, 21.95)
2:47656986	rs374135434	F>L	A:394	(-18.45, 38.22, 24.21)
2:47656988		Q>R	A:395	(-17.50, 33.50, 19.01)
2:47656993	rs63750611	Q>E	A:397	(-18.74, 40.16, 17.88)
2:47657008	rs63751412 rs63751413 MMR_c.1204C>T MMR_c.1204delC CD092671 CM060079	Q>K	A:402	(-25.50, 44.29, 30.63)
2:47657021	rs146567853	R>Q	A:406	(-24.47, 39.43, 33.79)
2:47657027	rs63750379 MMR_c.1223A>G CM066580	Y>F	A:408	(-16.41, 43.23, 37.31)
2:47657035		I>L	A:411	(-14.53, 37.81, 37.69)
2:47657042	COSM1408257	Q>P	A:413	(-18.13, 37.61, 44.00)
2:47657047	rs35717997	P>A	A:415	(-11.66, 36.32, 44.82)
2:47657056		I>L	A:418	(-10.12, 31.60, 46.79)
2:47657058		I>M	A:418	(-10.12, 31.60, 46.79)
2:47657059	rs186103499	Q>K	A:419	(-10.58, 34.26, 50.80)
2:47657062		A>P	A:420	(-13.20, 29.86, 51.68)
2:47657071	rs201059765	K>E	A:423	(-10.61, 28.84, 55.59)
2:47657072		K>R	A:423	(-10.61, 28.84, 55.59)
2:47672694		H>Q	A:428	(-9.26, 16.02, 56.07)
2:47672711		A>V	A:434	(-5.41, 21.53, 43.46)
2:47672726	COSM1684713 CD042877	P>L	A:439	(-7.29, 26.29, 39.19)
2:47672731		T>P	A:441	(-5.58, 31.56, 41.50)
2:47672741	rs557339938	R>L	A:444	(-7.53, 36.98, 40.58)
2:47672748		D>E	A:446	(-6.00, 34.70, 33.63)
2:47672770		I>L	A:454	(-14.55, 47.22, 33.39)
2:47672776		T>A	A:456	(-10.96, 52.41, 34.12)
2:47672777		T>I	A:456	(-10.96, 52.41, 34.12)
2:47672788	rs575905950	M>V	A:460	(-20.53, 51.88, 40.32)
2:47672790		M>I	A:460	(-20.53, 51.88, 40.32)
2:47672792		D>A	A:461	(-22.30, 55.75, 40.35)
2:47690174		E>G	A:464	(-25.85, 50.71, 40.99)
2:47690180	rs544265737	H>R	A:466	(-32.42, 51.18, 34.85)
2:47690188		L>V	A:469	(-23.02, 54.63, 30.24)
2:47690201	rs63751403 MMR_c.1418C>G MMR_c.1418C>T CM004654 CM031248	S>L	A:473	(-13.52, 60.75, 33.34)
2:47690218		S>R	A:479	(-14.45, 65.30, 28.77)
2:47690219	rs555986369	S>N	A:479	(-14.45, 65.30, 28.77)
2:47690220		S>R	A:479	(-14.45, 65.30, 28.77)
2:47690236		M>V	A:485	(-23.99, 68.69, 26.81)
2:47690244	rs35107951	D>E	A:487	(-21.80, 74.83, 29.41)
2:47690245		L>V	A:488	(-25.68, 74.30, 26.27)
2:47690257		M>L	A:492	(-31.28, 76.00, 28.42)
2:47690261	rs376990143	Q>L	A:493	(-31.28, 76.99, 33.69)
2:47690263	rs55653533	S>P	A:494	(-30.47, 81.56, 30.91)
2:47690264	rs370970617 CD103488	S>L	A:494	(-30.47, 81.56, 30.91)
2:47690267		T>I	A:495	(-33.27, 81.18, 28.54)
2:47690272		I>V	A:497	(-34.31, 83.68, 34.32)
2:47690285	rs376677710	R>K	A:501	(-37.23, 89.88, 33.15)
2:47690288	rs148192104	D>G	A:502	(-40.56, 88.45, 28.39)
2:47693816	COSM1483118	Q>H	A:510	(-45.54, 79.30, 37.12)
2:47693839		Q>L	A:518	(-41.20, 63.72, 20.88)
2:47693856		R>C	A:524	(-44.07, 72.56, 30.92)
2:47693881		V>A	A:532	(-48.71, 82.29, 23.83)
2:47693896		K>T	A:537	(-42.63, 89.07, 23.54)
2:47693917		I>T	A:544	(-51.27, 70.74, 23.41)
2:47693926	rs267607967 MMR_c.1640A>G	N>S	A:547	(-48.26, 68.24, 31.16)
2:47693943		N>Y	A:553	(-37.19, 80.89, 21.79)
2:47693947	rs63750597 MMR_c.1661G>C CS042820	S>N	A:554	(-35.56, 82.11, 18.53)
2:47698112	rs139920308	T>S	A:557	(-34.92, 76.30, 18.38)
2:47698117		L>I	A:559	(-29.49, 76.40, 21.97)
2:47698123	rs63750328 MMR_c.1681G>A COSM1021249 CM068371	E>K	A:561	(-31.10, 72.39, 16.08)
2:47698127	rs63750997 MMR_c.1685A>T CM970974	E>V	A:562	(-25.29, 73.38, 18.41)
2:47698132	rs55778204	T>A	A:564	(-29.23, 67.15, 19.20)
2:47698141	rs63751149 MMR_c.1699A>T	K>E	A:567	(-27.47, 63.83, 22.26)
2:47698151		Y>C	A:570	(-21.21, 61.14, 24.40)
2:47698157		E>A	A:572	(-20.83, 58.59, 16.78)
2:47698159	rs200766962 rs267607974 MMR_c.1717delG CD085025	A>T	A:573	(-18.33, 57.36, 20.50)
2:47698166	rs370330868	D>G	A:575	(-21.16, 52.67, 20.28)
2:47698171		I>V	A:577	(-15.14, 53.04, 22.90)
2:47698172	rs149796110	I>T	A:577	(-15.14, 53.04, 22.90)
2:47698182		E>D	A:580	(-11.86, 48.01, 21.24)
2:47698183		I>V	A:581	(-14.80, 47.24, 25.41)
2:47702174		E>D	A:590	(-9.58, 30.11, 25.31)
2:47702178	rs371614039	M>V	A:592	(-15.19, 32.46, 29.59)
2:47702184		T>A	A:594	(-11.87, 27.13, 31.61)
2:47702191	rs147842583	N>S	A:596	(-18.16, 27.06, 32.72)
2:47702193		D>N	A:597	(-15.91, 23.53, 32.56)
2:47702194	rs548407418	D>A	A:597	(-15.91, 23.53, 32.56)
2:47702196		V>M	A:598	(-14.05, 24.60, 37.16)
2:47702200		L>S	A:599	(-17.44, 27.17, 38.49)
2:47702202		A>T	A:600	(-19.51, 23.09, 37.20)
2:47702206		Q>R	A:601	(-16.21, 20.38, 37.96)
2:47702208		L>V	A:602	(-17.40, 23.49, 42.80)
2:47702221	rs376044376	V>D	A:606	(-21.62, 21.48, 46.58)
2:47702223		S>G	A:607	(-25.06, 19.35, 45.18)
2:47702229	rs150980616	A>S	A:609	(-23.25, 17.34, 49.65)
2:47702235	rs369385048	V>M	A:611	(-28.77, 16.20, 48.82)
2:47702241	rs200147804	N>H	A:613	(-26.49, 16.46, 54.69)
2:47702248		A>V	A:615	(-31.62, 13.21, 54.45)
2:47702251		P>R	A:616	(-34.03, 11.19, 56.10)
2:47702260	rs63749982	Y>C	A:619	(-27.50, 9.98, 51.50)
2:47702265	rs63750508 MMR_c.1861C>T COSM3839607 CM960990	R>G	A:621	(-17.36, 6.87, 51.11)
2:47702266		R>Q	A:621	(-17.36, 6.87, 51.11)
2:47702272		A>G	A:623	(-17.02, 0.64, 48.82)
2:47702286	rs371776176	G>R	A:628	(-16.73, -7.64, 38.92)
2:47702290	rs61756468	Q>R	A:629	(-14.33, -8.38, 42.93)
2:47702297		R>S	A:631	(-17.98, -7.65, 48.12)
2:47702301		I>V	A:633	(-22.79, -5.67, 51.16)
2:47702310	rs63750875	A>P	A:636	(-29.89, 0.19, 55.77)
2:47702311	rs63750279	A>V	A:636	(-29.89, 0.19, 55.77)
2:47702322	rs531276135	A>S	A:640	(-33.77, 8.11, 47.47)
2:47702328		V>I	A:642	(-39.88, 6.76, 48.20)
2:47702337	rs267607982 MMR_c.1933C>G	Q>E	A:645	(-43.09, 9.83, 48.24)
2:47702341	rs41295290	D>A	A:646	(-46.09, 12.46, 51.02)
2:47702367	rs549467183	V>I	A:655	(-28.82, -5.74, 49.80)
2:47702371	rs185356145	Y>C	A:656	(-25.43, -10.87, 50.72)
2:47702377	rs200827721	E>G	A:658	(-21.13, -12.99, 48.14)
2:47703509	rs41294982	P>L	A:670	(-48.28, -8.98, 49.18)
2:47703514		M>V	A:672	(-49.04, -2.42, 48.29)
2:47703548		G>A	A:683	(-30.37, 0.23, 41.51)
2:47703564	rs63750790	M>I	A:688	(-26.35, 6.90, 43.71)
2:47703572		I>T	A:691	(-22.83, 9.31, 40.13)
2:47703573		I>M	A:691	(-22.83, 9.31, 40.13)
2:47703583		V>L	A:695	(-25.40, 5.77, 49.46)
2:47703601	COSM1738062 CM101612	E>K	A:701	(-19.53, -3.19, 50.51)
2:47703610		I>V	A:704	(-17.77, -1.35, 39.26)
2:47703611	rs564657106	I>T	A:704	(-17.77, -1.35, 39.26)
2:47703618		D>E	A:706	(-21.09, -4.05, 32.65)
2:47703622		I>V	A:708	(-28.27, -1.35, 35.26)
2:47703629	rs373717132	A>G	A:710	(-34.58, -4.00, 32.86)
2:47703632	rs138465383	R>Q	A:711	(-39.70, -6.40, 32.27)
2:47703671	rs63751125 MMR_c.2171C>A	T>M	A:724	(-48.14, -6.55, 24.44)
2:47703678		M>I	A:726	(-43.17, -10.25, 21.79)
2:47703695		T>S	A:732	(-35.83, -10.68, 27.80)
2:47703697		A>T	A:733	(-33.25, -11.62, 24.72)
2:47703703	rs2229061	I>V	A:735	(-31.20, -8.62, 28.96)
2:47705466		T>A	A:756	(-50.27, -19.99, 33.78)
2:47705467	rs372383829	T>S	A:756	(-50.27, -19.99, 33.78)
2:47705470		Y>S	A:757	(-50.08, -24.41, 32.88)
2:47705496	rs374399939	I>V	A:766	(-35.53, -16.85, 31.77)
2:47705508	rs63750684	I>V	A:770	(-29.97, -15.44, 34.46)
2:47705509	rs371718349	I>T	A:770	(-29.97, -15.44, 34.46)
2:47705520		I>F	A:774	(-25.34, -15.29, 32.58)
2:47705537	rs41295292	M>I	A:779	(-33.24, -8.60, 42.13)
2:47705554	rs200252727	H>P	A:785	(-47.31, -20.02, 43.10)
2:47705562		T>P	A:788	(-39.75, -20.54, 45.04)
2:47705575		N>S	A:792	(-34.54, -25.74, 46.50)
2:47705579		Q>H	A:793	(-32.73, -26.90, 41.82)
2:47705594		N>K	A:798	(-32.21, -16.78, 47.85)
2:47705597	rs368988823	N>K	A:799	(-36.07, -17.41, 48.23)
2:47705617		T>I	A:806	(-53.96, -10.15, 59.33)
2:47705620	rs41295294 MMR_c.2420C>G	T>I	A:807	(-57.18, -8.57, 61.53)
2:47705625	rs202145681	E>K	A:809	(-62.05, -4.99, 60.10)
2:47705637	rs63749841 MMR_c.2437A>G CM023960	M>V	A:813	(-48.29, -3.82, 54.27)
2:47705639		M>I	A:813	(-48.29, -3.82, 54.27)
2:47705647		Q>R	A:816	(-38.46, -5.31, 56.86)
2:47707859		I>S	A:828	(-58.57, -14.95, 50.17)
2:47707872		E>D	A:832	(-63.16, -10.79, 53.94)
2:47707876	rs63750757	A>T	A:834	(-64.01, -5.74, 49.59)
2:47707880		N>S	A:835	(-68.09, -6.89, 50.88)
2:47707892	rs63750027	H>R	A:839	(-71.88, -17.43, 49.17)
2:47707893	rs267608016 MMR_c.2517T>A	H>Q	A:839	(-71.88, -17.43, 49.17)
2:47707904		C>Y	A:843	(-65.51, -21.11, 47.41)
2:47707909	rs63750571	K>E	A:845	(-61.61, -20.17, 52.32)
2:47707913	rs140754514	Q>R	A:846	(-63.35, -25.06, 49.82)
2:47707927	rs267608015 MMR_c.2551C>A	L>I	A:851	(-54.10, -25.43, 44.94)
2:47707934	rs63750797	E>A	A:853	(-52.96, -30.57, 47.61)
2:47707937		F>C	A:854	(-50.91, -29.54, 44.04)

[+] ClinVar Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:47630334	rs63750466	A>T	A:2	(-54.81, 31.99, 28.14)
2:47630358	rs63751099	Q>K	A:10	(-61.58, 40.97, 10.16)
2:47630410	rs750746034	P>L	A:27	(-46.26, 21.31, 1.37)
2:47630412	rs63751246	E>K	A:28	(-47.64, 16.03, 3.11)
2:47630490	rs749212640	A>S	A:54	(-57.46, 25.00, 21.17)
2:47630493	rs587782354	R>G	A:55	(-56.44, 20.30, 22.13)
2:47630512	rs587779113	Q>P	A:61	(-63.25, 23.28, 20.38)
2:47630541	rs587782659	G>R	A:71	(-71.12, 28.17, 1.59)
2:47635588	rs587781447	S>C	A:87	(-46.62, 30.03, 25.30)
2:47635605	rs63751429	L>F	A:93	(-39.79, 23.54, 20.96)
2:47637246	rs17217772	N>I	A:127	(-32.19, 23.72, 15.78)
2:47637350	rs63750624	G>R	A:162	(-23.35, 5.54, 12.66)
2:47637354	rs63750214	V>D	A:163	(-23.47, 7.98, 15.63)
2:47637356	rs63750582	G>R	A:164	(-23.31, 11.75, 14.67)
2:47637359	rs587779163	Y>D	A:165	(-21.79, 13.86, 18.75)
2:47637395	rs63750382	E>K	A:177	(-18.14, 3.28, 13.77)
2:47637426	rs63751444	L>P	A:187	(-28.25, 2.75, 19.39)
2:47637461	rs63751110	C>R	A:199	(-32.72, 11.94, 15.16)
2:47639554	rs786203108	I>T	A:216	(-35.24, 1.57, 19.35)
2:47639608	rs730881773	T>I	A:234	(-18.28, 14.32, -0.48)
2:47639623	rs199676483	Q>R	A:239	(-14.77, 18.50, 6.86)
2:47639673	rs377403073	A>T	A:256	(-7.61, 14.01, 5.47)
2:47639689	rs63749969	M>T	A:261	(-11.91, 10.04, 9.24)
2:47639699	rs587779183	Q>H	A:264	(-17.25, 6.12, 7.47)
2:47641450	rs375351205	L>V	A:279	(-22.49, 24.51, 11.40)
2:47641509	rs587781397	Q>H	A:298	(-15.13, 4.58, 28.63)
2:47641544	rs63750640	L>P	A:310	(-33.90, 3.50, 38.41)
2:47643481	rs63750630	L>P	A:330	(-29.22, 14.30, 43.31)
2:47643490	rs63750828	C>Y	A:333	(-27.16, 22.98, 41.07)
2:47643505	rs587779065	G>E	A:338	(-24.10, 22.36, 36.86)
2:47643514	rs63751147	L>P	A:341	(-21.98, 18.33, 34.88)
2:47643538	rs587779067	P>L	A:349	(-22.39, 5.98, 34.90)
2:47643568	rs63751604	R>K	A:359	(-16.65, 12.37, 41.00)
2:47656972	rs17224367	L>F	A:390	(-21.44, 35.40, 28.21)
2:47657029	rs151244108	Q>K	A:409	(-20.99, 41.22, 39.37)
2:47657074	rs587782278	H>Y	A:424	(-10.15, 23.52, 54.26)
2:47672725	rs786203116	P>S	A:439	(-7.29, 26.29, 39.19)
2:47672729	rs587779084	L>P	A:440	(-10.18, 29.19, 40.76)
2:47672768	rs63750697	M>K	A:453	(-11.07, 47.22, 30.83)
2:47690201	rs63751403	S>L	A:473	(-13.52, 60.75, 33.34)
2:47690264	rs370970617	S>L	A:494	(-30.47, 81.56, 30.91)
2:47690293	rs63751600	G>C	A:504	(-44.38, 86.91, 34.38)
2:47693947	rs63750597	S>N	A:554	(-35.56, 82.11, 18.53)
2:47698123	rs63750328	E>K	A:561	(-31.10, 72.39, 16.08)
2:47698128	rs786203850	E>D	A:562	(-25.29, 73.38, 18.41)
2:47698159	rs200766962	A>T	A:573	(-18.33, 57.36, 20.50)
2:47698201	rs63751140	G>R	A:587	(-10.15, 37.42, 24.24)
2:47702188	rs786201590	L>R	A:595	(-14.30, 29.69, 34.96)
2:47702191	rs41295288	N>S	A:596	(-18.16, 27.06, 32.72)
2:47702212	rs267607985	D>G	A:603	(-22.32, 23.59, 41.50)
2:47702230	rs63750665	A>V	A:609	(-23.25, 17.34, 49.65)
2:47702260	rs63749982	Y>C	A:619	(-27.50, 9.98, 51.50)
2:47702269	rs28929483	P>L	A:622	(-19.37, 4.04, 48.86)
2:47702310	rs63750875	A>P	A:636	(-29.89, 0.19, 55.77)
2:47702319	rs28929484	H>Y	A:639	(-36.06, 4.67, 46.62)
2:47702359	rs267607983	P>H	A:652	(-35.10, 0.33, 56.48)
2:47702409	rs63751668	G>S	A:669	(-45.94, -11.00, 47.83)
2:47703520	rs63750234	G>S	A:674	(-42.32, -3.83, 48.23)
2:47703521	rs267607996	G>D	A:674	(-42.32, -3.83, 48.23)
2:47703545	rs587779130	T>I	A:682	(-30.92, -2.00, 44.61)
2:47703547	rs267607995	G>R	A:683	(-30.37, 0.23, 41.51)
2:47703560	rs587779133	L>P	A:687	(-26.52, 4.56, 39.42)
2:47703563	rs63749993	M>R	A:688	(-26.35, 6.90, 43.71)
2:47703568	rs587779134	Q>E	A:690	(-20.97, 3.80, 39.41)
2:47703574	rs63750232	G>R	A:692	(-20.01, 10.00, 43.04)
2:47703587	rs267607994	P>L	A:696	(-28.97, 5.83, 50.88)
2:47703589	rs63750961	C>R	A:697	(-26.83, 3.47, 53.61)
2:47703703	rs2229061	I>V	A:735	(-31.20, -8.62, 28.96)
2:47705445	rs63751477	E>K	A:749	(-44.75, -9.49, 37.91)
2:47705451	rs63751119	G>R	A:751	(-45.60, -13.86, 32.85)
2:47705460	rs757268664	T>S	A:754	(-49.45, -15.66, 28.61)
2:47705493	rs63750368	A>T	A:765	(-35.99, -20.94, 32.12)
2:47707876	rs63750757	A>T	A:834	(-64.01, -5.74, 49.59)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
2:47643457	COSM26086	G>D	A:322	(-45.24, 10.32, 43.12)
2:47643546	COSM1197112	D>H	A:352	(-12.50, 3.71, 36.09)
2:47657021	COSM168419	R>Q	A:406	(-24.47, 39.43, 33.79)
2:47690183	COSM1408258	E>G	A:467	(-28.32, 53.12, 32.10)
2:47698201	COSM1408262	G>C	A:587	(-10.15, 37.42, 24.24)
2:47703527	COSM1614880	S>L	A:676	(-41.19, -3.05, 43.04)
2:47703560	COSM1408265	L>P	A:687	(-26.52, 4.56, 39.42)
2:47707838	COSM1408274	V>A	A:821	(-41.25, -18.24, 51.42)
2:47707841	COSM21723	C>F	A:822	(-44.70, -16.88, 53.36)
2:47707855	COSM26097	G>R	A:827	(-55.88, -12.39, 49.01)

2O8B.A | MSH2.

2O8B.A | MSH2

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Pathogenic Proximity Analysis

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants