General Structure Information
| PDB ID | 1iil |
| HGNC Gene Label(s) | FGFR2 |
| Structure Name | crystal structure of pro253arg apert mutant fgf receptor 2 (fgfr2) in complex with fgf2 |
| Resolution | 2.3Å |
| Reference | AUTH O.A.IBRAHIMI,A.V.ELISEENKOVA,A.N.PLOTNIKOV,K.YU,AUTH 2 D.M.ORNITZ,M.MOHAMMADITITL STRUCTURAL BASIS FOR FIBROBLAST GROWTH FACTORTITL 2 RECEPTOR 2 ACTIVATION IN APERT SYNDROME.REF PROC.NATL.ACAD.SCI.USA V. 98 7182 2001REFN ISSN 0027-8424PMID 11390973DOI 10.1073/PNAS.121183798 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 215 |
| Number Of SNVs | 31 |
| Number Of Permutations | 12336 |
| Optimal Distance Threshold | 33.0 |
| K Statistic | 0.475 |
| p-value | 0.707 |
ClinVar
| Number Of Residues | 215 |
| Number Of SNVs | 17 |
| Number Of Permutations | 6900 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.904 |
| p-value | 0.0 |
COSMIC
| Number Of Residues | 215 |
| Number Of SNVs | 7 |
| Number Of Permutations | 6578 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.095 |
| p-value | 0.248 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of ClinVar SNVs | 16 |
| Optimal Distance Threshold | 27.0 |
| K Statistic | 0.481 |
| p-value | 0.0 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 9 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | -0.136 |
| p-value | 0.789 |