General Structure Information
| PDB ID | 2gl7 |
| HGNC Gene Label(s) | CTNNB1 |
| Structure Name | crystal structure of a beta-catenin/bcl9/tcf4 complex |
| Resolution | 2.6Å |
| Reference | AUTH J.SAMPIETRO,C.L.DAHLBERG,U.S.CHO,T.R.HINDS,D.KIMELMAN,W.XUTITL CRYSTAL STRUCTURE OF A BETA-CATENIN/BCL9/TCF4 COMPLEX.REF MOL.CELL V. 24 293 2006REFN ISSN 1097-2765PMID 17052462DOI 10.1016/J.MOLCEL.2006.09.001 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 512 |
| Number Of SNVs | 54 |
| Number Of Permutations | 53833 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.205 |
| p-value | 0.064 |
COSMIC
| Number Of Residues | 512 |
| Number Of SNVs | 18 |
| Number Of Permutations | 25535 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.02 |
| p-value | 0.135 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 54 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 28.0 |
| K Statistic | 0.132 |
| p-value | 0.555 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
