General Structure Information
| PDB ID | 3whw |
| HGNC Gene Label(s) | NUDT1 |
| Structure Name | mth1 in complex with ruthenium-based inhibitor |
| Resolution | 2.7Å |
| Reference | AUTH M.STREIB,K.KRAELING,K.RICHTER,X.XIE,H.STEUBER,E.MEGGERSTITL AN ORGANOMETALLIC INHIBITOR FOR THE HUMAN REPAIR ENZYMETITL 2 7,8-DIHYDRO-8-OXOGUANOSINE TRIPHOSPHATASE.REF ANGEW.CHEM.INT.ED.ENGL. V. 53 305 2014REFN ISSN 1433-7851PMID 24258965DOI 10.1002/ANIE.201307849 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 154 |
| Number Of SNVs | 55 |
| Number Of Permutations | 13002 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.058 |
| p-value | 0.692 |
COSMIC
| Number Of Residues | 154 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.2 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 55 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.165 |
| p-value | 0.97 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
