General Structure Information
| PDB ID | 4djh |
| HGNC Gene Label(s) | OPRK1 |
| Structure Name | structure of the human kappa opioid receptor in complex with jdtic |
| Resolution | 2.9Å |
| Reference | AUTH H.WU,D.WACKER,M.MILENI,V.KATRITCH,G.W.HAN,E.VARDY,W.LIU,AUTH 2 A.A.THOMPSON,X.P.HUANG,F.I.CARROLL,S.W.MASCARELLA,AUTH 3 R.B.WESTKAEMPER,P.D.MOSIER,B.L.ROTH,V.CHEREZOV,R.C.STEVENSTITL TRUCTURE OF THE HUMAN KAPPA-OPIOID RECEPTOR IN COMPLEX WITHTITL 2 JDTICREF NATURE V. 485 327 2012REFN ISSN 0028-0836PMID 22437504DOI 10.1038/NATURE10939 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 287 |
| Number Of SNVs | 82 |
| Number Of Permutations | 24335 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.126 |
| p-value | 0.55 |
COSMIC
| Number Of Residues | 287 |
| Number Of SNVs | 14 |
| Number Of Permutations | 3723 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.011 |
| p-value | 0.764 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 82 |
| Number Of COSMIC SNVs | 12 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | -0.017 |
| p-value | 0.841 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
