Assessment of Structural Intolerance and Durability
General Structure Information 3e0g LIFR structure of the leukemia inhibitory factor receptor (lif-r) domains d1-d5 3.1Å AUTH G.SKINIOTIS,P.J.LUPARDUS,M.MARTICK,T.WALZ,K.C.GARCIATITL STRUCTURAL ORGANIZATION OF A FULL-LENGTH GP130/LIF-RTITL 2 CYTOKINE RECEPTOR TRANSMEMBRANE COMPLEX.REF MOL.CELL V. 31 737 2008REFN ISSN 1097-2765PMID 18775332DOI 10.1016/J.MOLCEL.2008.08.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3pbl DRD3 structure of the human dopamine d3 receptor in complex with eticlopride 2.89Å AUTH E.Y.CHIEN,W.LIU,Q.ZHAO,V.KATRITCH,G.W.HAN,M.A.HANSON,L.SHI,AUTH 2 A.H.NEWMAN,J.A.JAVITCH,V.CHEREZOV,R.C.STEVENSTITL STRUCTURE OF THE HUMAN DOPAMINE D3 RECEPTOR IN COMPLEX WITHTITL 2 A D2/D3 SELECTIVE ANTAGONIST.REF SCIENCE V. 330 1091 2010REFN ISSN 0036-8075PMID 21097933DOI 10.1126/SCIENCE.1197410 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3npc MAPK9 crystal structure of jnk2 complexed with birb796 2.35Å AUTH A.KUGLSTATTER,M.GHATE,S.TSING,A.G.VILLASENOR,D.SHAW,AUTH 2 J.W.BARNETT,M.F.BROWNERTITL X-RAY CRYSTAL STRUCTURE OF JNK2 COMPLEXED WITH THE P38ALPHATITL 2 INHIBITOR BIRB796: INSIGHTS INTO THE RATIONAL DESIGN OFTITL 3 DFG-OUT BINDING MAP KINASE INHIBITORS.REF BIOORG.MED.CHEM.LETT. V. 20 5217 2010REFN ISSN 0960-894XPMID 20655210DOI 10.1016/J.BMCL.2010.06.157 Variant Set Distributions Ripley’s K […]
General Structure Information 3zwh MYH9 ca2+-bound s100a4 c3s, c81s, c86s and f45w mutant complexed with myosin iia 1.94Å AUTH B.KISS,A.DUELLI,L.RADNAI,K.A.KEKESI,G.KATONA,L.NYITRAYTITL CRYSTAL STRUCTURE OF THE S100A4-NONMUSCLE MYOSIN IIA TAILTITL 2 FRAGMENT COMPLEX REVEALS AN ASYMMETRIC TARGET BINDINGTITL 3 MECHANISM.REF PROC.NATL.ACAD.SCI.USA V. 109 6048 2012REFN ISSN 0027-8424PMID 22460785DOI 10.1073/PNAS.1114732109 Variant Set Distributions Mapped Variants
General Structure Information 1g82 FGF9 structure of fibroblast growth factor 9 2.6Å AUTH H.J.HECHT,R.ADAR,B.HOFMANN,O.BOGIN,H.WEICH,A.YAYONTITL STRUCTURE OF FIBROBLAST GROWTH FACTOR 9 SHOWS A SYMMETRICTITL 2 DIMER WITH UNIQUE RECEPTOR- AND HEPARIN-BINDING INTERFACES.REF ACTA CRYSTALLOGR.,SECT.D V. 57 378 2001REFN ISSN 0907-4449PMID 11223514DOI 10.1107/S0907444900020813 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1v7n THPO human thrombopoietin functional domain complexed to neutralizing antibody tn1 fab 3.3Å AUTH M.D.FEESE,T.TAMADA,Y.KATO,Y.MAEDA,M.HIROSE,AUTH 2 Y.MATSUKURA,H.SHIGEMATSU,T.MUTO,A.MATSUMOTO,AUTH 3 H.WATARAI,K.OGAMI,T.TAHARA,T.KATO,H.MIYAZAKI,AUTH 4 R.KUROKITITL STRUCTURE OF THE RECEPTOR-BINDING DOMAIN OF HUMANTITL 2 THROMBOPOIETIN DETERMINED BY COMPLEXATION WITH ATITL 3 NEUTRALIZING ANTIBODY FRAGMENTREF PROC.NATL.ACAD.SCI.USA V. 101 1816 2004REFN ISSN 0027-8424PMID 14769915DOI 10.1073/PNAS.0308530100 Variant Set Distributions Mapped […]
General Structure Information 1cp3 CASP3 crystal structure of the complex of apopain with the tetrapeptide inhibitor ace-dvad-fmc 2.3Å AUTH P.R.MITTL,S.DI MARCO,J.F.KREBS,X.BAI,D.S.KARANEWSKY,AUTH 2 J.P.PRIESTLE,K.J.TOMASELLI,M.G.GRUTTERTITL STRUCTURE OF RECOMBINANT HUMAN CPP32 IN COMPLEX WITH THETITL 2 TETRAPEPTIDE ACETYL-ASP-VAL-ALA-ASP FLUOROMETHYL KETONE.REF J.BIOL.CHEM. V. 272 6539 1997REFN ISSN 0021-9258PMID 9045680DOI 10.1074/JBC.272.10.6539 Variant Set Distributions Mapped Variants
General Structure Information 4dbu AKR1C3 crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid 2.53Å AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF […]
General Structure Information 1d6g CCKAR molecular complex of cholecystokinin-8 and n-terminus of the cholecystokinin a receptor by nmr spectroscopy -1.0Å AUTH M.PELLEGRINI,D.F.MIERKETITL MOLECULAR COMPLEX OF CHOLECYSTOKININ-8 ANDTITL 2 N-TERMINUS OF THE CHOLECYSTOKININ A RECEPTOR BYTITL 3 NMR SPECTROSCOPY.REF BIOCHEMISTRY V. 38 14775 1999REFN ISSN 0006-2960PMID 10555959DOI 10.1021/BI991272L Variant Set Distributions Mapped Variants
General Structure Information 2hev TNFRSF4 crystal structure of the complex between ox40l and ox40 2.41Å AUTH D.M.COMPAAN,S.G.HYMOWITZTITL THE CRYSTAL STRUCTURE OF THE COSTIMULATORY OX40-OX40LTITL 2 COMPLEX.REF STRUCTURE V. 14 1321 2006REFN ISSN 0969-2126PMID 16905106DOI 10.1016/J.STR.2006.06.015 Variant Set Distributions Mapped Variants