General Structure Information
| PDB ID | 4dbu |
| HGNC Gene Label(s) | AKR1C3 |
| Structure Name | crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 (akr1c3) in complex with nadp+ and 3-((4 -(trifluoromethyl)phenyl) amino)benzoic acid |
| Resolution | 2.53Å |
| Reference | AUTH M.CHEN,A.O.ADENIJI,B.M.TWENTER,J.D.WINKLER,D.W.CHRISTIANSON,AUTH 2 T.M.PENNINGTITL CRYSTAL STRUCTURES OF AKR1C3 CONTAINING ANTITL 2 N-(ARYL)AMINO-BENZOATE INHIBITOR AND A BIFUNCTIONAL AKR1C3TITL 3 INHIBITOR AND ANDROGEN RECEPTOR ANTAGONIST. THERAPEUTICTITL 4 LEADS FOR CASTRATE RESISTANT PROSTATE CANCER.REF BIOORG.MED.CHEM.LETT. V. 22 3492 2012REFN ISSN 0960-894XPMID 22507964DOI 10.1016/J.BMCL.2012.03.085 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 315 |
| Number Of SNVs | 89 |
| Number Of Permutations | 10673 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.116 |
| p-value | 0.017 |
COSMIC
| Number Of Residues | 315 |
| Number Of SNVs | 4 |
| Number Of Permutations | 1417 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.667 |
| p-value | 0.631 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 89 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | -0.398 |
| p-value | 0.613 |