General Structure Information
| PDB ID | 2no3 |
| HGNC Gene Label(s) | MAPK8 |
| Structure Name | novel 4-anilinopyrimidines as potent jnk1 inhibitors |
| Resolution | 3.2Å |
| Reference | AUTH M.LIU,S.WANG,J.E.CLAMPIT,R.J.GUM,D.L.HAASCH,AUTH 2 C.M.RONDINONE,J.M.TREVILLYAN,C.ABAD-ZAPATERO,AUTH 3 E.H.FRY,H.L.SHAM,G.LIUTITL DISCOVERY OF A NEW CLASS OF 4-ANILINOPYRIMIDINESTITL 2 AS POTENT C-JUN N-TERMINAL KINASE INHIBITORS:TITL 3 SYNTHESIS AND SAR STUDIES.REF BIOORG.MED.CHEM.LETT. V. 17 668 2007REFN ISSN 0960-894XPMID 17107797DOI 10.1016/J.BMCL.2006.10.093 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 357 |
| Number Of SNVs | 41 |
| Number Of Permutations | 7492 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.307 |
| p-value | 0.679 |
COSMIC
| Number Of Residues | 357 |
| Number Of SNVs | 6 |
| Number Of Permutations | 1294 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.067 |
| p-value | 0.462 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 41 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.145 |
| p-value | 0.526 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
