Assessment of Structural Intolerance and Durability
General Structure Information 1axi GH1 structural plasticity at the hgh:hghbp interface 2.1Å AUTH S.ATWELL,M.ULTSCH,A.M.DE VOS,J.A.WELLSTITL STRUCTURAL PLASTICITY IN A REMODELED PROTEIN-PROTEINTITL 2 INTERFACE.REF SCIENCE V. 278 1125 1997REFN ISSN 0036-8075PMID 9353194DOI 10.1126/SCIENCE.278.5340.1125 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2lwi HRAS solution structure of h-rast35s mutant protein in complex with kobe2601 -1.0Å AUTH F.SHIMA,Y.YOSHIKAWA,M.YE,M.ARAKI,S.MATSUMOTO,J.LIAO,L.HU,AUTH 2 T.SUGIMOTO,Y.IJIRI,A.TAKEDA,Y.NISHIYAMA,C.SATO,S.MURAOKA,AUTH 3 A.TAMURA,T.OSODA,K.I.TSUDA,T.MIYAKAWA,H.FUKUNISHI,J.SHIMADA,AUTH 4 T.KUMASAKA,M.YAMAMOTO,T.KATAOKATITL IN SILICO DISCOVERY OF SMALL-MOLECULE RAS INHIBITORS THATTITL 2 DISPLAY ANTITUMOR ACTIVITY BY BLOCKING THE RAS-EFFECTORTITL 3 INTERACTION.REF PROC.NATL.ACAD.SCI.USA 2013REFN ESSN 1091-6490PMID 23630290DOI 10.1073/PNAS.1217730110 Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 4mzr TP53 crystal structure of a polypeptide p53 mutant bound to dna 2.9Å AUTH S.EMAMZADAH,L.TROPIA,I.VINCENTI,B.FALQUET,T.D.HALAZONETISTITL REVERSAL OF THE DNA-BINDING-INDUCED LOOP L1 CONFORMATIONALTITL 2 SWITCH IN AN ENGINEERED HUMAN P53 PROTEIN.REF J.MOL.BIOL. V. 426 936 2014REFN ISSN 0022-2836PMID 24374182DOI 10.1016/J.JMB.2013.12.020 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1e4j FCGR3B crystal structure of the soluble human fc-gamma receptor iii 2.5Å AUTH P.SONDERMANN,R.HUBER,V.OOSTHUIZEN,U.JACOBTITL THE 3.2-A CRYSTAL STRUCTURE OF THE HUMAN IGG1 FCTITL 2 FRAGMENT-FC GAMMARIII COMPLEX.REF NATURE V. 406 267 2000REFN ISSN 0028-0836PMID 10917521DOI 10.1038/35018508 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xze STAMBP structural basis for amsh-escrt-iii chmp3 interaction 1.75Å AUTH J.SOLOMONS,C.SABIN,E.POUDEVIGNE,Y.USAMI,D.L.HULSIK,AUTH 2 P.MACHEBOEUF,B.HARTLIEB,H.GOTTLINGER,W.WEISSENHORNTITL STRUCTURAL BASIS FOR ESCRT-III CHMP3 RECRUITMENT OF AMSH.REF STRUCTURE V. 19 1149 2011REFN ISSN 0969-2126PMID 21827950DOI 10.1016/J.STR.2011.05.011 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4b7l FLNB crystal structure of human filamin b actin binding domain with 1st filamin repeat 2.05Å AUTH G.M.SAWYER,A.J.SUTHERLAND-SMITHTITL CRYSTAL STRUCTURE OF THE FILAMIN N-TERMINAL REGION REVEALSTITL 2 A HINGE BETWEEN THE ACTIN BINDING AND FIRST REPEAT DOMAINSREF J.MOL.BIOL. V. 424 240 2012REFN ISSN 0022-2836PMID 23036857DOI 10.1016/J.JMB.2012.09.016 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2e9j FLNB solution structure of the 14th filamin domain from human filamin-b -1.0Å AUTH T.TOMIZAWA,S.KOSHIBA,S.WATANABE,T.HARADA,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE 14TH FILAMIN DOMAIN FROMTITL 2 HUMAN FILAMIN-BREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3puf RNASEH2A crystal structure of human rnase h2 complex 3.1Å AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3hfv FARS2 crystal structure of human mitochondrial phenylalanyl-trna synthetase complexed with m-tyrosine 2.6Å AUTH L.KLIPCAN,N.MOOR,N.KESSLER,M.G.SAFROTITL EUKARYOTIC CYTOSOLIC AND MITOCHONDRIALTITL 2 PHENYLALANYL-TRNA SYNTHETASES CATALYZE THE CHARGINGTITL 3 OF TRNA WITH THE META-TYROSINEREF PROC.NATL.ACAD.SCI.USA V. 106 11045 2009REFN ISSN 0027-8424PMID 19549855DOI 10.1073/PNAS.0905212106 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3nvq SEMA7A molecular mechanism of guidance cue recognition 2.4Å AUTH H.LIU,Z.S.JUO,A.H.SHIM,P.J.FOCIA,X.CHEN,K.C.GARCIA,X.HETITL STRUCTURAL BASIS OF SEMAPHORIN-PLEXIN RECOGNITION AND VIRALTITL 2 MIMICRY FROM SEMA7A AND A39R COMPLEXES WITH PLEXINC1.REF CELL(CAMBRIDGE,MASS.) V. 142 749 2010REFN ISSN 0092-8674PMID 20727575DOI 10.1016/J.CELL.2010.07.040 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants