General Structure Information
| PDB ID | 3puf |
| HGNC Gene Label(s) | RNASEH2A |
| Structure Name | crystal structure of human rnase h2 complex |
| Resolution | 3.1Å |
| Reference | AUTH M.FIGIEL,H.CHON,S.M.CERRITELLI,M.CYBULSKA,R.J.CROUCH,AUTH 2 M.NOWOTNYTITL THE STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF HUMANTITL 2 RNASE H2 COMPLEX REVEALS THE MOLECULAR BASIS FOR SUBSTRATETITL 3 RECOGNITION AND AICARDI-GOUTIERES SYNDROME DEFECTS.REF J.BIOL.CHEM. V. 286 10540 2011REFN ISSN 0021-9258PMID 21177858DOI 10.1074/JBC.M110.181974 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 270 |
| Number Of SNVs | 78 |
| Number Of Permutations | 24931 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.485 |
| p-value | 0.674 |
ClinVar
| Number Of Residues | 270 |
| Number Of SNVs | 7 |
| Number Of Permutations | 1896 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.333 |
| p-value | 0.022 |
COSMIC
| Number Of Residues | 270 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1222 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.2 |
| p-value | 0.759 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of ClinVar SNVs | 7 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.252 |
| p-value | 0.027 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.081 |
| p-value | 0.714 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
