Assessment of Structural Intolerance and Durability
General Structure Information 1n7d LDLR extracellular domain of the ldl receptor 3.7Å AUTH G.RUDENKO,L.HENRY,K.HENDERSON,K.ICHTCHENKO,M.S.BROWN,AUTH 2 J.L.GOLDSTEIN,J.DEISENHOFERTITL STRUCTURE OF THE LDL RECEPTOR EXTRACELLULAR DOMAIN ATTITL 2 ENDOSOMAL PHREF SCIENCE V. 298 2353 2002REFN ISSN 0036-8075PMID 12459547DOI 10.1126/SCIENCE.1078124 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gxm GBA crystal structure of acid-beta-glucosidase at ph 4.5, phosphate crystallization condition 2.2Å AUTH R.L.LIEBERMAN,J.A.DAQUINO,D.RINGE,G.A.PETSKOTITL EFFECTS OF PH AND IMINOSUGAR PHARMACOLOGICAL CHAPERONES ONTITL 2 LYSOSOMAL GLYCOSIDASE STRUCTURE AND STABILITY.REF BIOCHEMISTRY V. 48 4816 2009REFN ISSN 0006-2960PMID 19374450DOI 10.1021/BI9002265 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2knc ITGB3 platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1if4 CA2 carbonic anhydrase ii complexed with 4- fluorobenzenesulfonamide 1.93Å AUTH C.-Y.KIM,D.W.CHRISTIANSONTITL BINDING OF FLUORINE SUBSTITUTEDTITL 2 BENZENESULFONAMIDES TO CARBONIC ANHYDRASE IIREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3i6w CHEK2 structure and activation mechanism of the chk2 dna-damage checkpoint kinase 3.25Å AUTH Z.CAI,N.H.CHEHAB,N.P.PAVLETICHTITL STRUCTURE AND ACTIVATION MECHANISM OF THE CHK2 DNA DAMAGETITL 2 CHECKPOINT KINASE.REF MOL.CELL V. 35 818 2009REFN ISSN 1097-2765PMID 19782031DOI 10.1016/J.MOLCEL.2009.09.007 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3v83 TF the 2.1 angstrom crystal structure of diferric human transferrin 2.1Å AUTH N.NOINAJ,N.C.EASLEY,M.OKE,N.MIZUNO,J.GUMBART,E.BOURA,AUTH 2 A.N.STEERE,O.ZAK,P.AISEN,E.TAJKHORSHID,R.W.EVANS,AUTH 3 A.R.GORRINGE,A.B.MASON,A.C.STEVEN,S.K.BUCHANANTITL STRUCTURAL BASIS FOR IRON PIRACY BY PATHOGENIC NEISSERIA.REF NATURE V. 483 53 2012REFN ISSN 0028-0836PMID 22327295DOI 10.1038/NATURE10823 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2xrc CFI human complement factor i 2.69Å AUTH P.ROVERSI,S.JOHNSON,J.J.CAESAR,F.MCLEAN,K.J.LEATH,AUTH 2 S.A.TSIFTSOGLOU,B.P.MORGAN,C.L.HARRIS,R.B.SIM,S.M.LEATITL STRUCTURAL BASIS FOR COMPLEMENT FACTOR I CONTROL AND ITSTITL 2 DISEASE-ASSOCIATED SEQUENCE POLYMORPHISMS.REF PROC.NATL.ACAD.SCI.USA V. 108 12839 2011REFN ISSN 0027-8424PMID 21768352DOI 10.1073/PNAS.1102167108 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1ggu F13A1 human factor xiii with calcium bound in the ion site 2.1Å AUTH B.A.FOX,V.C.YEE,L.C.PEDERSEN,I.LE TRONG,P.D.BISHOP,AUTH 2 R.E.STENKAMP,D.C.TELLERTITL IDENTIFICATION OF THE CALCIUM BINDING SITE AND ATITL 2 NOVEL YTTERBIUM SITE IN BLOOD COAGULATION FACTORTITL 3 XIII BY X-RAY CRYSTALLOGRAPHY.REF J.BIOL.CHEM. V. 274 4917 1999REFN ISSN 0021-9258PMID 9988734DOI 10.1074/JBC.274.8.4917 Variant Set Distributions Ripley’s […]
General Structure Information 1xdm ALDOB structure of human aldolase b associated with hereditary fructose intolerance (a149p), at 291k 3.0Å AUTH A.D.MALAY,K.N.ALLEN,D.R.TOLANTITL STRUCTURE OF THE THERMOLABILE MUTANT ALDOLASE B,TITL 2 A149P: MOLECULAR BASIS OF HEREDITARY FRUCTOSETITL 3 INTOLERANCE.REF J.MOL.BIOL. V. 347 135 2005REFN ISSN 0022-2836PMID 15733923DOI 10.1016/J.JMB.2005.01.008 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2bxe ALB human serum albumin complexed with diflunisal 2.95Å AUTH J.GHUMAN,P.A.ZUNSZAIN,I.PETITPAS,A.A.BHATTACHARYA,AUTH 2 M.OTAGIRI,S.CURRYTITL STRUCTURAL BASIS OF THE DRUG-BINDING SPECIFICITYTITL 2 OF HUMAN SERUM ALBUMIN.REF J.MOL.BIOL. V. 353 38 2005REFN ISSN 0022-2836PMID 16169013DOI 10.1016/J.JMB.2005.07.075 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants