General Structure Information
| PDB ID | 3hfv |
| HGNC Gene Label(s) | FARS2 |
| Structure Name | crystal structure of human mitochondrial phenylalanyl-trna synthetase complexed with m-tyrosine |
| Resolution | 2.6Å |
| Reference | AUTH L.KLIPCAN,N.MOOR,N.KESSLER,M.G.SAFROTITL EUKARYOTIC CYTOSOLIC AND MITOCHONDRIALTITL 2 PHENYLALANYL-TRNA SYNTHETASES CATALYZE THE CHARGINGTITL 3 OF TRNA WITH THE META-TYROSINEREF PROC.NATL.ACAD.SCI.USA V. 106 11045 2009REFN ISSN 0027-8424PMID 19549855DOI 10.1073/PNAS.0905212106 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 405 |
| Number Of SNVs | 123 |
| Number Of Permutations | 33389 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.014 |
| p-value | 0.786 |
ClinVar
| Number Of Residues | 405 |
| Number Of SNVs | 10 |
| Number Of Permutations | 2532 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.333 |
| p-value | 0.409 |
COSMIC
| Number Of Residues | 405 |
| Number Of SNVs | 5 |
| Number Of Permutations | 291 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.2 |
| p-value | 0.044 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 123 |
| Number Of ClinVar SNVs | 10 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.098 |
| p-value | 0.392 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 123 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.311 |
| p-value | 0.024 |