Assessment of Structural Intolerance and Durability
General Structure Information 1sos SOD1 atomic structures of wild-type and thermostable mutant recombinant human cu, zn superoxide dismutase 2.5Å AUTH H.E.PARGE,R.A.HALLEWELL,J.A.TAINERTITL ATOMIC STRUCTURES OF WILD-TYPE AND THERMOSTABLETITL 2 MUTANT RECOMBINANT HUMAN CU,ZN SUPEROXIDETITL 3 DISMUTASE.REF PROC.NATL.ACAD.SCI.USA V. 89 6109 1992REFN ISSN 0027-8424PMID 1463506DOI 10.1073/PNAS.89.13.6109 Variant Set Distributions Mapped Variants
General Structure Information 2oct CSTB stefin b (cystatin b) tetramer 1.4Å AUTH S.JENKO KOKALJ,G.GUNCAR,I.STERN,G.MORGAN,S.RABZELJ,M.KENIG,AUTH 2 R.A.STANIFORTH,J.P.WALTHO,E.ZEROVNIK,D.TURKTITL ESSENTIAL ROLE OF PROLINE ISOMERIZATION IN STEFIN B TETRAMERTITL 2 FORMATION.REF J.MOL.BIOL. V. 366 1569 2007REFN ISSN 0022-2836PMID 17217964DOI 10.1016/J.JMB.2006.12.025 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2nz2 ASS1 crystal structure of human argininosuccinate synthase in complex with aspartate and citrulline 2.4Å AUTH T.KARLBERG,R.COLLINS,S.VAN DEN BERG,A.FLORES,M.HAMMARSTROM,AUTH 2 M.HOGBOM,L.HOLMBERG SCHIAVONE,J.UPPENBERGTITL STRUCTURE OF HUMAN ARGININOSUCCINATE SYNTHETASE.REF ACTA CRYSTALLOGR.,SECT.D V. 64 279 2008REFN ISSN 0907-4449PMID 18323623DOI 10.1107/S0907444907067455 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f83 F11 crystal structure at 2.9 angstroms resolution of human plasma coagulation factor xi zymogen 2.87Å AUTH E.PAPAGRIGORIOU,P.A.MCEWAN,P.N.WALSH,J.EMSLEYTITL CRYSTAL STRUCTURE OF THE FACTOR XI ZYMOGEN REVEALS A PATHWAYTITL 2 FOR TRANSACTIVATION.REF NAT.STRUCT.MOL.BIOL. V. 13 557 2006REFN ISSN 1545-9993PMID 16699514DOI 10.1038/NSMB1095 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3ruk CYP17A1 human cytochrome p450 cyp17a1 in complex with abiraterone 2.6Å AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2jq3 APOC3 structure and dynamics of human apolipoprotein c-iii -1.0Å AUTH C.S.GANGABADAGE,J.ZDUNEK,M.TESSARI,S.NILSSON,AUTH 2 G.OLIVECRONA,S.S.WIJMENGATITL STRUCTURE AND DYNAMICS OF HUMAN APOLIPOPROTEIN CIIIREF J.BIOL.CHEM. V. 283 17416 2008REFN ISSN 0021-9258PMID 18408013DOI 10.1074/JBC.M800756200 Variant Set Distributions Mapped Variants
General Structure Information 2oay SERPING1 crystal structure of latent human c1-inhibitor 2.35Å AUTH L.BEINROHR,V.HARMAT,J.DOBO,Z.LORINCZ,P.GAL,P.ZAVODSZKYTITL C1 INHIBITOR SERPIN DOMAIN STRUCTURE REVEALS THE LIKELYTITL 2 MECHANISM OF HEPARIN POTENTIATION AND CONFORMATIONAL DISEASEREF J.BIOL.CHEM. V. 282 21100 2007REFN ISSN 0021-9258PMID 17488724DOI 10.1074/JBC.M700841200 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2wpl F9 factor ixa superactive triple mutant, edta-soaked 1.82Å AUTH T.ZOGG,H.BRANDSTETTERTITL STRUCTURAL BASIS OF THE COFACTOR- ANDTITL 2 SUBSTRATE-ASSISTED ACTIVATION OF HUMAN COAGULATIONTITL 3 FACTOR IXAREF STRUCTURE V. 17 1669 2009REFN ISSN 0969-2126PMID 20004170DOI 10.1016/J.STR.2009.10.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3th7 ARG1 crystal structure of unliganded co2+2-hai (ph 7.0) 2.1Å AUTH E.L.DANTONIO,D.W.CHRISTIANSONTITL CRYSTAL STRUCTURES OF COMPLEXES WITH COBALT-RECONSTITUTEDTITL 2 HUMAN ARGINASE I.REF BIOCHEMISTRY V. 50 8018 2011REFN ISSN 0006-2960PMID 21870783DOI 10.1021/BI201101T Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1gbn OAT human ornithine aminotransferase complexed with the neurotoxin gabaculine 2.3Å AUTH S.A.SHAH,B.W.SHEN,A.T.BRUNGERTITL HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH L-CANALINETITL 2 AND GABACULINE: STRUCTURAL BASIS FOR SUBSTRATE RECOGNITION.REF STRUCTURE V. 5 1067 1997REFN ISSN 0969-2126PMID 9309222DOI 10.1016/S0969-2126(97)00258-X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants