General Structure Information
| PDB ID | 3ruk |
| HGNC Gene Label(s) | CYP17A1 |
| Structure Name | human cytochrome p450 cyp17a1 in complex with abiraterone |
| Resolution | 2.6Å |
| Reference | AUTH N.M.DEVORE,E.E.SCOTTTITL STRUCTURES OF CYTOCHROME P450 17A1 WITH PROSTATE CANCERTITL 2 DRUGS ABIRATERONE AND TOK-001.REF NATURE V. 482 116 2012REFN ISSN 0028-0836PMID 22266943DOI 10.1038/NATURE10743 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 472 |
| Number Of SNVs | 110 |
| Number Of Permutations | 65446 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.019 |
| p-value | 0.937 |
ClinVar
| Number Of Residues | 472 |
| Number Of SNVs | 16 |
| Number Of Permutations | 15716 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.192 |
| p-value | 0.016 |
COSMIC
| Number Of Residues | 472 |
| Number Of SNVs | 3 |
| Number Of Permutations | 18 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.667 |
| p-value | 0.233 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 110 |
| Number Of ClinVar SNVs | 16 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.133 |
| p-value | 0.016 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 110 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 22.0 |
| K Statistic | 0.727 |
| p-value | 0.208 |