General Structure Information
| PDB ID | 2oay |
| HGNC Gene Label(s) | SERPING1 |
| Structure Name | crystal structure of latent human c1-inhibitor |
| Resolution | 2.35Å |
| Reference | AUTH L.BEINROHR,V.HARMAT,J.DOBO,Z.LORINCZ,P.GAL,P.ZAVODSZKYTITL C1 INHIBITOR SERPIN DOMAIN STRUCTURE REVEALS THE LIKELYTITL 2 MECHANISM OF HEPARIN POTENTIATION AND CONFORMATIONAL DISEASEREF J.BIOL.CHEM. V. 282 21100 2007REFN ISSN 0021-9258PMID 17488724DOI 10.1074/JBC.M700841200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 368 |
| Number Of SNVs | 80 |
| Number Of Permutations | 13777 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.087 |
| p-value | 0.205 |
ClinVar
| Number Of Residues | 368 |
| Number Of SNVs | 4 |
| Number Of Permutations | 396 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.167 |
| p-value | 0.07 |
COSMIC
| Number Of Residues | 368 |
| Number Of SNVs | 5 |
| Number Of Permutations | 191 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.1 |
| p-value | 0.863 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 80 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.162 |
| p-value | 0.052 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 80 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 30.0 |
| K Statistic | -0.276 |
| p-value | 1.0 |