Assessment of Structural Intolerance and Durability
General Structure Information 3f6u PROC crystal structure of human activated protein c (apc) complexed with ppack 2.8Å AUTH A.E.SCHMIDT,K.PADMANABHAN,M.C.UNDERWOOD,W.BODE,T.MATHER,AUTH 2 S.P.BAJAJTITL THERMODYNAMIC LINKAGE BETWEEN THE S1 SITE, THE NA+ SITE, ANDTITL 2 THE CA2+ SITE IN THE PROTEASE DOMAIN OF HUMAN ACTIVATEDTITL 3 PROTEIN C (APC).REF J.BIOL.CHEM. V. 277 28987 2002REFN ISSN 0021-9258PMID 12029084DOI 10.1074/JBC.M201892200 […]
General Structure Information 2xn5 SERPINA7 crystal structure of thyroxine-binding globulin complexed with furosemide 1.7Å AUTH X.QI,F.LOISEAU,W.L.CHAN,Y.YAN,Z.WEI,L.G.MILROY,AUTH 2 R.M.MYERS,S.V.LEY,R.J.READ,R.W.CARRELL,A.ZHOUTITL ALLOSTERIC MODULATION OF HORMONE RELEASE FROMTITL 2 THYROXINE AND CORTICOSTEROID BINDING-GLOBULINS.REF J.BIOL.CHEM. V. 286 16163 2011REFN ISSN 0021-9258PMID 21325280DOI 10.1074/JBC.M110.171082 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 4lpk KRAS crystal structure of k-ras wt, gdp-bound 1.5Å AUTH J.M.OSTREM,U.PETERS,M.L.SOS,J.A.WELLS,K.M.SHOKATTITL K-RAS(G12C) INHIBITORS ALLOSTERICALLY CONTROL GTP AFFINITYTITL 2 AND EFFECTOR INTERACTIONS.REF NATURE V. 503 548 2013REFN ISSN 0028-0836PMID 24256730DOI 10.1038/NATURE12796 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3nxp F2 crystal structure of human prethrombin-1 2.2Å AUTH Z.CHEN,L.A.PELC,E.DI CERATITL CRYSTAL STRUCTURE OF PRETHROMBIN-1.REF PROC.NATL.ACAD.SCI.USA V. 107 19278 2010REFN ISSN 0027-8424PMID 20974933DOI 10.1073/PNAS.1010262107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3gt8 EGFR crystal structure of the inactive egfr kinase domain in complex with amp-pnp 2.96Å AUTH N.JURA,N.F.ENDRES,K.ENGEL,S.DEINDL,R.DAS,AUTH 2 M.H.LAMERS,D.E.WEMMER,X.ZHANG,J.KURIYANTITL MECHANISM FOR ACTIVATION OF THE EGF RECEPTORTITL 2 CATALYTIC DOMAIN BY THE JUXTAMEMBRANE SEGMENT.REF CELL(CAMBRIDGE,MASS.) V. 137 1293 2009REFN ISSN 0092-8674PMID 19563760DOI 10.1016/J.CELL.2009.04.025 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3zqk VWF von willebrand factor a2 domain with calcium 1.7Å AUTH A.J.JAKOBI,A.MASHAGHI,S.J.TANS,E.G.HUIZINGATITL CALCIUM MODULATES FORCE SENSING BY THE VON WILLEBRANDTITL 2 FACTOR A2 DOMAIN.REF NAT.COMMUN. V. 2 385 2011REFN ISSN 2041-1723PMID 21750539DOI 10.1038/NCOMMS1385 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1dmw PAH crystal structure of double truncated human phenylalanine hydroxylase with bound 7,8-dihydro-l-biopterin 2.0Å AUTH H.ERLANDSEN,E.BJORGO,T.FLATMARK,R.C.STEVENSTITL CRYSTAL STRUCTURE AND SITE-SPECIFIC MUTAGENESIS OFTITL 2 PTERIN-BOUND HUMAN PHENYLALANINE HYDROXYLASE.REF BIOCHEMISTRY V. 39 2208 2000REFN ISSN 0006-2960PMID 10694386DOI 10.1021/BI992531+ Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3rcd ERBB2 her2 kinase domain complexed with tak-285 3.21Å AUTH T.ISHIKAWA,M.SETO,H.BANNO,Y.KAWAKITA,M.OORUI,T.TANIGUCHI,AUTH 2 Y.OHTA,T.TAMURA,A.NAKAYAMA,H.MIKI,H.KAMIGUCHI,T.TANAKA,AUTH 3 N.HABUKA,S.SOGABE,J.YANO,K.AERTGEERTS,K.KAMIYAMATITL DESIGN AND SYNTHESIS OF NOVEL HUMAN EPIDERMAL GROWTH FACTORTITL 2 RECEPTOR 2 (HER2)/EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)TITL 3 DUAL INHIBITORS BEARING A PYRROLO[3,2-D]PYRIMIDINE SCAFFOLD.REF J.MED.CHEM. V. 54 8030 2011REFN ISSN 0022-2623PMID 22003817DOI 10.1021/JM2008634 Variant Set Distributions Ripley’s […]
General Structure Information 2y3i PGK1 the structure of the fully closed conformation of human pgk in complex with l-adp, 3pg and the tsa aluminium tetrafluoride 2.9Å AUTH P.LALLEMAND,L.CHALOIN,B.ROY,T.BARMAN,M.W.BOWLER,C.LIONNETITL INTERACTION OF HUMAN 3-PHOSPHOGLYCERATE KINASE WITH ITS TWOTITL 2 SUBSTRATES: IS SUBSTRATE ANTAGONISM A KINETIC ADVANTAGE?REF J.MOL.BIOL. V. 409 742 2011REFN ISSN 0022-2836PMID 21549713DOI 10.1016/J.JMB.2011.04.048 Variant Set […]