Assessment of Structural Intolerance and Durability
General Structure Information 1m6i AIFM1 crystal structure of apoptosis inducing factor (aif) 1.8Å AUTH H.YE,C.CANDE,N.C.STEPHANOU,S.JIANG,S.GURBUXANI,AUTH 2 N.LAROCHETTE,E.DAUGAS,C.GARRIDO,G.KROEMER,H.WUTITL DNA BINDING IS REQUIRED FOR THE APOPTOGENIC ACTIONTITL 2 OF APOPTOSIS INDUCING FACTOR.REF NAT.STRUCT.BIOL. V. 9 680 2002REFN ISSN 1072-8368PMID 12198487DOI 10.1038/NSB836 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2j5w CP ceruloplasmin revisited: structural and functional roles of various metal cation binding sites 2.8Å AUTH I.BENTO,C.PEIXOTO,V.N.ZAITSEV,P.F.LINDLEYTITL CERULOPLASMIN REVISITED: STRUCTURAL AND FUNCTIONALTITL 2 ROLES OF VARIOUS METAL CATION-BINDING SITES.REF ACTA CRYSTALLOGR.,SECT.D V. 63 240 2007REFN ISSN 0907-4449PMID 17242517DOI 10.1107/S090744490604947X Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 1brp RBP4 crystal structure of the trigonal form of human plasma retinol-binding protein at 2.5 angstroms resolution 2.5Å AUTH G.ZANOTTI,S.OTTONELLO,R.BERNI,H.L.MONACOTITL CRYSTAL STRUCTURE OF THE TRIGONAL FORM OF HUMANTITL 2 PLASMA RETINOL-BINDING PROTEIN AT 2.5 A RESOLUTION.REF J.MOL.BIOL. V. 230 613 1993REFN ISSN 0022-2836PMID 8464067DOI 10.1006/JMBI.1993.1173 Variant Set Distributions Mapped Variants
General Structure Information 4der TTR crystal structure of the wild type ttr binding apigenin (ttrwt:api) 1.9Å AUTH D.B.TRIVELLA,C.V.DOS REIS,L.M.LIMA,D.FOGUEL,I.POLIKARPOVTITL FLAVONOID INTERACTIONS WITH HUMAN TRANSTHYRETIN: COMBINEDTITL 2 STRUCTURAL AND THERMODYNAMIC ANALYSIS.REF J.STRUCT.BIOL. V. 180 143 2012REFN ISSN 1047-8477PMID 22842046DOI 10.1016/J.JSB.2012.07.008 Variant Set Distributions Mapped Variants
General Structure Information 2fo0 ABL1 organization of the sh3-sh2 unit in active and inactive forms of the c-abl tyrosine kinase 2.27Å AUTH B.NAGAR,O.HANTSCHEL,M.SEELIGER,J.M.DAVIES,W.I.WEIS,AUTH 2 G.SUPERTI-FURGA,J.KURIYANTITL ORGANIZATION OF THE SH3-SH2 UNIT IN ACTIVE AND INACTIVETITL 2 FORMS OF THE C-ABL TYROSINE KINASE.REF MOL.CELL V. 21 787 2006REFN ISSN 1097-2765PMID 16543148DOI 10.1016/J.MOLCEL.2006.01.035 Variant Set Distributions Ripley’s K […]
General Structure Information 4f0i NTRK1 crystal structure of apo trka 2.3Å AUTH T.BERTRAND,M.KOTHE,J.LIU,A.DUPUY,A.RAK,P.F.BERNE,S.DAVIS,AUTH 2 T.GLADYSHEVA,C.VALTRE,J.Y.CRENNE,M.MATHIEUTITL THE CRYSTAL STRUCTURES OF TRKA AND TRKB SUGGEST KEY REGIONSTITL 2 FOR ACHIEVING SELECTIVE INHIBITION.REF J.MOL.BIOL. V. 423 439 2012REFN ISSN 0022-2836PMID 22902478DOI 10.1016/J.JMB.2012.08.002 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 1c9y OTC human ornithine transcarbamylase: crystallographic insights into substrate recognition and catalytic mechanism 1.9Å AUTH D.SHI,H.MORIZONO,M.AOYAGI,M.TUCHMAN,N.M.ALLEWELLTITL CRYSTAL STRUCTURE OF HUMAN ORNITHINE TRANSCARBAMYLASETITL 2 COMPLEXED WITH CARBAMOYL PHOSPHATE AND L-NORVALINE AT 1.9 ATITL 3 RESOLUTION.REF PROTEINS V. 39 271 2000REFN ISSN 0887-3585PMID 10813810DOI 10.1002/(SICI)1097-0134(20000601)39:43.3.CO;2-5 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 1psi SERPINA1 intact recombined alpha1-antitrypsin mutant phe 51 to leu 2.92Å AUTH P.R.ELLIOTT,D.A.LOMAS,R.W.CARRELL,J.P.ABRAHAMSTITL INHIBITORY CONFORMATION OF THE REACTIVE LOOP OFTITL 2 ALPHA 1-ANTITRYPSIN.REF NAT.STRUCT.BIOL. V. 3 676 1996REFN ISSN 1072-8368PMID 8756325DOI 10.1038/NSB0896-676 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3k71 ITGB2 structure of integrin alphax beta2 ectodomain 3.95Å AUTH C.XIE,J.ZHU,X.CHEN,L.MI,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF AN INTEGRIN WITH AN ALPHAI DOMAIN,TITL 2 COMPLEMENT RECEPTOR TYPE 4.REF EMBO J. V. 29 666 2010REFN ISSN 0261-4189PMID 20033057DOI 10.1038/EMBOJ.2009.367 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ghg FGG crystal structure of human fibrinogen 2.9Å AUTH J.M.KOLLMAN,L.PANDI,M.R.SAWAYA,M.RILEY,R.F.DOOLITTLETITL CRYSTAL STRUCTURE OF HUMAN FIBRINOGEN.REF BIOCHEMISTRY V. 48 3877 2009REFN ISSN 0006-2960PMID 19296670DOI 10.1021/BI802205G Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants