Assessment of Structural Intolerance and Durability
General Structure Information 2r2p EPHA5 kinase domain of human ephrin type-a receptor 5 (epha5) 2.4Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 5TITL 2 (EPHA5).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2f5y RGS3 crystal structure of the pdz domain from human rgs-3 2.39Å AUTH E.UGOCHUKWU,G.BERRIDGE,C.JOHANSSON,C.SMEE,P.SAVITSKY,AUTH 2 N.BURGESS,S.COLEBROOK,X.YANG,J.ELKINS,D.DOYLE,A.TURNBULL,AUTH 3 E.PAPAGRIGORIOU,J.DEBRECZENI,G.BUNKOCZI,F.GORREC,AUTH 4 F.VON DELFT,C.ARROWSMITH,M.SUNDSTROM,J.WEIGELT,A.EDWARDSTITL CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2gfu MSH6 nmr solution structure of the pwwp domain of mismatch repair protein hmsh6 -1.0Å AUTH C.LAGURI,I.DUBAND-GOULET,N.FRIEDRICH,M.AXT,P.BELIN,AUTH 2 B.GILQUIN,S.ZINN-JUSTIN,J.COUPRIETITL THE PWWP DOMAIN OF MISMATCH REPAIR PROTEIN HMSH6TITL 2 IS INVOLVED IN DOUBLE STRANDED AND SINGLE STRANDEDTITL 3 DNA BINDINGREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2o8d MSH6 human mutsalpha (msh2/msh6) bound to adp and a g du mispair 3.0Å AUTH J.J.WARREN,T.J.POHLHAUS,A.CHANGELA,R.R.IYER,P.L.MODRICH,AUTH 2 L.S.BEESETITL STRUCTURE OF THE HUMAN MUTSALPHA DNA LESION RECOGNITIONTITL 2 COMPLEX.REF MOL.CELL V. 26 579 2007REFN ISSN 1097-2765PMID 17531815DOI 10.1016/J.MOLCEL.2007.04.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1rv6 PGF crystal structure of plgf in complex with domain 2 of vegfr1 2.45Å AUTH H.W.CHRISTINGER,G.FUH,A.M.DE VOS,C.WIESMANNTITL THE CRYSTAL STRUCTURE OF PLACENTAL GROWTH FACTOR IN COMPLEXTITL 2 WITH DOMAIN 2 OF VASCULAR ENDOTHELIAL GROWTH FACTORTITL 3 RECEPTOR-1.REF J.BIOL.CHEM. V. 279 10382 2004REFN ISSN 0021-9258PMID 14684734DOI 10.1074/JBC.M313237200 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 3nr9 CLK2 structure of human cdc2-like kinase 2 (clk2) 2.89Å AUTH A.CHAIKUAD,P.SAVITSKY,T.KROJER,J.R.C.MUNIZ,AUTH 2 P.FILIPPAKOPOULOS,P.RELLOS,T.KEATES,O.FEDOROV,A.C.W.PIKE,AUTH 3 J.ESWARAN,G.BERRIDGE,C.PHILLIPS,Y.ZHANG,F.VON DELFT,AUTH 4 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,C.BOUNTRA,S.KNAPP,AUTH 5 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL STRUCTURE OF HUMAN CDC2-LIKE KINASE 2 (CLK2)REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4ick NUDT2 crystal structure of human ap4a hydrolase e58a mutant 2.1Å AUTH H.GE,X.CHEN,W.YANG,L.NIU,M.TENGTITL CRYSTAL STRUCTURE OF WILD-TYPE AND MUTANT HUMAN AP4ATITL 2 HYDROLASE.REF BIOCHEM.BIOPHYS.RES.COMMUN. V. 432 16 2013REFN ISSN 0006-291XPMID 23384440DOI 10.1016/J.BBRC.2013.01.095 Variant Set Distributions Mapped Variants
General Structure Information 3gub DAPK1 crystal structure of dapkl93g complexed with n6-(2- phenylethyl)adenosine 1.71Å AUTH L.K.MCNAMARA,J.S.SCHAVOCKY,D.M.WATTERSON,AUTH 2 J.S.BRUNZELLETITL CRYSTAL STRUCTURES OF THE DAPK GATEKEEPER MUTANTTITL 2 COMPLEXED WITH N6-MODIFIED ADENOSINE ANALOGS.REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bcj CDK9 structure of cdk9 in complex with cyclin t and a 2-amino-4- heteroaryl-pyrimidine inhibitor 3.16Å AUTH A.J.HOLE,S.BAUMLI,H.SHAO,S.SHI,C.PEPPER,P.M.FISCHER,S.WANG,AUTH 2 J.A.ENDICOTT,M.E.M.NOBLETITL COMPARATIVE STRUCTURAL AND FUNCTIONAL STUDIES OFTITL 2 4-(THIAZOL- 5-YL)-2-(PHENYLAMINO)PYRIMIDINE-5-CARBONITRILETITL 3 CDK9 INHIBITORS SUGGEST THE BASIS FOR ISOTYPE SELECTIVITY.REF J.MED.CHEM. V. 56 660 2013REFN ISSN 0022-2623PMID 23252711DOI 10.1021/JM301495V Variant Set Distributions Mapped Variants
General Structure Information 2yn8 EPHB4 ephb4 kinase domain inhibitor complex 2.11Å AUTH R.C.OVERMAN,I.GREEN,C.M.TRUMAN,J.A.READ,K.J.EMBREY,AUTH 2 M.S.B.MCALISTER,T.K.ATTWOODTITL STABILITY AND SOLUBILITY ENGINEERING OF THE EPHB4 TYROSINETITL 2 KINASE CATALYTIC DOMAIN USING A RATIONALLY DESIGNEDTITL 3 SYNTHETIC LIBRARY.REF PROTEIN ENG.DES.SEL. V. 26 695 2013REFN ISSN 1741-0126PMID 23840071DOI 10.1093/PROTEIN/GZT032 Variant Set Distributions Mapped Variants