Assessment of Structural Intolerance and Durability
General Structure Information 1ua2 CDK7 crystal structure of human cdk7 3.02Å AUTH G.LOLLI,E.D.LOWE,N.R.BROWN,L.N.JOHNSONTITL THE CRYSTAL STRUCTURE OF HUMAN CDK7 AND ITS PROTEINTITL 2 RECOGNITION PROPERTIESREF STRUCTURE V. 12 2067 2004REFN ISSN 0969-2126PMID 15530371DOI 10.1016/J.STR.2004.08.013 Variant Set Distributions Mapped Variants
General Structure Information 3w1g LIG4 crystal structure of human dna ligase iv-artemis complex (native) 2.55Å AUTH T.OCHI,X.GU,T.L.BLUNDELLTITL STRUCTURE OF THE CATALYTIC REGION OF DNA LIGASE IV INTITL 2 COMPLEX WITH AN ARTEMIS FRAGMENT SHEDS LIGHT ONTITL 3 DOUBLE-STRAND BREAK REPAIRREF STRUCTURE V. 21 672 2013REFN ISSN 0969-2126PMID 23523427DOI 10.1016/J.STR.2013.02.014 Variant Set Distributions Ripley’s K Analysis […]
General Structure Information 2jri ATXN3 solution structure of the josephin domain of ataxin-3 in complex with ubiquitin molecule. -1.0Å AUTH G.NICASTRO,R.MENON,L.MASINO,A.PASTORETITL UNDERSTANDING THE PLASTICITY OF THETITL 2 UBIQUITIN-PROTEIN RECOGNITION CODE: THE JOSEPHINTITL 3 DOMAIN OF ATAXIN-3 IS A DIUBIQUITIN BINDING MOTIFREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2e7h EPHB4 solution structure of the second fn3 domain from human ephrin type-b receptor 4 -1.0Å AUTH X.R.QIN,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE SECOND FN3 DOMAIN FROMTITL 2 HUMAN EPHRIN TYPE-B RECEPTOR 4REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3enm MAP2K6 the structure of the map2k mek6 reveals an autoinhibitory dimer 2.35Å AUTH X.MIN,R.AKELLA,H.HE,J.M.HUMPHREYS,S.E.TSUTAKAWA,S.J.LEE,AUTH 2 J.A.TAINER,M.H.COBB,E.J.GOLDSMITHTITL THE STRUCTURE OF THE MAP2K MEK6 REVEALS AN AUTOINHIBITORYTITL 2 DIMERREF STRUCTURE V. 17 96 2009REFN ISSN 0969-2126PMID 19141286DOI 10.1016/J.STR.2008.11.007 Variant Set Distributions Mapped Variants
General Structure Information 3fbk RGS3 crystal structure of the c2 domain of the human regulator of g-protein signaling 3 isoform 6 (rgp3), northeast structural genomics consortium target hr5550a 2.0Å AUTH F.FOROUHAR,S.LEW,J.SEETHARAMAN,L.MAO,R.XIAO,AUTH 2 C.CICCOSANTI,E.L.FOOTE,R.SHASTRY,J.K.EVERETT,AUTH 3 R.NAIR,T.B.ACTON,B.ROST,G.T.MONTELIONE,J.F.HUNT,AUTH 4 L.TONGTITL CRYSTAL STRUCTURE OF THE C2 DOMAIN OF THE HUMANTITL 2 REGULATOR OF G-PROTEIN SIGNALING 3 ISOFORM 6TITL 3 […]
General Structure Information 3v6o LEPR leptin receptor-antibody complex 1.95Å AUTH B.CARPENTER,G.R.HEMSWORTH,Z.WU,M.MAAMRA,C.J.STRASBURGER,AUTH 2 R.J.ROSS,P.J.ARTYMIUKTITL STRUCTURE OF THE HUMAN OBESITY RECEPTOR LEPTIN-BINDINGTITL 2 DOMAIN REVEALS THE MECHANISM OF LEPTIN ANTAGONISM BY ATITL 3 MONOCLONAL ANTIBODY.REF STRUCTURE V. 20 487 2012REFN ISSN 0969-2126PMID 22405007DOI 10.1016/J.STR.2012.01.019 Variant Set Distributions Mapped Variants
General Structure Information 3an2 CENPA the structure of the centromeric nucleosome containing cenp-a 3.6Å AUTH H.TACHIWANA,W.KAGAWA,T.SHIGA,A.OSAKABE,Y.MIYA,K.SAITO,AUTH 2 Y.HAYASHI-TAKANAKA,T.ODA,M.SATO,S.-Y.PARK,H.KIMURA,AUTH 3 H.KURUMIZAKATITL CRYSTAL STRUCTURE OF THE HUMAN CENTROMERIC NUCLEOSOMETITL 2 CONTAINING CENP-AREF NATURE V. 476 232 2011REFN ISSN 0028-0836PMID 21743476DOI 10.1038/NATURE10258 Variant Set Distributions Mapped Variants
General Structure Information 3p0u NR2C2 crystal structure of the ligand binding domain of human testicular receptor 4 3.0Å AUTH X.E.ZHOU,K.M.SUINO-POWELL,Y.XU,C.W.CHAN,O.TANABE,S.W.KRUSE,AUTH 2 R.REYNOLDS,J.D.ENGEL,H.E.XUTITL THE ORPHAN NUCLEAR RECEPTOR TR4 IS A VITAMIN A-ACTIVATEDTITL 2 NUCLEAR RECEPTOR.REF J.BIOL.CHEM. V. 286 2877 2011REFN ISSN 0021-9258PMID 21068381DOI 10.1074/JBC.M110.168740 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 1cm8 MAPK12 phosphorylated map kinase p38-gamma 2.4Å AUTH S.BELLON,M.J.FITZGIBBON,T.FOX,H.M.HSIAO,K.P.WILSONTITL THE STRUCTURE OF PHOSPHORYLATED P38GAMMA ISTITL 2 MONOMERIC AND REVEALS A CONSERVED ACTIVATION-LOOPTITL 3 CONFORMATION.REF STRUCTURE FOLD.DES. V. 7 1057 1999REFN ISSN 0969-2126PMID 10508788DOI 10.1016/S0969-2126(99)80173-7 Variant Set Distributions Mapped Variants