Assessment of Structural Intolerance and Durability
General Structure Information 2ebv NUP153 solution structure of the third zf-ranbp domain from human nuclear pore complex protein nup153 -1.0Å AUTH H.P.ZHANG,F.HAYASHI,S.YOKOYAMATITL SOLUTION STRUCTURE OF THE THIRD ZF-RANBP DOMAINTITL 2 FROM HUMAN NUCLEAR PORE COMPLEX PROTEIN NUP153REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2g2b AIF1 nmr structure of the human allograft inflammatory factor 1 -1.0Å AUTH J.SONG,R.C.TYLER,C.L.NEWMAN,D.VINAROV,J.L.MARKLEYTITL NMR STRUCTURE OF THE HUMAN ALLOGRAFT INFLAMMATORYTITL 2 FACTOR 1REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3ii6 LIG4 structure of human xrcc4 in complex with the tandem brct domains of dna ligaseiv. 2.4Å AUTH P.Y.WU,P.FRIT,S.MEESALA,S.DAUVILLIER,M.MODESTI,AUTH 2 S.N.ANDRES,Y.HUANG,J.SEKIGUCHI,P.CALSOU,B.SALLES,AUTH 3 M.S.JUNOPTITL STRUCTURAL AND FUNCTIONAL INTERACTION BETWEEN THETITL 2 HUMAN DNA REPAIR PROTEINS DNA LIGASE IV AND XRCC4REF MOL.CELL.BIOL. V. 11 3163 2009REFN ISSN 0270-7306PMID 19332554 Variant Set Distributions Ripley’s K […]
General Structure Information 1yr5 DAPK1 1.7-a structure of calmodulin bound to a peptide from dap kinase 1.7Å AUTH P.KURSULA,J.VAHOKOSKI,M.WILMANNSTITL RECOGNITION OF HUMAN DEATH-ASSOCIATED PROTEIN KINASES BYTITL 2 CALMODULINREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1xa6 CHN2 crystal structure of the human beta2-chimaerin 3.2Å AUTH B.CANAGARAJAH,F.C.LESKOW,J.Y.HO,H.MISCHAK,AUTH 2 L.F.SAIDI,M.G.KAZANIETZ,J.H.HURLEYTITL STRUCTURAL MECHANISM FOR LIPID ACTIVATION OF THETITL 2 RAC-SPECIFIC GAP, BETA2-CHIMAERIN.REF CELL(CAMBRIDGE,MASS.) V. 119 407 2004REFN ISSN 0092-8674PMID 15507211DOI 10.1016/J.CELL.2004.10.012 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2gs3 GPX4 crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(gpx4) 1.9Å AUTH C.JOHANSSON,K.L.KAVANAGH,A.ROJKOVA,O.GILEADI,F.VON DELFT,AUTH 2 C.ARROWSMITH,J.WEIGELT,M.SUNDSTROM,A.EDWARDS,U.OPPERMANN,AUTH 3 STRUCTURAL GENOMICS CONSORTIUM (SGC)TITL CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OFTITL 2 HUMAN GLUTATHIONE PEROXIDASE 4(GPX4)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 2ger PYCR1 crystal structure and oxidative mechanism of human pyrroline-5- carboxylate reductase 3.1Å AUTH Z.MENG,Z.LOU,Z.LIU,M.LI,X.ZHAO,M.BARTLAM,Z.RAOTITL CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE REDUCTASEREF J.MOL.BIOL. V. 359 1364 2006REFN ISSN 0022-2836PMID 16730026DOI 10.1016/J.JMB.2006.04.053 Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4bkt VHL von hippel lindau protein:elonginb:elonginc complex, in complex with (2s,4r)-n-methyl-1-[2-(3-methyl-1,2-oxazol-5-yl)ethanoyl]-4- oxidanyl-pyrrolidine-2-carboxamide 2.35Å AUTH D.M.DIAS,I.VAN MOLLE,M.G.J.BAUD,C.GALDEANO,C.F.G.C.GERALDES,AUTH 2 A.CIULLITITL IS NMR FRAGMENT SCREENING FINE-TUNED TO ASSESS DRUGGABILITYTITL 2 OF PROTEIN-PROTEIN INTERACTIONS?REF ACS MED.CHEM.LETT. V. 5 23 2014REFN ISSN 1948-5875PMID 24436777DOI 10.1021/ML400296C Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3wef FDFT1 crystal structure of the human squalene synthase in complex with farnesyl thiopyrophosphate 2.35Å AUTH C.I.LIU,W.Y.JENG,W.J.CHANG,M.F.SHIH,T.P.KO,A.H.J.WANGTITL STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM OF HUMANTITL 2 SQUALENE SYNTHASEREF ACTA CRYSTALLOGR.,SECT.D V. 70 231 2014REFN ISSN 0907-4449DOI 10.1107/S1399004713026230 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4k5y CRHR1 crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 2.98Å AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]