General Structure Information
| PDB ID | 4k5y |
| HGNC Gene Label(s) | CRHR1 |
| Structure Name | crystal structure of human corticotropin-releasing factor receptor 1 (crf1r) in complex with the antagonist cp-376395 |
| Resolution | 2.98Å |
| Reference | AUTH K.HOLLENSTEIN,J.KEAN,A.BORTOLATO,R.K.CHENG,A.S.DORE,AUTH 2 A.JAZAYERI,R.M.COOKE,M.WEIR,F.H.MARSHALLTITL STRUCTURE OF CLASS B GPCR CORTICOTROPIN-RELEASING FACTORTITL 2 RECEPTOR 1.REF NATURE V. 499 438 2013REFN ISSN 0028-0836PMID 23863939DOI 10.1038/NATURE12357 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 248 |
| Number Of SNVs | 59 |
| Number Of Permutations | 10407 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.259 |
| p-value | 0.009 |
COSMIC
| Number Of Residues | 248 |
| Number Of SNVs | 7 |
| Number Of Permutations | 537 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.048 |
| p-value | 0.635 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.12 |
| p-value | 0.745 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
