General Structure Information
| PDB ID | 2gfu |
| HGNC Gene Label(s) | MSH6 |
| Structure Name | nmr solution structure of the pwwp domain of mismatch repair protein hmsh6 |
| Resolution | -1.0Å |
| Reference | AUTH C.LAGURI,I.DUBAND-GOULET,N.FRIEDRICH,M.AXT,P.BELIN,AUTH 2 B.GILQUIN,S.ZINN-JUSTIN,J.COUPRIETITL THE PWWP DOMAIN OF MISMATCH REPAIR PROTEIN HMSH6TITL 2 IS INVOLVED IN DOUBLE STRANDED AND SINGLE STRANDEDTITL 3 DNA BINDINGREF TO BE PUBLISHEDREFN |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 134 |
| Number Of SNVs | 24 |
| Number Of Permutations | 9553 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.341 |
| p-value | 0.541 |
COSMIC
| Number Of Residues | 134 |
| Number Of SNVs | 4 |
| Number Of Permutations | 168 |
| Optimal Distance Threshold | 5.0 |
| K Statistic | 0.167 |
| p-value | 0.225 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 24 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | -0.38 |
| p-value | 0.402 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
