Assessment of Structural Intolerance and Durability
General Structure Information 2x2u RET first two cadherin-like domains from human ret 2.0Å AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 2rol CD3E structural basis of pxxdy motif recognition in sh3 binding -1.0Å AUTH O.AITIO,M.HELLMAN,T.KESTI,I.KLEINO,O.SAMUILOVA,AUTH 2 K.PAAKKONEN,H.TOSSAVAINEN,K.SAKSELA,P.PERMITITL STRUCTURAL BASIS OF PXXDY MOTIF RECOGNITION IN SH3TITL 2 BINDINGREF J.MOL.BIOL. V. 382 167 2008REFN ISSN 0022-2836PMID 18644376DOI 10.1016/J.JMB.2008.07.008 Variant Set Distributions Mapped Variants
General Structure Information 3fcs ITGA2B structure of complete ectodomain of integrin aiibb3 2.55Å AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped […]
General Structure Information 3g0f KIT kit kinase domain mutant d816h in complex with sunitinib 2.6Å AUTH K.S.GAJIWALA,J.C.WU,J.CHRISTENSEN,G.D.DESHMUKH,AUTH 2 W.DIEHL,J.P.DINITTO,J.M.ENGLISH,M.J.GREIG,Y.A.HE,AUTH 3 S.L.JACQUES,E.A.LUNNEY,M.MCTIGUE,D.MOLINA,AUTH 4 T.QUENZER,P.A.WELLS,X.YU,Y.ZHANG,A.ZOU,M.R.EMMETT,AUTH 5 A.G.MARSHALL,H.M.ZHANG,G.D.DEMETRITITL KIT KINASE MUTANTS SHOW UNIQUE MECHANISMS OF DRUGTITL 2 RESISTANCE TO IMATINIB AND SUNITINIB INTITL 3 GASTROINTESTINAL STROMAL TUMOR PATIENTS.REF PROC.NATL.ACAD.SCI.USA V. 106 1542 2009REFN ISSN 0027-8424PMID 19164557DOI 10.1073/PNAS.0812413106 Variant […]
General Structure Information 2knc ITGA2B platelet integrin alfaiib-beta3 transmembrane-cytoplasmic heterocomplex -1.0Å AUTH J.YANG,Y.Q.MA,R.C.PAGE,S.MISRA,E.F.PLOW,J.QINTITL STRUCTURE OF AN INTEGRIN ALPHAIIB BETA3TITL 2 TRANSMEMBRANE-CYTOPLASMIC HETEROCOMPLEX PROVIDES INSIGHTTITL 3 INTO INTEGRIN ACTIVATION.REF PROC.NATL.ACAD.SCI.USA V. 106 17729 2009REFN ISSN 0027-8424PMID 19805198DOI 10.1073/PNAS.0909589106 Variant Set Distributions Mapped Variants
General Structure Information 2v5o IGF2R structure of human igf2r domains 11-14 2.91Å AUTH J.BROWN,C.DELAINE,O.J.ZACCHEO,C.SIEBOLD,R.J.GILBERT,AUTH 2 G.VAN BOXEL,A.DENLEY,J.C.WALLACE,A.B.HASSAN,B.E.FORBES,AUTH 3 E.Y.JONESTITL STRUCTURE AND FUNCTIONAL ANALYSIS OF THE IGF-II/IGF2RTITL 2 INTERACTIONREF EMBO J. V. 27 265 2008REFN ISSN 0261-4189PMID 18046459DOI 10.1038/SJ.EMBOJ.7601938 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1n26 IL6R crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain 2.4Å AUTH J.N.VARGHESE,R.L.MORITZ,M.-Z.LOU,A.VAN DONKELAAR,H.JI,AUTH 2 N.IVANCIC,K.M.BRANSON,N.E.HALL,R.J.SIMPSONTITL STRUCTURE OF THE EXTRACELLULAR DOMAINS OF THE HUMANTITL 2 INTERLEUKIN-6 RECEPTOR ALPHA-CHAIN.REF PROC.NATL.ACAD.SCI.USA V. 99 15959 2002REFN ISSN 0027-8424PMID 12461182DOI 10.1073/PNAS.232432399 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic […]
General Structure Information 2x2m RET crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor 2.5Å AUTH L.MOLOGNI,R.ROSTAGNO,S.BRUSSOLO,P.P.KNOWLES,AUTH 2 S.KJAER,J.MURRAY-RUST,E.ROSSO,A.ZAMBON,L.SCAPOZZA,AUTH 3 N.Q.MCDONALD,V.LUCCHINI,C.GAMBACORTI-PASSERINITITL SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP ANDTITL 2 CRYSTALLOGRAPHIC STUDIES OF 3-SUBSTITUTED INDOLIN-TITL 3 2-ONE RET INHIBITORS.REF BIOORG.MED.CHEM. V. 18 1482 2010REFN ISSN 0968-0896PMID 20117004DOI 10.1016/J.BMC.2010.01.011 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 3it8 TNF crystal structure of tnf alpha complexed with a poxvirus mhc-related tnf binding protein 2.8Å AUTH Z.YANG,A.P.WEST JR.,P.J.BJORKMANTITL CRYSTAL STRUCTURE OF TNFA COMPLEXED WITH A POXVIRUSTITL 2 MHC-RELATED TNF BINDING PROTEINREF NAT.STRUCT.MOL.BIOL.REFN ESSN 1545-9985DOI 10.1038/NSMB.1683 Variant Set Distributions Mapped Variants
General Structure Information 3ije ITGB3 crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment 2.9Å AUTH J.P.XIONG,B.MAHALINGHAM,J.L.ALONSO,L.A.BORRELLI,X.RUI,AUTH 2 S.ANAND,B.T.HYMAN,T.RYSIOK,D.MULLER-POMPALLA,S.L.GOODMAN,AUTH 3 M.A.ARNAOUTTITL CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALPHAVBETA3TITL 2 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT.REF J.CELL BIOL. V. 186 589 2009REFN ISSN 0021-9525PMID 19704023DOI 10.1083/JCB.200905085 Variant Set Distributions Ripley’s K Analysis […]