Assessment of Structural Intolerance and Durability
General Structure Information 3ifq JUP interction of plakoglobin and beta-catenin with desmosomal cadherins 2.8Å AUTH H.J.CHOI,J.C.GROSS,S.POKUTTA,W.I.WEISTITL INTERACTIONS OF PLAKOGLOBIN AND BETA-CATENIN WITHTITL 2 DESMOSOMAL CADHERINS: BASIS OF SELECTIVE EXCLUSIONTITL 3 OF ALPHA- AND BETA-CATENIN FROM DESMOSOMES.REF J.BIOL.CHEM. V. 284 31776 2009REFN ISSN 0021-9258PMID 19759396DOI 10.1074/JBC.M109.047928 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 1zxq ICAM2 the crystal structure of icam-2 2.2Å AUTH J.M.CASASNOVAS,T.A.SPRINGER,J.H.LIU,S.C.HARRISON,J.H.WANGTITL CRYSTAL STRUCTURE OF ICAM-2 REVEALS A DISTINCTIVE INTEGRINTITL 2 RECOGNITION SURFACE.REF NATURE V. 387 312 1997REFN ISSN 0028-0836PMID 9153399DOI 10.1038/387312A0 Variant Set Distributions Mapped Variants
General Structure Information 3ry6 FCGR2A complex of fcgammariia (cd32) and the fc of human igg1 3.8Å AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 3hng FLT1 crystal structure of vegfr1 in complex with n-(4-chlorophenyl)-2- ((pyridin-4-ylmethyl)amino)benzamide 2.7Å AUTH L.TRESAUGUES,A.ROOS,C.H.ARROWSMITH,H.BERGLUND,C.BOUNTRA,AUTH 2 R.COLLINS,A.M.EDWARDS,S.FLODIN,A.FLORES,S.GRASLUND,AUTH 3 M.HAMMARSTROM,A.JOHANSSON,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,T.NYMAN,C.PERSSON,T.KRAGH-NIELSEN,AUTH 5 A.KOTZCH,J.SAGEMARK,H.SCHUELER,P.SCHUTZ,M.I.SIPONEN,AUTH 6 L.SVENSSON,A.G.THORSELL,S.VAN DER BERG,J.WEIGELT,M.WELIN,AUTH 7 M.WISNIEWSKA,P.NORDLUNDTITL CRYSTAL STRUCTURE OF VEGFR1 IN COMPLEX WITHTITL 2 N-(4-CHLOROPHENYL)-2-((PYRIDIN-4-YLMETHYL)AMINO)BENZAMIDEREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity […]
General Structure Information 3vwk CD1D ternary crystal structure of the human nkt tcr-cd1d-4deoxy-alpha- galactosylceramide complex 2.94Å AUTH K.S.WUN,F.ROSS,O.PATEL,G.S.BESRA,S.A.PORCELLI,AUTH 2 S.K.RICHARDSON,S.KESHIPEDDY,A.R.HOWELL,D.I.GODFREY,AUTH 3 J.ROSSJOHNTITL HUMAN AND MOUSE TYPE I NATURAL KILLER T CELL ANTIGENTITL 2 RECEPTORS EXHIBIT DIFFERENT FINE SPECIFICITIES FORTITL 3 CD1D-ANTIGEN COMPLEXREF J.BIOL.CHEM. V. 287 39139 2012REFN ISSN 0021-9258PMID 22995911DOI 10.1074/JBC.M112.412320 Variant Set Distributions Ripley’s […]
General Structure Information 3lqz HLA-DPA1 crystal structure of hla-dp2 3.25Å AUTH S.DAI,G.A.MURPHY,F.CRAWFORD,D.G.MACK,M.T.FALTA,P.MARRACK,AUTH 2 J.W.KAPPLER,A.P.FONTENOTTITL CRYSTAL STRUCTURE OF HLA-DP2 AND IMPLICATIONS FOR CHRONICTITL 2 BERYLLIUM DISEASE.REF PROC.NATL.ACAD.SCI.USA V. 107 7425 2010REFN ISSN 0027-8424PMID 20356827DOI 10.1073/PNAS.1001772107 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2k21 KCNE1 nmr structure of human kcne1 in lmpg micelles at ph 6.0 and 40 degree c -1.0Å AUTH C.KANG,C.TIAN,F.D.SONNICHSEN,J.A.SMITH,J.MEILER,AUTH 2 A.L.GEORGE,C.G.VANOYE,H.J.KIM,C.R.SANDERSTITL STRUCTURE OF KCNE1 AND IMPLICATIONS FOR HOW ITTITL 2 MODULATES THE KCNQ1 POTASSIUM CHANNEL.REF BIOCHEMISTRY V. 47 7999 2008REFN ISSN 0006-2960PMID 18611041DOI 10.1021/BI800875Q Variant Set Distributions Ripley’s K Analysis Plots […]
General Structure Information 3bu6 INSR crystal structure of the insulin receptor kinase in complex with irs2 krlb phosphopeptide 1.95Å AUTH J.WU,Y.D.TSENG,C.F.XU,T.A.NEUBERT,M.F.WHITE,AUTH 2 S.R.HUBBARDTITL STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF THETITL 2 KRLB REGION IN INSULIN RECEPTOR SUBSTRATE-2.REF NAT.STRUCT.MOL.BIOL. V. 15 251 2008REFN ISSN 1545-9993PMID 18278056DOI 10.1038/NSMB.1388 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2uzx MET structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i 2.8Å AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN […]
General Structure Information 3lco CSF1R inhibitor bound to a dfg-out structure of the kinase domain of csf-1r 3.4Å AUTH M.J.MEYERS,M.PELC,S.KAMTEKAR,J.DAY,G.I.PODA,M.K.HALL,AUTH 2 M.L.MICHENER,B.A.REITZ,K.J.MATHIS,B.S.PIERCE,M.D.PARIKH,AUTH 3 D.A.MISCHKE,S.A.LONG,J.J.PARLOW,D.R.ANDERSON,A.THORARENSENTITL STRUCTURE-BASED DRUG DESIGN ENABLES CONVERSION OF A DFG-INTITL 2 BINDING CSF-1R KINASE INHIBITOR TO A DFG-OUT BINDING MODE.REF BIOORG.MED.CHEM.LETT. V. 20 1543 2010REFN ISSN 0960-894XPMID 20137931DOI 10.1016/J.BMCL.2010.01.078 Variant Set Distributions Pathogenic […]