General Structure Information
| PDB ID | 3ry6 |
| HGNC Gene Label(s) | FCGR2A |
| Structure Name | complex of fcgammariia (cd32) and the fc of human igg1 |
| Resolution | 3.8Å |
| Reference | AUTH P.A.RAMSLAND,W.FARRUGIA,T.M.BRADFORD,C.T.SARDJONO,S.ESPARON,AUTH 2 H.M.TRIST,M.S.POWELL,P.S.TAN,A.C.CENDRON,B.D.WINES,AUTH 3 A.M.SCOTT,P.M.HOGARTHTITL STRUCTURAL BASIS FOR FC{GAMMA}RIIA RECOGNITION OF HUMAN IGGTITL 2 AND FORMATION OF INFLAMMATORY SIGNALING COMPLEXES.REF J.IMMUNOL. V. 187 3208 2011REFN ISSN 0022-1767PMID 21856937DOI 10.4049/JIMMUNOL.1101467 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 167 |
| Number Of SNVs | 31 |
| Number Of Permutations | 4490 |
| Optimal Distance Threshold | 6.0 |
| K Statistic | 0.034 |
| p-value | 0.728 |
COSMIC
| Number Of Residues | 167 |
| Number Of SNVs | 3 |
| Number Of Permutations | 109 |
| Optimal Distance Threshold | 23.0 |
| K Statistic | 0.333 |
| p-value | 1.0 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 31 |
| Number Of COSMIC SNVs | 3 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | -0.237 |
| p-value | 0.56 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
