General Structure Information
| PDB ID | 2uzx |
| HGNC Gene Label(s) | MET |
| Structure Name | structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i |
| Resolution | 2.8Å |
| Reference | AUTH H.H.NIEMANN,V.JAGER,P.J.G.BUTLER,J.VAN DEN HEUVEL,AUTH 2 S.SCHMIDT,D.FERRARIS,E.GHERARDI,D.W.HEINZTITL STRUCTURE OF THE HUMAN RECEPTOR TYROSINE KINASETITL 2 MET IN COMPLEX WITH THE LISTERIA INVASION PROTEINTITL 3 INLBREF CELL(CAMBRIDGE,MASS.) V. 130 235 2007REFN ISSN 0092-8674PMID 17662939DOI 10.1016/J.CELL.2007.05.037 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 547 |
| Number Of SNVs | 127 |
| Number Of Permutations | 40901 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.02 |
| p-value | 0.495 |
COSMIC
| Number Of Residues | 547 |
| Number Of SNVs | 13 |
| Number Of Permutations | 7235 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.115 |
| p-value | 0.632 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 127 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.025 |
| p-value | 0.518 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
Mapped Variants
[+] ExAC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:116339280 | rs374050750 COSM327149 |
A>T | B:48 | (35.76, -50.75, 5.22) |
| 7:116339281 | rs80256822 | A>G | B:48 | (35.76, -50.75, 5.22) |
| 7:116339289 | P>S | B:51 | (38.92, -46.37, 0.70) | |
| 7:116339292 | I>V | B:52 | (36.01, -43.70, 3.42) | |
| 7:116339317 | H>R | B:60 | (18.90, -40.50, 13.35) | |
| 7:116339318 | H>Q | B:60 | (18.90, -40.50, 13.35) | |
| 7:116339334 | A>S | B:66 | (33.31, -45.75, -1.03) | |
| 7:116339337 | rs202047059 | T>P | B:67 | (36.03, -47.43, -3.45) |
| 7:116339338 | rs200023903 | T>N | B:67 | (36.03, -47.43, -3.45) |
| 7:116339352 | V>L | B:72 | (24.00, -47.34, 5.55) | |
| 7:116339368 | D>A | B:77 | (26.20, -48.42, 16.94) | |
| 7:116339370 | L>F | B:78 | (29.03, -46.48, 13.66) | |
| 7:116339379 | V>F | B:81 | (22.07, -51.32, 8.23) | |
| 7:116339380 | V>A | B:81 | (22.07, -51.32, 8.23) | |
| 7:116339387 | COSM4153775 | E>D | B:83 | (25.82, -52.78, 1.30) |
| 7:116339469 | rs368750834 | V>I | B:111 | (38.97, -51.49, -19.39) |
| 7:116339493 | A>T | B:119 | (29.35, -37.50, -4.05) | |
| 7:116339505 | D>N | B:123 | (17.17, -33.86, -1.57) | |
| 7:116339515 | rs542267057 | Y>C | B:126 | (11.76, -33.30, -6.12) |
| 7:116339520 | D>N | B:128 | (12.50, -39.42, 0.65) | |
| 7:116339544 | rs199701987 | V>I | B:136 | (33.76, -44.60, -13.98) |
| 7:116339563 | Q>R | B:142 | (23.39, -43.46, -8.95) | |
| 7:116339566 | rs35469582 | R>Q | B:143 | (16.98, -41.44, -8.67) |
| 7:116339584 | COSM3669677 | N>S | B:149 | (10.03, -45.19, 7.34) |
| 7:116339605 | rs56311081 | S>L | B:156 | (17.36, -51.37, -3.98) |
| 7:116339641 | COSM1447446 | E>G | B:168 | (23.35, -34.66, -30.38) |
| 7:116339642 | rs55985569 | E>D | B:168 | (23.35, -34.66, -30.38) |
| 7:116339673 | A>T | B:179 | (38.52, -38.05, -11.50) | |
| 7:116339679 | G>R | B:181 | (38.18, -33.57, -8.56) | |
| 7:116339691 | rs376097698 | L>I | B:185 | (27.10, -27.46, -3.24) |
| 7:116339715 | I>L | B:193 | (17.47, -29.72, -7.35) | |
| 7:116339745 | rs200861145 | S>T | B:203 | (43.57, -32.58, -21.91) |
| 7:116339770 | rs45483396 | L>W | B:211 | (33.83, -32.11, -17.52) |
| 7:116339776 | rs367722737 COSM257403 |
S>L | B:213 | (35.38, -25.88, -13.79) |
| 7:116339784 | rs571453992 | V>M | B:216 | (25.01, -24.39, -12.26) |
| 7:116339803 | rs200776610 | T>M | B:222 | (11.88, -35.92, -14.88) |
| 7:116339808 | D>Y | B:224 | (15.58, -38.16, -16.18) | |
| 7:116339827 | T>M | B:230 | (22.97, -19.89, -20.17) | |
| 7:116339847 | V>I | B:237 | (39.96, -23.14, -18.20) | |
| 7:116339851 | rs34349517 | L>S | B:238 | (41.07, -20.70, -21.78) |
| 7:116339859 | F>L | B:241 | (45.85, -21.31, -20.18) | |
| 7:116339871 | Y>H | B:245 | (49.72, -23.83, -13.82) | |
| 7:116339877 | I>V | B:247 | (41.98, -25.26, -10.20) | |
| 7:116339881 | K>M | B:248 | (43.02, -29.13, -6.87) | |
| 7:116339896 | F>C | B:253 | (30.91, -22.35, 1.86) | |
| 7:116339907 | N>D | B:257 | (21.95, -15.65, 0.10) | |
| 7:116339908 | COSM1084381 | N>S | B:257 | (21.95, -15.65, 0.10) |
| 7:116339919 | F>L | B:261 | (33.45, -23.30, -4.66) | |
| 7:116339926 | COSM1084383 | T>M | B:263 | (40.88, -22.78, -4.44) |
| 7:116339938 | E>G | B:267 | (50.35, -16.52, -7.24) | |
| 7:116339941 | T>I | B:268 | (49.98, -15.78, -11.83) | |
| 7:116339959 | F>S | B:274 | (50.92, -22.91, -6.48) | |
| 7:116339964 | T>A | B:276 | (44.48, -20.09, -1.18) | |
| 7:116339977 | R>M | B:280 | (31.10, -13.83, -3.70) | |
| 7:116339990 | I>M | B:284 | (19.52, -16.10, -11.25) | |
| 7:116340039 | rs201687037 | T>A | B:301 | (54.31, -13.01, 13.85) |
| 7:116340086 | rs35225896 | I>M | B:316 | (48.52, -24.50, 0.73) |
| 7:116340087 | L>I | B:317 | (43.61, -24.67, 2.22) | |
| 7:116340097 | rs35776110 | A>V | B:320 | (37.83, -26.20, 5.75) |
| 7:116340105 | rs201467281 | S>G | B:323 | (30.93, -22.46, 12.10) |
| 7:116340109 | K>R | B:324 | (28.15, -20.44, 14.02) | |
| 7:116340112 | P>L | B:325 | (31.13, -18.18, 16.94) | |
| 7:116340142 | A>D | B:335 | (31.43, -11.64, 16.06) | |
| 7:116340156 | D>N | B:340 | (29.04, -18.00, 9.39) | |
| 7:116340157 | rs200690492 | D>G | B:340 | (29.04, -18.00, 9.39) |
| 7:116340165 | F>L | B:343 | (37.16, -21.95, 11.63) | |
| 7:116340168 | G>R | B:344 | (41.44, -22.52, 7.88) | |
| 7:116340177 | rs200074800 | A>T | B:347 | (50.43, -24.98, 4.70) |
| 7:116340186 | rs201191014 | K>Q | B:350 | (57.38, -28.29, -0.97) |
| 7:116340189 | P>T | B:351 | (59.73, -25.09, -3.17) | |
| 7:116340201 | rs561295443 | E>K | B:355 | (53.98, -30.71, -2.82) |
| 7:116340210 | D>H | B:358 | (55.51, -31.38, 7.89) | |
| 7:116340223 | rs77523018 | M>T | B:362 | (44.10, -21.72, 12.13) |
| 7:116340228 | rs200016433 | A>T | B:364 | (39.62, -16.98, 11.04) |
| 7:116340237 | I>V | B:367 | (31.80, -14.70, 5.77) | |
| 7:116340252 | D>N | B:372 | (33.43, -5.70, 3.71) | |
| 7:116340254 | D>E | B:372 | (33.43, -5.70, 3.71) | |
| 7:116340262 | rs33917957 | N>S | B:375 | (31.39, -5.50, -1.27) |
| 7:116340292 | C>Y | B:385 | (40.25, -9.99, -15.95) | |
| 7:116340316 | N>S | B:393 | (44.04, -9.77, -23.88) | |
| 7:116371797 | COSM1496451 | R>C | B:426 | (43.79, -12.26, 9.33) |
| 7:116371800 | rs376364468 | V>I | B:427 | (47.03, -14.17, 12.32) |
| 7:116371801 | COSM3778048 | V>A | B:427 | (47.03, -14.17, 12.32) |
| 7:116371807 | L>S | B:429 | (44.21, -18.59, 16.17) | |
| 7:116371812 | M>V | B:431 | (50.69, -17.91, 18.67) | |
| 7:116371843 | COSM1548082 | S>F | B:441 | (41.40, -32.15, 9.74) |
| 7:116371845 | rs532124885 | I>V | B:442 | (39.04, -28.53, 10.84) |
| 7:116371864 | G>E | B:448 | (30.09, -22.44, 26.26) | |
| 7:116371884 | L>F | B:455 | (42.72, -30.71, 14.86) | |
| 7:116371903 | rs544274181 | R>H | B:461 | (48.42, -37.53, 16.66) |
| 7:116371908 | rs562564732 | M>V | B:463 | (44.40, -32.94, 18.42) |
| 7:116380004 | V>F | B:465 | (42.30, -27.29, 20.71) | |
| 7:116380017 | COSM1084395 | R>Q | B:469 | (42.75, -12.82, 18.36) |
| 7:116380025 | rs376589619 | P>S | B:472 | (47.97, -20.77, 22.68) |
| 7:116380061 | COSM3632207 | H>Y | B:484 | (45.64, -43.05, 6.93) |
| 7:116380062 | H>R | B:484 | (45.64, -43.05, 6.93) | |
| 7:116380083 | rs561588772 | I>T | B:491 | (30.38, -35.10, 10.60) |
| 7:116380085 | V>M | B:492 | (29.84, -31.99, 14.02) | |
| 7:116380095 | rs45585831 | T>R | B:495 | (22.53, -31.02, 20.41) |
| 7:116380100 | N>D | B:497 | (19.65, -31.64, 26.30) | |
| 7:116380101 | N>S | B:497 | (19.65, -31.64, 26.30) | |
| 7:116380109 | G>S | B:500 | (28.27, -35.10, 21.13) | |
| 7:116380112 | rs546559782 | Y>H | B:501 | (28.66, -37.23, 17.19) |
| 7:116380137 | K>M | B:509 | (38.87, -46.12, 10.83) | |
| 7:116380910 | rs371124109 | T>M | B:511 | (35.88, -42.85, 14.65) |
| 7:116380930 | L>M | B:518 | (38.73, -38.94, 26.07) | |
| 7:116380978 | rs200283364 | P>S | B:534 | (35.72, -26.60, 32.37) |
| 7:116381003 | H>R | B:542 | (49.31, -36.36, 46.08) | |
| 7:116381005 | COSM3632210 | D>N | B:543 | (49.21, -39.02, 43.14) |
| 7:116381014 | V>M | B:546 | (40.89, -37.70, 38.47) | |
| 7:116381018 | COSM3632211 | R>Q | B:547 | (35.24, -37.14, 37.20) |
| 7:116381021 | S>L | B:548 | (35.37, -35.69, 41.87) | |
| 7:116381026 | rs561347675 | E>K | B:550 | (37.21, -41.64, 40.92) |
| 7:116381038 | rs200218511 | G>R | B:554 | (40.75, -35.12, 50.59) |
| 7:116381039 | G>A | B:554 | (40.75, -35.12, 50.59) | |
| 7:116381041 | rs370883654 | T>A | B:555 | (43.17, -33.39, 48.14) |
| 7:116381047 | rs374733251 | T>A | B:557 | (42.27, -29.23, 43.42) |
| 7:116381071 | I>V | B:565 | (62.92, -27.10, 42.76) | |
| 7:116381077 | K>E | B:567 | (69.29, -28.89, 39.57) | |
| 7:116395413 | F>S | B:569 | (71.56, -25.54, 35.78) | |
| 7:116395418 | N>D | B:571 | (75.68, -25.25, 41.43) | |
| 7:116395420 | N>K | B:571 | (75.68, -25.25, 41.43) | |
| 7:116395422 | S>N | B:572 | (78.12, -21.44, 41.81) | |
| 7:116395430 | L>I | B:575 | (80.93, -12.19, 44.86) | |
| 7:116395456 | I>M | B:583 | (65.14, -22.56, 38.39) | |
| 7:116395477 | rs199542598 | F>L | B:590 | (48.33, -18.46, 40.18) |
| 7:116395478 | rs45602940 | R>W | B:591 | (43.40, -21.38, 37.98) |
| 7:116395479 | R>L | B:591 | (43.40, -21.38, 37.98) | |
| 7:116395517 | rs201861645 | L>V | B:604 | (64.18, -15.23, 47.50) |
| 7:116395520 | L>F | B:605 | (69.11, -15.79, 46.80) | |
| 7:116395528 | N>K | B:607 | (67.64, -11.43, 52.27) | |
| 7:116395560 | T>M | B:618 | (58.31, -21.83, 31.43) | |
| 7:116395569 | rs375951814 | T>I | B:621 | (62.00, -23.03, 32.98) |
| 7:116397492 | L>V | B:622 | (62.42, -20.26, 36.25) | |
| 7:116397502 | T>I | B:625 | (69.35, -11.85, 36.91) | |
| 7:116397532 | N>S | B:635 | (75.41, -22.43, 51.44) | |
| 7:116397535 | M>K | B:636 | (72.43, -19.07, 49.83) | |
| 7:116397561 | G>R | B:645 | (53.58, -21.57, 47.35) | |
| 7:116397565 | T>K | B:646 | (56.82, -22.18, 49.05) | |
| 7:116397567 | T>A | B:647 | (59.77, -24.61, 47.24) | |
| 7:116397568 | T>R | B:647 | (59.77, -24.61, 47.24) | |
| 7:116397698 | V>I | B:658 | (89.11, -18.23, 43.50) |
[+] COSMIC Missense Variants
| Position | Variant | AA Change | PDB Chain Position | Structure Coordinates |
|---|---|---|---|---|
| 7:116339642 | COSM706 | E>D | B:168 | (23.35, -34.66, -30.38) |
| 7:116339776 | COSM257403 | S>L | B:213 | (35.38, -25.88, -13.79) |
| 7:116339800 | COSM71623 | E>G | B:221 | (10.45, -32.31, -12.93) |
| 7:116339811 | COSM1722239 | G>S | B:225 | (18.23, -35.00, -15.81) |
| 7:116339812 | COSM452183 | G>D | B:225 | (18.23, -35.00, -15.81) |
| 7:116339926 | COSM1084383 | T>M | B:263 | (40.88, -22.78, -4.44) |
| 7:116339934 | COSM1447451 | R>G | B:266 | (47.00, -20.75, -11.29) |
| 7:116340097 | COSM3877459 | A>V | B:320 | (37.83, -26.20, 5.75) |
| 7:116340135 | COSM1579016 | I>L | B:333 | (36.54, -11.88, 15.89) |
| 7:116340214 | COSM1286164 | R>Q | B:359 | (56.23, -25.38, 8.65) |
| 7:116380017 | COSM1084395 | R>Q | B:469 | (42.75, -12.82, 18.36) |
| 7:116380037 | COSM598584 | H>Y | B:476 | (41.53, -31.12, 25.62) |
| 7:116380094 | COSM3381725 | T>S | B:495 | (22.53, -31.02, 20.41) |
| 7:116395536 | COSM106579 | C>Y | B:610 | (65.70, -13.17, 41.66) |