3FCS.C | ITGA2B

General Structure Information

PDB ID	3fcs
HGNC Gene Label(s)	ITGA2B
Structure Name	structure of complete ectodomain of integrin aiibb3
Resolution	2.55Å
Reference	AUTH J.ZHU,B.H.LUO,T.XIAO,C.ZHANG,N.NISHIDA,T.A.SPRINGERTITL STRUCTURE OF A COMPLETE INTEGRIN ECTODOMAIN IN A PHYSIOLOGICTITL 2 RESTING STATE AND ACTIVATION AND DEACTIVATION BY APPLIEDTITL 3 FORCES.REF MOL.CELL V. 32 849 2008REFN ISSN 1097-2765PMID 19111664DOI 10.1016/J.MOLCEL.2008.11.018

Variant Set Distributions

ExAC Variants

Number Of Residues	903
Number Of SNVs	203
Number Of Permutations	70373
Optimal Distance Threshold	20.0
K Statistic	0.098
p-value	0.1

ClinVar

Number Of Residues	903
Number Of SNVs	9
Number Of Permutations	4301
Optimal Distance Threshold	7.0
K Statistic	0.028
p-value	0.791

COSMIC

Number Of Residues	903
Number Of SNVs	9
Number Of Permutations	7657
Optimal Distance Threshold	4.0
K Statistic	0.028
p-value	0.968

Ripley’s K Analysis Plots

ExACClinVarCOSMIC

Variant Set Comparisons

ClinVar vs. ExAC

Number Of ExAC SNVs	203
Number Of ClinVar SNVs	9
Optimal Distance Threshold	16.0
K Statistic	0.051
p-value	0.583

Cosmic vs. ExAC

Number Of ExAC SNVs	203
Number Of COSMIC SNVs	9
Optimal Distance Threshold	4.0
K Statistic	0.027
p-value	0.491

Mapped Variants

[+] ExAC Missense Variants

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:42466744		N>S	C:2	(-6.80, 21.10, -10.23)
17:42466738	rs549088938	D>G	C:4	(-3.98, 26.61, -15.09)
17:42466739		D>H	C:4	(-3.98, 26.61, -15.09)
17:42466727		L>F	C:8	(-0.24, 31.98, -15.01)
17:42466723	rs5915	T>I	C:9	(-2.01, 36.01, -12.95)
17:42466724	rs77120952	T>A	C:9	(-2.01, 36.01, -12.95)
17:42466714	rs559994522	A>V	C:12	(4.10, 43.73, -9.79)
17:42466705		N>S	C:15	(13.11, 47.16, -8.80)
17:42466702	rs376817155	G>D	C:16	(13.63, 46.16, -4.76)
17:42466654		R>K	C:32	(-14.99, 42.82, -4.07)
17:42463419		R>K	C:59	(-6.41, 42.90, -11.95)
17:42463416		A>V	C:60	(-6.67, 38.00, -14.89)
17:42463413		E>G	C:61	(-5.31, 41.32, -16.27)
17:42463404	rs201860267	Q>R	C:64	(1.31, 47.48, -11.37)
17:42463402		C>S	C:65	(-0.89, 47.16, -7.13)
17:42463378		R>G	C:73	(6.14, 61.19, 10.17)
17:42463284		E>K	C:75	(7.28, 58.51, 15.93)
17:42463246	COSM1679862	F>L	C:87	(14.34, 54.91, 15.35)
17:42463200	rs370013826	V>I	C:103	(-8.56, 43.78, 9.17)
17:42463083		A>G	C:106	(1.33, 44.90, 8.85)
17:42463072	rs559891307	W>G	C:110	(13.52, 43.59, 10.63)
17:42463054	rs76066357	L>V	C:116	(16.78, 58.89, 25.66)
17:42463048		K>E	C:118	(19.35, 62.59, 32.44)
17:42463036	rs199641871	A>T	C:122	(17.33, 51.46, 26.53)
17:42463033		E>K	C:123	(20.13, 49.58, 24.56)
17:42463018		G>S	C:128	(8.92, 45.90, 16.68)
17:42462998		Q>H	C:134	(-10.87, 49.04, 8.58)
17:42462996		P>L	C:135	(-9.43, 49.31, 4.11)
17:42462997		P>S	C:135	(-9.43, 49.31, 4.11)
17:42462982		R>G	C:140	(-5.06, 52.93, 9.28)
17:42462976	COSM3795670	E>K	C:142	(0.42, 51.47, 15.57)
17:42462966	rs148327798	P>H	C:145	(4.24, 44.44, 22.32)
17:42462948	rs373979894	L>Q	C:151	(17.17, 52.42, 31.84)
17:42462942		R>H	C:153	(21.02, 50.79, 35.60)
17:42462934		V>M	C:156	(22.96, 44.39, 33.76)
17:42462931		E>K	C:157	(21.39, 45.46, 38.09)
17:42462925		D>Y	C:159	(21.25, 38.50, 34.84)
17:42462919		S>G	C:161	(15.28, 39.08, 33.01)
17:42462670		S>N	C:172	(5.54, 35.57, 12.93)
17:42462576	rs143284768	A>V	C:178	(-11.89, 35.22, 17.27)
17:42462565		V>M	C:182	(-0.71, 35.60, 17.32)
17:42462562	rs369874789	L>F	C:183	(2.64, 38.66, 16.98)
17:42462436		A>T	C:196	(2.14, 38.13, 21.31)
17:42462430		A>T	C:198	(-4.31, 40.39, 21.12)
17:42462405		S>N	C:206	(-5.98, 51.06, 22.89)
17:42462393		G>A	C:210	(1.24, 60.02, 20.54)
17:42462394	rs149574963	G>S	C:210	(1.24, 60.02, 20.54)
17:42462388		L>F	C:212	(4.98, 55.89, 21.27)
17:42462382		W>R	C:214	(0.16, 51.46, 23.52)
17:42462357		S>C	C:222	(5.45, 34.20, 26.70)
17:42462346		S>G	C:226	(16.49, 29.00, 33.07)
17:42462324		G>A	C:233	(15.71, 29.31, 19.48)
17:42462322	rs368697593	Y>H	C:234	(16.20, 32.14, 17.16)
17:42461947		S>L	C:238	(6.80, 29.98, 13.16)
17:42461939		V>M	C:241	(-3.77, 28.39, 14.97)
17:42461931		E>D	C:243	(-8.31, 21.91, 18.27)
17:42461707		A>V	C:257	(12.06, 26.59, 17.45)
17:42461705	rs370889770	P>S	C:258	(14.29, 26.80, 14.54)
17:42461702		T>S	C:259	(17.66, 27.07, 16.86)
17:42461695		S>N	C:261	(18.54, 22.19, 21.62)
17:42461684		G>R	C:265	(14.89, 21.68, 17.01)
17:42461494	rs560777742	D>N	C:271	(-2.39, 26.49, 26.34)
17:42461484		Y>C	C:274	(1.37, 31.22, 26.13)
17:42461472		H>R	C:278	(1.91, 17.97, 22.04)
17:42461464		R>S	C:281	(13.05, 16.48, 20.19)
17:42461310	COSM3691991 COSM3691992	A>V	C:286	(21.07, 22.39, 11.23)
17:42461311	rs184526164	A>T	C:286	(21.07, 22.39, 11.23)
17:42461276	COSM187698 COSM3691990	D>E	C:297	(-7.94, 17.34, 8.22)
17:42461269		G>R	C:300	(-10.76, 13.43, 7.00)
17:42461070		R>K	C:303	(-8.97, 14.03, 14.33)
17:42461053		G>S	C:309	(9.81, 22.37, 8.45)
17:42461011		A>T	C:323	(22.60, 16.07, 0.99)
17:42461008	rs137852910	E>K	C:324	(21.06, 20.99, 1.70)
17:42461004		V>A	C:325	(17.29, 18.24, 0.25)
17:42460996		V>L	C:328	(8.05, 17.85, 5.11)
17:42460977	rs553981786	P>L	C:334	(-4.63, 11.15, 17.60)
17:42460974	COSM3691612 COSM3691613	R>Q	C:335	(-10.05, 8.63, 18.62)
17:42460968	rs201917696	P>L	C:337	(-5.49, 11.97, 25.14)
17:42460964	rs187264223	H>Q	C:338	(-3.58, 9.18, 22.72)
17:42460966	rs374323511	H>D	C:338	(-3.58, 9.18, 22.72)
17:42460953		A>V	C:342	(5.98, 9.41, 14.96)
17:42460924		L>F	C:352	(21.61, 19.95, -3.93)
17:42460920	rs370148124	Y>C	C:353	(22.47, 23.14, -1.74)
17:42460914	COSM335057	R>Q	C:355	(16.43, 26.53, 1.19)
17:42460897		A>T	C:361	(0.21, 25.50, 2.08)
17:42460887		G>D	C:364	(-7.66, 22.46, 0.76)
17:42460879		D>N	C:367	(-9.65, 17.65, -5.85)
17:42460875	rs146983962	R>Q	C:368	(-14.64, 19.86, -4.27)
17:42458426	rs75622274 CM021109	I>S	C:374	(-0.46, 20.24, 1.20)
17:42458415		A>T	C:378	(11.36, 24.81, -3.37)
17:42458411		P>L	C:379	(12.73, 28.12, -2.99)
17:42458408	rs373586333	Y>C	C:380	(16.45, 28.56, -3.92)
17:42458405		G>E	C:381	(14.39, 24.01, -7.21)
17:42458391	rs140253829	R>W	C:386	(14.62, 28.34, -12.60)
17:42458384		Q>R	C:388	(9.83, 23.30, -7.86)
17:42458342	rs557705725	R>H	C:402	(5.21, 9.46, -5.47)
17:42458343	rs532414080	R>C	C:402	(5.21, 9.46, -5.47)
17:42458309		T>I	C:413	(17.85, 32.78, -11.12)
17:42458285		L>R	C:421	(2.94, 29.78, -0.15)
17:42458282	rs75998071	R>Q	C:422	(-1.13, 32.31, 2.34)
17:42458263		D>E	C:428	(-12.40, 32.62, -9.64)
17:42458265	rs181511536	D>N	C:428	(-12.40, 32.62, -9.64)
17:42458262	rs200018801	D>H	C:429	(-16.77, 32.46, -7.56)
17:42458258		N>S	C:430	(-14.51, 28.14, -9.58)
17:42458005	rs568782461	V>M	C:437	(3.28, 32.02, -5.45)
17:42457993	rs375195998 COSM75038	G>R	C:441	(13.35, 38.59, -6.25)
17:42457985		N>K	C:443	(10.07, 42.16, -7.21)
17:42457975		V>M	C:447	(-2.23, 33.61, -9.40)
17:42457971		Y>C	C:448	(-0.49, 29.18, -10.10)
17:42457857		A>T	C:450	(-8.60, 25.80, -9.92)
17:42457839		A>S	C:456	(-15.01, 9.54, -15.00)
17:42457797	rs375026275	V>M	C:470	(-26.72, -19.53, -31.73)
17:42457792		K>N	C:471	(-26.24, -18.47, -36.35)
17:42457790	rs281864910 CM111089	S>N	C:472	(-30.30, -14.98, -34.11)
17:42457781		L>P	C:475	(-25.05, -9.55, -42.13)
17:42457772		T>I	C:478	(-27.28, -9.60, -46.51)
17:42457770		K>E	C:479	(-30.98, -12.61, -46.03)
17:42457763		P>H	C:481	(-26.71, -16.37, -40.94)
17:42457764		P>T	C:481	(-26.71, -16.37, -40.94)
17:42457761	rs112836157	V>M	C:482	(-24.77, -13.93, -37.64)
17:42457661		I>N	C:487	(-21.87, -4.57, -26.40)
17:42457656		M>V	C:489	(-21.19, 1.66, -23.84)
17:42457643		A>D	C:493	(-19.99, 12.68, -15.33)
17:42457629	rs138393499	I>L	C:498	(-19.19, 20.47, -14.27)
17:42457518		L>Q	C:504	(-16.86, 12.75, -23.11)
17:42457516		N>H	C:505	(-15.02, 11.31, -27.21)
17:42457513		A>S	C:506	(-16.32, 6.80, -26.60)
17:42457510		E>K	C:507	(-12.33, 4.27, -28.64)
17:42457494	rs139770734	R>Q	C:512	(-7.38, -3.43, -27.54)
17:42457485		P>L	C:515	(-4.42, -8.73, -34.79)
17:42457482		R>H	C:516	(-4.97, -3.04, -37.53)
17:42457483	rs372316950	R>C	C:516	(-4.97, -3.04, -37.53)
17:42457473		R>Q	C:519	(-9.70, -7.46, -34.31)
17:42457470		R>Q	C:520	(-11.80, -13.63, -32.31)
17:42457452		S>Y	C:526	(-19.78, -1.35, -39.53)
17:42457429		N>D	C:534	(-19.89, 11.78, -29.73)
17:42457414	rs146382550	G>R	C:539	(-26.38, 17.87, -17.01)
17:42457383		M>T	C:549	(-25.81, -5.48, -32.20)
17:42457384		M>V	C:549	(-25.81, -5.48, -32.20)
17:42457371		R>Q	C:553	(-14.93, -13.49, -38.46)
17:42457173		D>H	C:557	(-13.14, -16.98, -41.26)
17:42457166	COSM3191089	R>Q	C:559	(-6.57, -22.18, -34.92)
17:42457167	rs373204738 COSM3378215	R>W	C:559	(-6.57, -22.18, -34.92)
17:42457163		D>A	C:560	(-8.24, -18.58, -31.31)
17:42457148	rs76811038	I>T	C:565	(-13.17, -11.98, -27.06)
17:42457121	rs141778911	P>L	C:574	(-13.18, 16.86, -26.68)
17:42457115	rs539187844 COSM3742266	T>M	C:576	(-9.08, 22.54, -27.79)
17:42457107		G>R	C:579	(-6.22, 28.68, -29.19)
17:42457102	rs150648605	M>I	C:580	(-5.11, 26.17, -27.34)
17:42457104		M>V	C:580	(-5.11, 26.17, -27.34)
17:42457089	rs141885563	V>M	C:585	(-9.36, 18.25, -15.41)
17:42456045	rs111657038	V>I	C:607	(-24.31, -22.90, -19.46)
17:42455875	rs78299130	T>M	C:619	(-0.26, -19.93, 10.51)
17:42455872		G>D	C:620	(0.24, -17.77, 14.01)
17:42455866	rs375936260 COSM979955	P>L	C:622	(-1.27, -16.10, 18.52)
17:42455864		L>F	C:623	(-2.48, -11.63, 16.94)
17:42455855		G>R	C:626	(2.21, -4.45, 20.11)
17:42455852		A>T	C:627	(3.30, -6.15, 17.55)
17:42455822	rs149991452	A>T	C:637	(-9.05, -23.61, -3.85)
17:42455815		N>S	C:639	(-14.11, -25.98, -9.62)
17:42455813	rs139410216	E>K	C:640	(-15.95, -30.08, -7.23)
17:42455807	rs368974006	E>K	C:642	(-18.94, -26.40, -15.44)
17:42455791	rs200481952	A>V	C:647	(-10.88, -16.45, -11.26)
17:42455775		H>Q	C:652	(-12.43, -8.93, 2.39)
17:42455771	rs191789319	P>T	C:654	(-8.23, -6.35, 8.81)
17:42455762	COSM979953	A>T	C:657	(-3.92, -5.68, 7.71)
17:42455750		R>W	C:661	(5.20, -13.39, -0.07)
17:42455747	COSM561020	A>T	C:662	(1.83, -14.65, -2.40)
17:42455732	rs145553601	E>K	C:667	(3.67, -26.31, -10.50)
17:42455154		F>S	C:669	(2.22, -20.68, -11.06)
17:42455120	rs140919615	N>K	C:680	(-13.64, -2.15, -1.84)
17:42455111	COSM4066909	R>S	C:683	(-6.86, -2.36, 3.17)
17:42455112		R>T	C:683	(-6.86, -2.36, 3.17)
17:42455086		P>S	C:692	(-10.63, -20.63, -17.28)
17:42455075		K>N	C:695	(-14.11, -29.91, -13.99)
17:42455074		N>D	C:696	(-11.76, -31.18, -11.28)
17:42455070	COSM979951	A>V	C:697	(-9.26, -27.38, -10.03)
17:42454446	rs201042087	A>V	C:702	(0.18, -18.81, 0.69)
17:42454447		A>P	C:702	(0.18, -18.81, 0.69)
17:42454438		V>L	C:705	(-0.58, -10.82, 6.37)
17:42454432	rs576365165	V>M	C:707	(-1.31, -7.59, 11.74)
17:42454401		V>G	C:717	(-9.09, -9.89, 14.18)
17:42454402	rs139086448	V>M	C:717	(-9.09, -9.89, 14.18)
17:42454390	COSM1325034 CM021111	L>V	C:721	(-11.68, -15.62, 2.88)
17:42453747		S>R	C:728	(-24.15, -16.09, -14.92)
17:42453749		S>C	C:728	(-24.15, -16.09, -14.92)
17:42453727		I>T	C:735	(-18.41, -16.16, 2.79)
17:42453721		L>P	C:737	(-15.46, -15.71, 8.26)
17:42453704	rs547581737	R>W	C:743	(-4.54, -13.91, 23.69)
17:42453688		V>A	C:748	(10.88, -9.29, 31.82)
17:42453686		E>K	C:749	(15.68, -10.72, 30.77)
17:42453683	rs542591743	L>V	C:750	(16.70, -10.35, 35.56)
17:42453679	COSM1383667 COSM359101	R>Q	C:751	(21.61, -10.54, 32.71)
17:42453538	rs142445733	A>D	C:757	(34.75, -11.32, 39.92)
17:42453335		G>R	C:792	(4.10, -5.61, 26.21)
17:42453331		T>S	C:793	(3.38, -2.55, 28.23)
17:42453322		G>V	C:796	(3.88, -2.91, 38.45)
17:42453313		L>R	C:799	(12.87, -5.85, 42.32)
17:42453299		P>A	C:804	(24.43, -10.77, 52.33)
17:42453295		G>E	C:805	(23.74, -8.98, 55.82)
17:42453291	rs377753373	Q>H	C:806	(21.55, -6.94, 59.03)
17:42453292		Q>R	C:806	(21.55, -6.94, 59.03)
17:42453269	rs376469783	Y>H	C:814	(29.20, -1.69, 55.58)
17:42453247	rs373957549 CD021197	Q>L	C:821	(19.02, 3.98, 36.44)
17:42453245	rs571337941	G>R	C:822	(14.52, 4.01, 35.74)
17:42453235		Q>L	C:825	(11.48, 4.57, 43.98)
17:42453084	rs74988902	V>M	C:837	(29.47, 8.22, 56.07)
17:42452970		P>S	C:875	(33.96, -23.76, 48.90)
17:42452963		L>R	C:877	(28.00, -20.59, 50.00)
17:42452960		V>A	C:878	(28.50, -16.44, 52.05)
17:42452961	rs573974230	V>L	C:878	(28.50, -16.44, 52.05)
17:42452441		D>E	C:891	(8.37, -0.20, 43.34)
17:42452425		R>C	C:897	(8.54, -2.75, 22.59)
17:42452096		H>Q	C:927	(18.30, -14.35, 44.69)
17:42452097		H>L	C:927	(18.30, -14.35, 44.69)
17:42452095		A>S	C:928	(16.56, -11.57, 42.71)
17:42452088		F>C	C:930	(10.88, -10.48, 38.13)
17:42452080		S>T	C:933	(0.60, -6.35, 38.22)
17:42452064	rs542131408	A>V	C:938	(-8.26, -5.03, 27.07)
17:42452061		V>A	C:939	(-8.57, -8.81, 26.51)
17:42452055	rs551266734	P>L	C:941	(-5.59, -13.63, 27.92)
17:42452056		P>S	C:941	(-5.59, -13.63, 27.92)
17:42451819	rs368536313	R>Q	C:957	(42.61, -15.92, 51.08)
17:42451820		R>W	C:957	(42.61, -15.92, 51.08)
17:42451817	rs78165611	A>T	C:958	(46.99, -13.96, 49.62)

Position	Variant	AA Change	PDB Chain Position	Structure Coordinates
17:42463002	COSM145522	A>V	C:133	(-5.86, 48.23, 8.46)
17:42461310	COSM3691991	A>V	C:286	(21.07, 22.39, 11.23)
17:42461019	COSM4267642	R>Q	C:320	(27.37, 15.37, -1.42)
17:42458356	COSM4267632	E>D	C:397	(-3.65, 6.07, 5.06)
17:42457993	COSM75038	G>R	C:441	(13.35, 38.59, -6.25)
17:42457990	COSM472883	A>T	C:442	(11.17, 39.22, -8.85)
17:42455091	COSM187692	G>D	C:690	(-8.22, -18.25, -13.51)
17:42452071	COSM3518062	P>S	C:936	(-1.76, -1.69, 29.78)
17:42452038	COSM3737384	G>R	C:947	(11.55, -14.09, 37.98)

3FCS.C | ITGA2B.

3FCS.C | ITGA2B

General Structure Information

Variant Set Distributions

Ripley’s K Analysis Plots

Variant Set Comparisons

Mapped Variants

[+] ExAC Missense Variants

[+] ClinVar Missense Variants

[+] COSMIC Missense Variants