General Structure Information
| PDB ID | 2x2u |
| HGNC Gene Label(s) | RET |
| Structure Name | first two cadherin-like domains from human ret |
| Resolution | 2.0Å |
| Reference | AUTH S.KJAER,S.HANRAHAN,N.TOTTY,N.Q.MCDONALDTITL MAMMAL-RESTRICTED ELEMENTS PREDISPOSE HUMAN RET TOTITL 2 FOLDING IMPAIRMENT BY HSCR MUTATIONS.REF NAT.STRUCT.MOL.BIOL. V. 17 726 2010REFN ISSN 1545-9993PMID 20473317DOI 10.1038/NSMB.1808 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 232 |
| Number Of SNVs | 51 |
| Number Of Permutations | 5204 |
| Optimal Distance Threshold | 13.0 |
| K Statistic | 0.124 |
| p-value | 0.21 |
ClinVar
| Number Of Residues | 232 |
| Number Of SNVs | 4 |
| Number Of Permutations | 296 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | 0.0 |
| p-value | 1.0 |
COSMIC
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 51 |
| Number Of ClinVar SNVs | 4 |
| Optimal Distance Threshold | 12.0 |
| K Statistic | -0.106 |
| p-value | 0.914 |
Cosmic vs. ExAC
