General Structure Information
| PDB ID | 1n26 |
| HGNC Gene Label(s) | IL6R |
| Structure Name | crystal structure of the extra-cellular domains of human interleukin-6 receptor alpha chain |
| Resolution | 2.4Å |
| Reference | AUTH J.N.VARGHESE,R.L.MORITZ,M.-Z.LOU,A.VAN DONKELAAR,H.JI,AUTH 2 N.IVANCIC,K.M.BRANSON,N.E.HALL,R.J.SIMPSONTITL STRUCTURE OF THE EXTRACELLULAR DOMAINS OF THE HUMANTITL 2 INTERLEUKIN-6 RECEPTOR ALPHA-CHAIN.REF PROC.NATL.ACAD.SCI.USA V. 99 15959 2002REFN ISSN 0027-8424PMID 12461182DOI 10.1073/PNAS.232432399 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 299 |
| Number Of SNVs | 78 |
| Number Of Permutations | 61192 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.016 |
| p-value | 0.087 |
COSMIC
| Number Of Residues | 299 |
| Number Of SNVs | 8 |
| Number Of Permutations | 4457 |
| Optimal Distance Threshold | 26.0 |
| K Statistic | 0.429 |
| p-value | 0.723 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 78 |
| Number Of COSMIC SNVs | 7 |
| Optimal Distance Threshold | 19.0 |
| K Statistic | 0.084 |
| p-value | 0.638 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
