General Structure Information
| PDB ID | 2x2m |
| HGNC Gene Label(s) | RET |
| Structure Name | crystal structure of phosphorylated ret tyrosine kinase domain with inhibitor |
| Resolution | 2.5Å |
| Reference | AUTH L.MOLOGNI,R.ROSTAGNO,S.BRUSSOLO,P.P.KNOWLES,AUTH 2 S.KJAER,J.MURRAY-RUST,E.ROSSO,A.ZAMBON,L.SCAPOZZA,AUTH 3 N.Q.MCDONALD,V.LUCCHINI,C.GAMBACORTI-PASSERINITITL SYNTHESIS, STRUCTURE-ACTIVITY RELATIONSHIP ANDTITL 2 CRYSTALLOGRAPHIC STUDIES OF 3-SUBSTITUTED INDOLIN-TITL 3 2-ONE RET INHIBITORS.REF BIOORG.MED.CHEM. V. 18 1482 2010REFN ISSN 0968-0896PMID 20117004DOI 10.1016/J.BMC.2010.01.011 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 59 |
| Number Of Permutations | 8017 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.206 |
| p-value | 0.037 |
ClinVar
| Number Of Residues | 274 |
| Number Of SNVs | 17 |
| Number Of Permutations | 2190 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.265 |
| p-value | 0.081 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 13 |
| Number Of Permutations | 8762 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.013 |
| p-value | 0.544 |
Ripley’s K Analysis Plots
ExACClinVarCOSMIC
Variant Set Comparisons
ClinVar vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of ClinVar SNVs | 14 |
| Optimal Distance Threshold | 16.0 |
| K Statistic | 0.153 |
| p-value | 0.049 |
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 25.0 |
| K Statistic | 0.106 |
| p-value | 0.755 |
Pathogenic Proximity Analysis
ClinVar PathProx Analysis
COSMIC PathProx Analysis
