Assessment of Structural Intolerance and Durability
General Structure Information 2qlu ACVR2B crystal structure of activin receptor type ii kinase domain from human 2.0Å AUTH S.HAN,P.LOULAKIS,M.GRIFFOR,Z.XIETITL CRYSTAL STRUCTURE OF ACTIVIN RECEPTOR TYPE IIBTITL 2 KINASE DOMAIN FROM HUMAN AT 2.0 ANGSTROM RESOLUTIONREF PROTEIN SCI. V. 16 2272 2007REFN ISSN 0961-8368PMID 17893364DOI 10.1110/PS.073068407 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2jbm QPRT qprtase structure from human 2.0Å AUTH H.LIU,K.WOZNICA,G.CATTON,A.CRAWFORD,N.BOTTINF,AUTH 2 J.H.NAISMITHTITL STRUCTURAL AND KINETIC CHARACTERIZATION OFTITL 2 QUINOLINATE PHOSPHORIBOSYLTRANSFERASE (HQPRTASE)TITL 3 FROM HOMO SAPIENS.REF J.MOL.BIOL. V. 373 755 2007REFN ISSN 0022-2836PMID 17868694DOI 10.1016/J.JMB.2007.08.043 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 3ogj PRKG1 crystal structure of partial apo (92-227) of cgmp-dependent protein kinase 2.75Å AUTH J.J.KIM,D.E.CASTEEL,G.HUANG,T.H.KWON,R.K.REN,P.ZWART,AUTH 2 J.J.HEADD,N.G.BROWN,D.C.CHOW,T.PALZKILL,C.KIMTITL CO-CRYSTAL STRUCTURES OF PKG IBETA (92-227) WITH CGMP ANDTITL 2 CAMP REVEAL THE MOLECULAR DETAILS OF CYCLIC-NUCLEOTIDETITL 3 BINDINGREF PLOS ONE V. 6 E1841 2011REFN ESSN 1932-6203PMID 21526164DOI 10.1371/JOURNAL.PONE.0018413 Variant Set Distributions Mapped Variants
General Structure Information 3ch4 PMVK the crystal structure of human phosphomavelonate kinase at 1.8 a resolution 1.76Å AUTH Q.CHANG,X.-X.YAN,S.-Y.GU,J.-F.LIU,D.-C.LIANGTITL CRYSTAL STRUCTURE OF HUMAN PHOSPHOMAVELONATETITL 2 KINASE AT 1.8 A RESOLUTIONREF PROTEINS V. 73 254 2008REFN ISSN 0887-3585PMID 18618710DOI 10.1002/PROT.22151 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1y8p PDK3 crystal structure of the pdk3-l2 complex 2.63Å AUTH M.KATO,J.L.CHUANG,S.C.TSO,R.M.WYNN,D.T.CHUANGTITL CRYSTAL STRUCTURE OF PYRUVATE DEHYDROGENASE KINASE 3 BOUNDTITL 2 TO LIPOYL DOMAIN 2 OF HUMAN PYRUVATE DEHYDROGENASE COMPLEX.REF EMBO J. V. 24 1763 2005REFN ISSN 0261-4189PMID 15861126DOI 10.1038/SJ.EMBOJ.7600663 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis […]
General Structure Information 3bhh CAMK2B crystal structure of human calcium/calmodulin-dependent protein kinase iib isoform 1 (camk2b) 2.4Å AUTH P.FILIPPAKOPOULOS,P.RELLOS,F.NIESEN,N.BURGESS,A.BULLOCK,AUTH 2 G.BERRIDGE,A.C.W.PIKE,E.UGOCHUKWU,E.S.PILKA,F.VON DELFT,AUTH 3 C.H.ARROWSMITH,A.M.EDWARDS,J.WEIGELT,S.KNAPPTITL CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENTTITL 2 PROTEIN KINASE IIB ISOFORM 1 (CAMK2B).REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3h8m EPHA7 sam domain of human ephrin type-a receptor 7 (epha7) 2.1Å AUTH J.R.WALKER,L.YERMEKBAYEVA,C.BUTLER-COLE,C.BOUNTRA,AUTH 2 J.WEIGELT,C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL SAM DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7)REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 4fg8 CAMK1 crystal structure of human calcium/calmodulin-dependent protein kinase i 1-315 in complex with atp 2.2Å AUTH M.ZHA,C.ZHONG,Y.OU,L.HAN,J.WANG,J.DINGTITL CRYSTAL STRUCTURES OF HUMAN CAMKIALPHA REVEAL INSIGHTS INTOTITL 2 THE REGULATION MECHANISM OF CAMKI.REF PLOS ONE V. 7 44828 2012REFN ESSN 1932-6203PMID 23028635DOI 10.1371/JOURNAL.PONE.0044828 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2lcx ERBB4 spatial structure of the erbb4 dimeric tm domain -1.0Å AUTH E.V.BOCHAROV,K.S.MINEEV,M.V.GONCHARUK,A.S.ARSENIEVTITL STRUCTURAL AND THERMODYNAMIC INSIGHT INTO THE PROCESS OFTITL 2 WEAK DIMERIZATION OF THE ERBB4 TRANSMEMBRANE DOMAIN BYTITL 3 SOLUTION NMR.REF BIOCHIM.BIOPHYS.ACTA V.1818 2158 2012REFN ISSN 0006-3002PMID 22579757DOI 10.1016/J.BBAMEM.2012.05.001 Variant Set Distributions Mapped Variants
General Structure Information 3orh GAMT human guanidinoacetate n-methyltransferase with sah 1.86Å AUTH H.WU,A.DONG,H.ZENG,P.LOPPNAU,M.SUNDSTROM,C.H.ARROWSMITH,AUTH 2 A.M.EDWARDS,A.BOCHKAREV,A.N.PLOTNIKOVTITL THE CRYSTAL STRUCTURE OF HUMAN GUANIDINOACETATETITL 2 N-METHYLTRANSFERASE WITH SAHREF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants