Assessment of Structural Intolerance and Durability
General Structure Information 1r79 DGKD solution structure of the c1 domain of the human diacylglycerol kinase delta -1.0Å AUTH K.MIYAMOTO,T.TOMIZAWA,S.KOSHIBA,M.INOUE,T.KIGAWA,AUTH 2 S.YOKOYAMATITL SOLUTION STRUCTURE OF THE C1 DOMAIN OF THE HUMANTITL 2 DIACYLGLYCEROL KINASE DELTAREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1wwc NTRK3 nt3 binding domain of human trkc receptor 1.9Å AUTH M.H.ULTSCH,C.WIESMANN,L.C.SIMMONS,J.HENRICH,M.YANG,D.REILLY,AUTH 2 S.H.BASS,A.M.DE VOSTITL CRYSTAL STRUCTURES OF THE NEUROTROPHIN-BINDING DOMAIN OFTITL 2 TRKA, TRKB AND TRKC.REF J.MOL.BIOL. V. 290 149 1999REFN ISSN 0022-2836PMID 10388563DOI 10.1006/JMBI.1999.2816 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2ocp DGUOK crystal structure of human deoxyguanosine kinase 2.8Å AUTH K.JOHANSSON,S.RAMASWAMY,C.LJUNGKRANTZ,W.KNECHT,AUTH 2 J.PISKUR,B.MUNCH-PETERSEN,S.ERIKSSON,H.EKLUNDTITL STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITIES OFTITL 2 CELLULAR DEOXYRIBONUCLEOSIDE KINASES.REF NAT.STRUCT.BIOL. V. 8 616 2001REFN ISSN 1072-8368PMID 11427893DOI 10.1038/89661 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2odt ITPK1 structure of human inositol 1,3,4-trisphosphate 5/6-kinase 2.01Å AUTH R.D.BUSAM,C.ARROWSMITH,H.BERGLUND,R.COLLINS,AUTH 2 A.EDWARDS,U.B.ERICSSON,S.FLODIN,A.FLORES,AUTH 3 M.HAMMARSTROM,S.L.HOLMBERG,I.JOHANSSON,T.KARLBERG,AUTH 4 T.KOTENYOVA,M.MOCHE,M.E.NILSSON,P.NORDLUND,T.NYMAN,AUTH 5 D.OGG,J.SAGEMARK,M.SUNDSTROM,J.UPPENBERG,AUTH 6 S.VAN DEN BERG,J.WEIGELT,C.PERSSON,A.G.THORSELL,AUTH 7 B.M.HALLBERGTITL STRUCTURE OF HUMAN INOSITOL 1,3,4-TRISPHOSPHATETITL 2 5/6-KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3gc9 MAPK11 the structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor 2.05Å AUTH S.B.PATEL,P.M.CAMERON,S.J.OKEEFE,B.FRANTZ-WATTLEY,AUTH 2 J.THOMPSON,E.A.ONEILL,T.TENNIS,L.LIU,J.W.BECKER,G.SCAPINTITL THE THREE-DIMENSIONAL STRUCTURE OF MAP KINASE P38BETA:TITL 2 DIFFERENT FEATURES OF THE ATP-BINDING SITE IN P38BETATITL 3 COMPARED WITH P38ALPHA.REF ACTA CRYSTALLOGR.,SECT.D V. 65 777 2009REFN ISSN 0907-4449PMID 19622861DOI 10.1107/S090744490901600X Variant Set Distributions […]
General Structure Information 3g2f BMPR2 crystal structure of the kinase domain of bone morphogenetic protein receptor type ii (bmpr2) at 2.35 a resolution 2.35Å TITL CRYSTAL STRUCTURE OF THE BMPR2 KINASE DOMAINREF TO BE PUBLISHEDREFN Variant Set Distributions Pathogenic Proximity Analysis Mapped Variants
General Structure Information 4eku PTK2B crystal structure of ferm domain of proline-rich tyrosine kinase 2 3.25Å AUTH B.SAVARIMUTHU,R.LI,Y.WANGTITL CRYSTAL STRUCTURE OF THE FERM DOMAIN OF PROLINE-RICHTITL 2 TYROSINE KINASE 2REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 4iir PRPF4B crystal structure of amppnp-bound human prpf4b kinase domain 2.0Å AUTH Q.GAO,I.MECHIN,N.KOTHARI,Z.GUO,G.DENG,K.HAAS,J.MCMANUS,AUTH 2 D.HOFFMANN,A.WANG,D.WIEDERSCHAIN,J.ROCNIK,W.CZECHTIZKY,AUTH 3 X.CHEN,L.MCLEAN,H.ARLT,D.HARPER,F.LIU,T.MAJID,V.PATEL,AUTH 4 C.LENGAUER,C.GARCIA-ECHEVERRIA,B.ZHANG,H.CHENG,M.DORSCH,AUTH 5 S.M.HUANGTITL EVALUATION OF CANCER DEPENDENCE AND DRUGGABILITY OF PRP4TITL 2 KINASE USING CELLULAR, BIOCHEMICAL, AND STRUCTURALTITL 3 APPROACHES.REF J.BIOL.CHEM. V. 288 30125 2013REFN ISSN 0021-9258PMID 24003220DOI 10.1074/JBC.M113.473348 Variant Set Distributions Ripley’s K […]
General Structure Information 4bl1 MELK crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp 2.6Å AUTH G.CANEVARI,S.RE-DEPAOLINI,U.CUCCHI,B.FORTE,P.CARPINELLI,AUTH 2 J.A.BERTRANDTITL CRYSTAL STRUCTURE OF UNPHOSPHORYLATED MATERNAL EMBRYONICTITL 2 LEUCINE ZIPPER KINASEREF TO BE PUBLISHED Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 1zsg ARHGEF7 beta pix-sh3 complexed with an atypical peptide from alpha- pak -1.0Å AUTH H.R.MOTT,D.NIETLISPACH,K.A.EVETTS,D.OWENTITL STRUCTURAL ANALYSIS OF THE SH3 DOMAIN OF BETA-PIXTITL 2 AND ITS INTERACTION WITH ALPHA-P21 ACTIVATEDTITL 3 KINASE (PAK)REF BIOCHEMISTRY V. 44 10977 2005REFN ISSN 0006-2960PMID 16101281DOI 10.1021/BI050374A Variant Set Distributions Mapped Variants