General Structure Information
| PDB ID | 4iir |
| HGNC Gene Label(s) | PRPF4B |
| Structure Name | crystal structure of amppnp-bound human prpf4b kinase domain |
| Resolution | 2.0Å |
| Reference | AUTH Q.GAO,I.MECHIN,N.KOTHARI,Z.GUO,G.DENG,K.HAAS,J.MCMANUS,AUTH 2 D.HOFFMANN,A.WANG,D.WIEDERSCHAIN,J.ROCNIK,W.CZECHTIZKY,AUTH 3 X.CHEN,L.MCLEAN,H.ARLT,D.HARPER,F.LIU,T.MAJID,V.PATEL,AUTH 4 C.LENGAUER,C.GARCIA-ECHEVERRIA,B.ZHANG,H.CHENG,M.DORSCH,AUTH 5 S.M.HUANGTITL EVALUATION OF CANCER DEPENDENCE AND DRUGGABILITY OF PRP4TITL 2 KINASE USING CELLULAR, BIOCHEMICAL, AND STRUCTURALTITL 3 APPROACHES.REF J.BIOL.CHEM. V. 288 30125 2013REFN ISSN 0021-9258PMID 24003220DOI 10.1074/JBC.M113.473348 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 325 |
| Number Of SNVs | 16 |
| Number Of Permutations | 3219 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.0 |
| p-value | 0.666 |
COSMIC
| Number Of Residues | 325 |
| Number Of SNVs | 5 |
| Number Of Permutations | 1190 |
| Optimal Distance Threshold | 21.0 |
| K Statistic | 0.2 |
| p-value | 0.997 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 16 |
| Number Of COSMIC SNVs | 5 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | -0.075 |
| p-value | 0.634 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
