General Structure Information
| PDB ID | 4bl1 |
| HGNC Gene Label(s) | MELK |
| Structure Name | crystal structure of unphosphorylated maternal embryonic leucine zipper kinase (melk) in complex with amp-pnp |
| Resolution | 2.6Å |
| Reference | AUTH G.CANEVARI,S.RE-DEPAOLINI,U.CUCCHI,B.FORTE,P.CARPINELLI,AUTH 2 J.A.BERTRANDTITL CRYSTAL STRUCTURE OF UNPHOSPHORYLATED MATERNAL EMBRYONICTITL 2 LEUCINE ZIPPER KINASEREF TO BE PUBLISHED |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 312 |
| Number Of SNVs | 84 |
| Number Of Permutations | 15952 |
| Optimal Distance Threshold | 9.0 |
| K Statistic | 0.036 |
| p-value | 0.737 |
COSMIC
| Number Of Residues | 312 |
| Number Of SNVs | 8 |
| Number Of Permutations | 1856 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.071 |
| p-value | 0.312 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 84 |
| Number Of COSMIC SNVs | 6 |
| Optimal Distance Threshold | 4.0 |
| K Statistic | 0.066 |
| p-value | 0.988 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
