General Structure Information
| PDB ID | 3gc9 |
| HGNC Gene Label(s) | MAPK11 |
| Structure Name | the structure of p38beta c119s, c162s in complex with a dihydroquinazolinone inhibitor |
| Resolution | 2.05Å |
| Reference | AUTH S.B.PATEL,P.M.CAMERON,S.J.OKEEFE,B.FRANTZ-WATTLEY,AUTH 2 J.THOMPSON,E.A.ONEILL,T.TENNIS,L.LIU,J.W.BECKER,G.SCAPINTITL THE THREE-DIMENSIONAL STRUCTURE OF MAP KINASE P38BETA:TITL 2 DIFFERENT FEATURES OF THE ATP-BINDING SITE IN P38BETATITL 3 COMPARED WITH P38ALPHA.REF ACTA CRYSTALLOGR.,SECT.D V. 65 777 2009REFN ISSN 0907-4449PMID 19622861DOI 10.1107/S090744490901600X |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 335 |
| Number Of SNVs | 62 |
| Number Of Permutations | 31355 |
| Optimal Distance Threshold | 18.0 |
| K Statistic | 0.179 |
| p-value | 0.027 |
COSMIC
| Number Of Residues | 335 |
| Number Of SNVs | 4 |
| Number Of Permutations | 258 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.167 |
| p-value | 0.314 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 62 |
| Number Of COSMIC SNVs | 4 |
| Optimal Distance Threshold | 7.0 |
| K Statistic | 0.142 |
| p-value | 0.124 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
