Assessment of Structural Intolerance and Durability
General Structure Information 2fbv WRN wrn exonuclease, mn complex 2.4Å AUTH J.J.PERRY,S.M.YANNONE,L.G.HOLDEN,C.HITOMI,AUTH 2 A.ASAITHAMBY,S.HAN,P.K.COOPER,D.J.CHEN,J.A.TAINERTITL WRN EXONUCLEASE STRUCTURE AND MOLECULAR MECHANISMTITL 2 IMPLY AN EDITING ROLE IN DNA END PROCESSING.REF NAT.STRUCT.MOL.BIOL. V. 13 414 2006REFN ISSN 1545-9993PMID 16622405DOI 10.1038/NSMB1088 Variant Set Distributions Mapped Variants
General Structure Information 4iz5 PEA15 structure of the complex between erk2 phosphomimetic mutant and pea-15 3.19Å AUTH P.D.MACE,Y.WALLEZ,M.F.EGGER,M.K.DOBACZEWSKA,H.ROBINSON,AUTH 2 E.B.PASQUALE,S.J.RIEDLTITL STRUCTURE OF ERK2 BOUND TO PEA-15 REVEALS A MECHANISM FORTITL 2 RAPID RELEASE OF ACTIVATED MAPK.REF NAT COMMUN V. 4 1681 2013REFN ESSN 2041-1723PMID 23575685DOI 10.1038/NCOMMS2687 Variant Set Distributions Mapped Variants
General Structure Information 2ux0 CAMK2G structure of the oligomerisation domain of calcium- calmodulin dependent protein kinase ii gamma 2.46Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 2vn9 CAMK2D crystal structure of human calcium calmodulin dependent protein kinase ii delta isoform 1, camkd 2.3Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 2rei EPHA7 kinase domain of human ephrin type-a receptor 7 (epha7) 1.6Å AUTH J.R.WALKER,D.CUERRIER,C.BUTLER-COLE,J.WEIGELT,AUTH 2 C.H.ARROWSMITH,A.M.EDWARDS,A.BOCHKAREV,AUTH 3 S.DHE-PAGANONTITL KINASE DOMAIN OF HUMAN EPHRIN TYPE-A RECEPTOR 7TITL 2 (EPHA7).REF TO BE PUBLISHEDREFN Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2azt GNMT crystal structure of h176n mutant of human glycine n-methyltransferase 2.7Å AUTH Z.LUKA,S.PAKHOMOVA,Y.LUKA,M.E.NEWCOMER,C.WAGNERTITL DESTABILIZATION OF HUMAN GLYCINE N-METHYLTRANSFERASE BYTITL 2 H176N MUTATION.REF PROTEIN SCI. V. 16 1957 2007REFN ISSN 0961-8368PMID 17660255DOI 10.1110/PS.072921507 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Pathogenic Proximity Analysis Mapped Variants
General Structure Information 2v7o CAMK2G crystal structure of human calcium-calmodulin-dependent protein kinase ii gamma 2.25Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons […]
General Structure Information 2kgt PTK6 solution structure of sh3 domain of ptk6 -1.0Å AUTH W.LEE,S.KOTITL THE SOLUTION STRUCTURE OF SH3 DOMAIN OF PTK6REF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 3o0z ROCK1 crystal structure of a coiled-coil domain from human rock i 2.33Å AUTH D.TU,Y.LI,H.K.SONG,A.V.TOMS,C.J.GOULD,S.B.FICARRO,J.A.MARTO,AUTH 2 B.L.GOODE,M.J.ECKTITL CRYSTAL STRUCTURE OF A COILED-COIL DOMAIN FROM HUMAN ROCK I.REF PLOS ONE V. 6 E1808 2011REFN ESSN 1932-6203PMID 21445309DOI 10.1371/JOURNAL.PONE.0018080 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3o0z ROCK1 crystal structure of a coiled-coil domain from human rock i 2.33Å AUTH D.TU,Y.LI,H.K.SONG,A.V.TOMS,C.J.GOULD,S.B.FICARRO,J.A.MARTO,AUTH 2 B.L.GOODE,M.J.ECKTITL CRYSTAL STRUCTURE OF A COILED-COIL DOMAIN FROM HUMAN ROCK I.REF PLOS ONE V. 6 E1808 2011REFN ESSN 1932-6203PMID 21445309DOI 10.1371/JOURNAL.PONE.0018080 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants