Assessment of Structural Intolerance and Durability
General Structure Information 3bbt ERBB4 crystal structure of the erbb4 kinase in complex with lapatinib 2.8Å AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 Variant Set Distributions Ripley’s K Analysis Plots Variant Set Comparisons Mapped Variants
General Structure Information 3e0j POLD3 x-ray structure of the complex of regulatory subunits of human dna polymerase delta 3.0Å AUTH A.G.BARANOVSKIY,N.D.BABAYEVA,V.G.LISTON,AUTH 2 I.B.ROGOZIN,E.V.KOONIN,Y.I.PAVLOV,D.G.VASSYLYEV,AUTH 3 T.H.TAHIROVTITL X-RAY STRUCTURE OF THE COMPLEX OF REGULATORYTITL 2 SUBUNITS OF HUMAN DNA POLYMERASE DELTA.REF CELL CYCLE V. 7 3026 2008REFN ISSN 1538-4101PMID 18818516 Variant Set Distributions Mapped Variants
General Structure Information 2q8h PDK1 structure of pyruvate dehydrogenase kinase isoform 1 in complex with dichloroacetate (dca) 2.0Å AUTH M.KATO,J.LI,J.L.CHUANG,D.T.CHUANGTITL DISTINCT STRUCTURAL MECHANISMS FOR INHIBITION OF PYRUVATETITL 2 DEHYDROGENASE KINASE ISOFORMS BY AZD7545, DICHLOROACETATE,TITL 3 AND RADICICOL.REF STRUCTURE V. 15 992 2007REFN ISSN 0969-2126PMID 17683942DOI 10.1016/J.STR.2007.07.001 Variant Set Distributions Ripley’s K Analysis Plots Variant Set […]
General Structure Information 2hlq BMPR2 crystal structure of the extracellular domain of the type ii bmp receptor 1.45Å AUTH P.D.MACE,J.F.CUTFIELD,S.M.CUTFIELDTITL HIGH RESOLUTION STRUCTURES OF THE BONETITL 2 MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN TWOTITL 3 CRYSTAL FORMS: IMPLICATIONS FOR LIGAND BINDINGREF BIOCHEM.BIOPHYS.RES.COMMUN. V. 351 831 2006REFN ISSN 0006-291XPMID 17094948DOI 10.1016/J.BBRC.2006.10.109 Variant Set Distributions Mapped Variants
General Structure Information 2w2c CAMK2D structure of the tetradecameric oligomerisation domain of calcium-calmodulin dependent protein kinase ii delta 2.7Å AUTH P.RELLOS,A.C.W.PIKE,F.H.NIESEN,E.SALAH,W.H.LEE,AUTH 2 F.VON DELFT,S.KNAPPTITL STRUCTURE OF THE CAMKIIDELTA/CALMODULIN COMPLEXTITL 2 REVEALS THE MOLECULAR MECHANISM OF CAMKII KINASETITL 3 ACTIVATION.REF PLOS BIOL. V. 8 426 2010REFN ISSN 1544-9173PMID 20668654DOI 10.1371/JOURNAL.PBIO.1000426 Variant Set Distributions Mapped Variants
General Structure Information 3fzt PTK2B crystal structure of pyk2 complexed with pf-4618433 1.95Å AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 Variant Set Distributions Ripley’s K Analysis Plots Variant […]
General Structure Information 2z7q RPS6KA1 crystal structure of the n-terminal kinase domain of human rsk-1 bound to amp-pcp 2.0Å AUTH M.IKUTA,M.KORNIENKO,N.BYRNE,J.C.REID,S.MIZUARAI,H.KOTANI,AUTH 2 S.K.MUNSHITITL CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN OF HUMANTITL 2 RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS FOR THETITL 3 DESIGN OF RSK1 SPECIFIC INHIBITORS.REF PROTEIN SCI. V. 16 2626 2007REFN ISSN […]
General Structure Information 2wnt RPS6KA1 crystal structure of the human ribosomal protein s6 kinase 2.4Å AUTH J.R.C.MUNIZ,J.M.ELKINS,J.WANG,E.UGOCHUKWU,E.SALAH,AUTH 2 O.KING,S.PICAUD,F.VON DELFT,C.BOUNTRA,AUTH 3 C.H.ARROWSMITH,J.WEIGELT,A.EDWARDS,S.KNAPPTITL CRYSTAL STRUCTURE OF THE HUMAN RIBOSOMAL PROTEINTITL 2 S6 KINASEREF TO BE PUBLISHEDREFN Variant Set Distributions Mapped Variants
General Structure Information 1bwn BTK ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 2.1Å AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 Variant Set Distributions Ripley’s K […]
General Structure Information 1bwn BTK ph domain and btk motif from brutons tyrosine kinase mutant e41k in complex with ins(1,3,4,5)p4 2.1Å AUTH E.BARALDI,K.D.CARUGO,M.HYVONEN,P.L.SURDO,A.M.RILEY,AUTH 2 B.V.POTTER,R.OBRIEN,J.E.LADBURY,M.SARASTETITL STRUCTURE OF THE PH DOMAIN FROM BRUTONS TYROSINE KINASE INTITL 2 COMPLEX WITH INOSITOL 1,3,4,5-TETRAKISPHOSPHATE.REF STRUCTURE FOLD.DES. V. 7 449 1999REFN ISSN 0969-2126PMID 10196129DOI 10.1016/S0969-2126(99)80057-4 Variant Set Distributions Ripley’s K […]