General Structure Information
| PDB ID | 3fzt |
| HGNC Gene Label(s) | PTK2B |
| Structure Name | crystal structure of pyk2 complexed with pf-4618433 |
| Resolution | 1.95Å |
| Reference | AUTH S.HAN,A.MISTRY,J.S.CHANG,D.CUNNINGHAM,M.GRIFFOR,AUTH 2 P.C.BONNETTE,H.WANG,B.A.CHRUNYK,G.E.ASPNES,AUTH 3 D.P.WALKER,A.D.BROSIUS,L.BUCKBINDERTITL STRUCTURAL CHARACTERIZATION OF PROLINE-RICHTITL 2 TYROSINE KINASE 2 (PYK2) REVEALS A UNIQUE (DFG-OUT)TITL 3 CONFORMATION AND ENABLES INHIBITOR DESIGN.REF J.BIOL.CHEM. V. 284 13193 2009REFN ISSN 0021-9258PMID 19244237DOI 10.1074/JBC.M809038200 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 259 |
| Number Of SNVs | 59 |
| Number Of Permutations | 29460 |
| Optimal Distance Threshold | 15.0 |
| K Statistic | 0.162 |
| p-value | 0.298 |
COSMIC
| Number Of Residues | 259 |
| Number Of SNVs | 10 |
| Number Of Permutations | 2001 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.133 |
| p-value | 0.876 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 59 |
| Number Of COSMIC SNVs | 10 |
| Optimal Distance Threshold | 11.0 |
| K Statistic | 0.053 |
| p-value | 0.943 |
Pathogenic Proximity Analysis
COSMIC PathProx Analysis
