General Structure Information
| PDB ID | 3bbt |
| HGNC Gene Label(s) | ERBB4 |
| Structure Name | crystal structure of the erbb4 kinase in complex with lapatinib |
| Resolution | 2.8Å |
| Reference | AUTH C.QIU,M.K.TARRANT,S.H.CHOI,A.SATHYAMURTHY,R.BOSE,S.BANJADE,AUTH 2 A.PAL,W.G.BORNMANN,M.A.LEMMON,P.A.COLE,D.J.LEAHYTITL MECHANISM OF ACTIVATION AND INHIBITION OF THE HER4/ERBB4TITL 2 KINASE.REF STRUCTURE V. 16 460 2008REFN ISSN 0969-2126PMID 18334220DOI 10.1016/J.STR.2007.12.016 |
Variant Set Distributions
ExAC Variants
| Number Of Residues | 274 |
| Number Of SNVs | 53 |
| Number Of Permutations | 9471 |
| Optimal Distance Threshold | 8.0 |
| K Statistic | 0.029 |
| p-value | 0.87 |
COSMIC
| Number Of Residues | 274 |
| Number Of SNVs | 14 |
| Number Of Permutations | 4123 |
| Optimal Distance Threshold | 20.0 |
| K Statistic | 0.231 |
| p-value | 0.288 |
Ripley’s K Analysis Plots
ExACCOSMIC
Variant Set Comparisons
Cosmic vs. ExAC
| Number Of ExAC SNVs | 53 |
| Number Of COSMIC SNVs | 14 |
| Optimal Distance Threshold | 29.0 |
| K Statistic | -0.202 |
| p-value | 0.094 |